James W. Antoon, M.D., Ph.D.

Assistant Professor

james.w.antoon@vanderbilt.edu
Faculty Appointments
Assistant Professor of Pediatrics
Education
M.D., Tulane University, New Orleans, LouisianaPh.D., Biomedical Sciences, Tulane University, New Orleans, LouisianaM.S., Tulane University, New Orleans, LouisianaB.A., Davidson College, Davidson, North Carolina
Research Description
Dr. Antoon is an NIH funded clinical and health services researcher with a program focused on pharmacoepidemiology and medication safety in the pediatric population. As a physician-scientist, Dr. Antoon designs and conducts pragmatic clinical trials and population-based observational studies, with a focus on the treatment of respiratory viruses (e.g. influenza, COVID-19, RSV) in children. He evaluates the relationship between serious adverse events and medication exposures, as well as determining the role of drug-drug interactions and underlying infections in the development of serious adverse events in children. Dr. Antoon’s recent studies have investigated medication-related neurologic and psychiatric adverse events, severe cutaneous adverse reactions (e.g, Stevens Johnson Syndrome), and anaphylactic reactions, among others. Dr. Antoon is currently the principal investigator of a randomized clinical trial evaluating penicillin allergy risk stratification and delabeling of low risk patients in the hospital setting.

Dr. Antoon has authored more than 100 peer-reviewed articles and book chapters in the fields of pediatrics, pharmacology, and drug safety. He is a member of the Society for Pediatric Research, the International Society for Influenza and Other Respiratory Virus Diseases, and the International Society for Pharmacoepidemiology. Dr. Antoon was a 2021 recipient of the Young Investigator Award from the Academic Pediatric Association.
Research Keywords
Pediatric pharmacoepidemiology, drug safety, adverse drug events, influenza, RSV, COVID-19
Publications
Wolf RM, Hall M, Williams DJ, Carroll AR, Antoon JW, Brown CM, Herndon A, Kreth H, Lind C, Gastineau KAB, Spencer K, Ngo ML, Hart S, White L, Johnson DP. Pharmacologic restraint use for children experiencing mental health crises in pediatric hospitals. J Hosp Med [print-electronic]. 2022 Nov 11/22/2022; PMID: 36415909, DOI: 10.1002/jhm.13009, ISSN: 1553-5606.

Antoon JW, Hall M, Howard LM, Herndon A, Freundlich KL, Grijalva CG, Williams DJ. COVID-19 and Acute Neurologic Complications in Children. Pediatrics [print-electronic]. 2022 Aug 8/11/2022; PMID: 35949041, PII: 188743, DOI: 10.1542/peds.2022-058167, ISSN: 1098-4275.

Antoon JW, Hall M, Feinstein JA, Kyler KE, Shah SS, Girdwood ST, Goldman JL, Grijalva CG, Williams DJ. Guideline Concordant Antiviral Treatment in Children at High-risk for Influenza Complications. Clin Infect Dis [print-electronic]. 2022 Jul 7/22/2022; PMID: 35867691, PII: 6648551, DOI: 10.1093/cid/ciac606, ISSN: 1537-6591.

Burns JE, Thurm C, Antoon JW, Grijalva CG, Hall M, Hersh AL, Hester GZ, Korn E, Reyes MA, Shah SS, Totapally BR, Teufel Ii RJ. Medications and Adherence to Treatment Guidelines Among Children Hospitalized With Acute COVID-19. Pediatrics [print-electronic]. 2022 Jun 6/15/2022; PMID: 35701866, PII: 188276, DOI: 10.1542/peds.2022-056606, ISSN: 1098-4275.

Antoon JW, Grijalva CG, Grisso AG, Stone CA, Johnson J, Stassun J, Norton AE, Kripalani S, Williams DJ. Feasibility of a Centralized, Pharmacy-Led Penicillin Allergy Delabeling Program. Hosp Pediatr [print-electronic]. 2022 Jun 6/9/2022; PMID: 35678128, PII: 188258, DOI: 10.1542/hpeds.2021-006369, ISSN: 2154-1671.

Antoon JW, Feinstein JA, Grijalva CG, Zhu Y, Dickinson E, Stassun JC, Johnson JA, Sekmen M, Tanguturi YC, Gay JC, Williams DJ. Identifying Acute Neuropsychiatric Events in Children and Adolescents. Hosp Pediatr [print-electronic]. 2022 Apr 4/8/2022; PMID: 35393609, PII: 186713, DOI: 10.1542/hpeds.2021-006329, ISSN: 2154-1671.

Arnold DH, Gong W, Antoon JW, Bacharier LB, Stewart TG, Johnson DP, Akers WS, Hartert TV. Prospective Observational Study of Clinical Outcomes After Intravenous Magnesium for Moderate and Severe Acute Asthma Exacerbations in Children. J Allergy Clin Immunol Pract [print-electronic]. 2021 Dec 12/13/2021; PMID: 34915226, PII: S2213-2198(21)01366-0, DOI: 10.1016/j.jaip.2021.11.028, ISSN: 2213-2201.

Antoon JW, Grijalva CG, Thurm C, Richardson T, Spaulding AB, Teufel RJ, Reyes MA, Shah SS, Burns JE, Kenyon CC, Hersh AL, Williams DJ. Factors Associated With COVID-19 Disease Severity in US Children and Adolescents. J Hosp Med. 2021 Oct; 16(10): 603-10. PMID: 34613896, PII: jhm.3689, DOI: 10.12788/jhm.3689, ISSN: 1553-5606.

Carroll AR, Hall M, Brown CM, Johnson DP, Antoon JW, Kreth H, Ngo ML, Browning W, Neeley M, Herndon A, Chokshi SB, Plemmons G, Johnson J, Hart SR, Williams DJ. Association of Race/Ethnicity and Social Determinants with Rehospitalization for Mental Health Conditions at Acute Care Children's Hospitals. J Pediatr [print-electronic]. 2021 Aug 8/31/2021; PMID: 34478747, PII: S0022-3476(21)00863-5, DOI: 10.1016/j.jpeds.2021.08.078, ISSN: 1097-6833.

Antoon JW, Hall M, Mittal V, Parikh K, Morse RB, Teufel RJ, Hogan AH, Shah SS, Kenyon CC. Intravenous Magnesium and Hospital Outcomes in Children Hospitalized With Asthma. Hosp Pediatr [print-electronic]. 2021 Jul 7/1/2021; PMID: 34210764, PII: hpeds.2020-004770, DOI: 10.1542/hpeds.2020-004770, ISSN: 2154-1671.

Antoon JW, Hall M, Herndon A, Johnson DP, Brown CM, Browning WL, Florin TA, Howard LM, Grijalva CG, Williams DJ. Prevalence, Risk Factors, and Outcomes of Influenza-Associated Neurologic Complications in Children. J Pediatr [print-electronic]. 2021 Jun 6/30/2021; PMID: 34216629, PII: S0022-3476(21)00657-0, DOI: 10.1016/j.jpeds.2021.06.075, ISSN: 1097-6833.

Antoon JW, Grisso AG, Stone CA. Breaking the Mold: Safely Delabeling Penicillin Allergies in Hospitalized Children. Hosp Pediatr [print-electronic]. 2021 Apr 4/13/2021; PMID: 33849961, PII: hpeds.2020-005280, DOI: 10.1542/hpeds.2020-005280, ISSN: 2154-1671.

Antoon JW, Williams DJ, Thurm C, Bendel-Stenzel M, Spaulding AB, Teufel RJ, Reyes MA, Shah SS, Kenyon CC, Hersh AL, Florin TA, Grijalva CG. The COVID-19 Pandemic and Changes in Healthcare Utilization for Pediatric Respiratory and Nonrespiratory Illnesses in the United States. J Hosp Med [print-electronic]. 2021 Mar 3/8/2021; PMID: 33734976, PII: jhm.3608, DOI: 10.12788/jhm.3608, ISSN: 1553-5606.

Thomson J, Hall M, Nelson K, Flores JC, Garrity B, DeCourcey DD, Agrawal R, Goodman DM, Feinstein JA, Coller RJ, Cohen E, Kuo DZ, Antoon JW, Houtrow AJ, Bastianelli L, Berry JG. Timing of Co-occurring Chronic Conditions in Children With Neurologic Impairment. Pediatrics [print-electronic]. 2021 Feb; 147(2): PMID: 33414236, PMCID: PMC7849195, PII: peds.2020-009217, DOI: 10.1542/peds.2020-009217, ISSN: 1098-4275.

Antoon JW, Hall M, Herndon A, Carroll A, Ngo ML, Freundlich KL, Stassun JC, Frost P, Johnson DP, Chokshi SB, Brown CM, Browning WL, Feinstein JA, Grijalva CG, Williams DJ. Prevalence of Clinically Significant Drug-Drug Interactions Across US Children's Hospitals. Pediatrics [print-electronic]. 2020 Nov; 146(5): PMID: 33037121, PMCID: PMC7786820, PII: peds.2020-0858, DOI: 10.1542/peds.2020-0858, ISSN: 1098-4275.

Mier M, Antoon JW, Sefcovic S, Awatramani S, Kreppel A, Smith SB. Affecting Length of Stay in Well-appearing Febrile Infants. Pediatr Qual Saf. 2020 Nov; 5(6): e359. PMID: 33575521, PMCID: PMC7870218, DOI: 10.1097/pq9.0000000000000359, ISSN: 2472-0054.

Markham JL, Thurm CW, Hall M, Shah SS, Quinonez R, Tchou MJ, Antoon JW, Genies MC, Parlar-Chun R, Johnson DP, Shah SP, Ittel M, Brady PW. Variation in Early Inflammatory Marker Testing for Infection-Related Hospitalizations in Children. Hosp Pediatr [print-electronic]. 2020 Oct; 10(10): 851-8. PMID: 32948631, PII: hpeds.2020-0114, DOI: 10.1542/hpeds.2020-0114, ISSN: 2154-1671.

Mittal V, Hall M, Antoon J, Gold J, Kenyon C, Parikh K, Morse R, Quinonez R, Teufel RJ, Shah SS. Trends in Intravenous Magnesium Use and Outcomes for Status Asthmaticus in Children's Hospitals from 2010 to 2017. J Hosp Med [print-electronic]. 2020 Jul 7/1/2020; 15(7): 403-6. PMID: 32584247, PMCID: PMC7402601, PII: jhm.3405, DOI: 10.12788/jhm.3405, ISSN: 1553-5606.

Vyles D, Antoon JW, Norton A, Stone CA, Trubiano J, Radowicz A, Phillips EJ. Children with reported penicillin allergy: Public health impact and safety of delabeling. Ann Allergy Asthma Immunol [print-electronic]. 2020 Jun; 124(6): 558-65. PMID: 32224207, PMCID: PMC7255916, PII: S1081-1206(20)30156-3, DOI: 10.1016/j.anai.2020.03.012, ISSN: 1534-4436.

Antoon JW, Goldman JL, Lee BR. Severe cutaneous adverse reactions: comparing outcomes in children with and without complex chronic conditions. J Allergy Clin Immunol Pract [print-electronic]. 2020 Feb; 8(2): 790-792.e3. PMID: 31421280, PII: S2213-2198(19)30709-3, DOI: 10.1016/j.jaip.2019.07.043, ISSN: 2213-2201.

Tchou MJ, Hall M, Shah SS, Johnson DP, Schroeder AR, Antoon JW, Genies MC, Quinonez R, Miller CW, Shah SP, Brady PW, . Patterns of Electrolyte Testing at Children's Hospitals for Common Inpatient Diagnoses. Pediatrics [print-electronic]. 2019 Jul; 144(1): PMID: 31171587, PMCID: PMC6615522, PII: peds.2018-1644, DOI: 10.1542/peds.2018-1644, ISSN: 1098-4275.