Faculty Appointments
Research Associate Professor of Pharmacology
Education
Ph.D., Cancer Biology, Vanderbilt University, Nashville, TennesseeB.S., Biology, East Tennessee State University, Johnson City, Tennessee
Publications
Linkous A, Balamatsias D, Snuderl M, Edwards L, Miyaguchi K, Milner T, Reich B, Cohen-Gould L, Storaska A, Nakayama Y, Schenkein E, Singhania R, Cirigliano S, Magdeldin T, Lin Y, Nanjangud G, Chadalavada K, Pisapia D, Liston C, Fine HA. Modeling Patient-Derived Glioblastoma with Cerebral Organoids. Cell Rep. 2019 Mar 3/19/2019; 26(12): 3203-3211.e5. PMID: 30893594, PMCID: PMC6625753, PII: S2211-1247(19)30242-6, DOI: 10.1016/j.celrep.2019.02.063, ISSN: 2211-1247.
Baysan M, Woolard K, Cam MC, Zhang W, Song H, Kotliarova S, Balamatsias D, Linkous A, Ahn S, Walling J, Belova GI, Fine HA. Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence. Int. J. Cancer [print-electronic]. 2017 Nov 11/15/2017; 141(10): 2002-13. PMID: 28710771, DOI: 10.1002/ijc.30887, ISSN: 1097-0215.
Riddick G, Kotliarova S, Rodriguez V, Kim HS, Linkous A, Storaska AJ, Ahn S, Walling J, Belova G, Fine HA. A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity. Sci Rep. 2017 Mar 3/3/2017; 7: 43605. PMID: 28256619, PMCID: PMC5335262, PII: srep43605, DOI: 10.1038/srep43605, ISSN: 2045-2322.
Bhave SR, Dadey DY, Karvas RM, Ferraro DJ, Kotipatruni RP, Jaboin JJ, Hallahan AN, Dewees TA, Linkous AG, Hallahan DE, Thotala D. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013; 3: 236. PMID: 24062988, PMCID: PMC3775313, DOI: 10.3389/fonc.2013.00236, ISSN: 2234-943X.
Linkous AG, Yazlovitskaya EM. Novel radiosensitizing anticancer therapeutics. Anticancer Res. 2012 Jul; 32(7): 2487-99. PMID: 22753705, PII: 32/7/2487, ISSN: 1791-7530.
Linkous AG, Yazlovitskaya EM. Novel therapeutic approaches for targeting tumor angiogenesis. Anticancer Res. 2012 Jan; 32(1): 1-12. PMID: 22213282, PII: 32/1/1, ISSN: 1791-7530.
Linkous AG, Yazlovitskaya EM. Angiogenesis in glioblastoma multiforme: navigating the maze. Anticancer Agents Med Chem. 2011 Oct; 11(8): 712-8. PMID: 21707499, PII: BSP/ACAMC/E-Pub/ 00199, ISSN: 1875-5992.
Schulte RR, Linkous AG, Hallahan DE, Yazlovitskaya EM. Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer. Cancer Lett. 2011 May 5/28/2011; 304(2): 137-43. PMID: 21397389, PMCID: PMC3075208, PII: S0304-3835(11)00088-7, DOI: 10.1016/j.canlet.2011.02.015, ISSN: 1872-7980.
Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE. Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS ONE [print-electronic]. 2011; 6(7): e22182. PMID: 21799791, PMCID: PMC3140496, PII: 10-PONE-RA-19483, DOI: 10.1371/journal.pone.0022182, ISSN: 1932-6203.
Linkous A, Yazlovitskaya E. Cytosolic phospholipase A2 as a mediator of disease pathogenesis. Cell. Microbiol. 2010 Oct; 12(10): 1369-77. PMID: 20642808, PII: CMI1505, DOI: 10.1111/j.1462-5822.2010.01505.x, ISSN: 1462-5822.
Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J. Natl. Cancer Inst [print-electronic]. 2010 Sep 9/22/2010; 102(18): 1398-412. PMID: 20729478, PMCID: PMC2943523, PII: djq290, DOI: 10.1093/jnci/djq290, ISSN: 1460-2105.
Linkous A, Geng L, Lyshchik A, Hallahan DE, Yazlovitskaya EM. Cytosolic phospholipase A2: targeting cancer through the tumor vasculature. Clin. Cancer Res [print-electronic]. 2009 Mar 3/1/2009; 15(5): 1635-44. PMID: 19240173, PMCID: PMC2874582, PII: 1078-0432.CCR-08-1905, DOI: 10.1158/1078-0432.CCR-08-1905, ISSN: 1078-0432.
Yazlovitskaya EM, Linkous AG, Thotala DK, Cuneo KC, Hallahan DE. Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium. Cell Death Differ [print-electronic]. 2008 Oct; 15(10): 1641-53. PMID: 18566601, PII: cdd200893, DOI: 10.1038/cdd.2008.93, ISSN: 1350-9047.
Baysan M, Woolard K, Cam MC, Zhang W, Song H, Kotliarova S, Balamatsias D, Linkous A, Ahn S, Walling J, Belova GI, Fine HA. Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence. Int. J. Cancer [print-electronic]. 2017 Nov 11/15/2017; 141(10): 2002-13. PMID: 28710771, DOI: 10.1002/ijc.30887, ISSN: 1097-0215.
Riddick G, Kotliarova S, Rodriguez V, Kim HS, Linkous A, Storaska AJ, Ahn S, Walling J, Belova G, Fine HA. A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity. Sci Rep. 2017 Mar 3/3/2017; 7: 43605. PMID: 28256619, PMCID: PMC5335262, PII: srep43605, DOI: 10.1038/srep43605, ISSN: 2045-2322.
Bhave SR, Dadey DY, Karvas RM, Ferraro DJ, Kotipatruni RP, Jaboin JJ, Hallahan AN, Dewees TA, Linkous AG, Hallahan DE, Thotala D. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013; 3: 236. PMID: 24062988, PMCID: PMC3775313, DOI: 10.3389/fonc.2013.00236, ISSN: 2234-943X.
Linkous AG, Yazlovitskaya EM. Novel radiosensitizing anticancer therapeutics. Anticancer Res. 2012 Jul; 32(7): 2487-99. PMID: 22753705, PII: 32/7/2487, ISSN: 1791-7530.
Linkous AG, Yazlovitskaya EM. Novel therapeutic approaches for targeting tumor angiogenesis. Anticancer Res. 2012 Jan; 32(1): 1-12. PMID: 22213282, PII: 32/1/1, ISSN: 1791-7530.
Linkous AG, Yazlovitskaya EM. Angiogenesis in glioblastoma multiforme: navigating the maze. Anticancer Agents Med Chem. 2011 Oct; 11(8): 712-8. PMID: 21707499, PII: BSP/ACAMC/E-Pub/ 00199, ISSN: 1875-5992.
Schulte RR, Linkous AG, Hallahan DE, Yazlovitskaya EM. Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer. Cancer Lett. 2011 May 5/28/2011; 304(2): 137-43. PMID: 21397389, PMCID: PMC3075208, PII: S0304-3835(11)00088-7, DOI: 10.1016/j.canlet.2011.02.015, ISSN: 1872-7980.
Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE. Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS ONE [print-electronic]. 2011; 6(7): e22182. PMID: 21799791, PMCID: PMC3140496, PII: 10-PONE-RA-19483, DOI: 10.1371/journal.pone.0022182, ISSN: 1932-6203.
Linkous A, Yazlovitskaya E. Cytosolic phospholipase A2 as a mediator of disease pathogenesis. Cell. Microbiol. 2010 Oct; 12(10): 1369-77. PMID: 20642808, PII: CMI1505, DOI: 10.1111/j.1462-5822.2010.01505.x, ISSN: 1462-5822.
Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J. Natl. Cancer Inst [print-electronic]. 2010 Sep 9/22/2010; 102(18): 1398-412. PMID: 20729478, PMCID: PMC2943523, PII: djq290, DOI: 10.1093/jnci/djq290, ISSN: 1460-2105.
Linkous A, Geng L, Lyshchik A, Hallahan DE, Yazlovitskaya EM. Cytosolic phospholipase A2: targeting cancer through the tumor vasculature. Clin. Cancer Res [print-electronic]. 2009 Mar 3/1/2009; 15(5): 1635-44. PMID: 19240173, PMCID: PMC2874582, PII: 1078-0432.CCR-08-1905, DOI: 10.1158/1078-0432.CCR-08-1905, ISSN: 1078-0432.
Yazlovitskaya EM, Linkous AG, Thotala DK, Cuneo KC, Hallahan DE. Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium. Cell Death Differ [print-electronic]. 2008 Oct; 15(10): 1641-53. PMID: 18566601, PII: cdd200893, DOI: 10.1038/cdd.2008.93, ISSN: 1350-9047.