Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., Biochemistry, Vanderbilt University, Nashville, TennesseeB.S., Biochemistry & Biology, Carson-Newman College, Jefferson City, Tennessee
Publications
Xie Y, Clarke BP, Xie D, Mei M, Bhat P, Hill PS, Angelos AE, Çagatay T, Haider M, Collier SE, Chambers MG, Aksenova V, Dasso M, Fontoura BMA, Ren Y. Structures and mRNP remodeling mechanism of the TREX-2 complex. Structure [print-electronic]. 2025 Mar 3/6/2025; 33(3): 566-582.e6-582.e6. PMID: 39862860, PMCID: PMC11890942, PII: S0969-2126(24)00581-1, DOI: 10.1016/j.str.2024.12.019, ISSN: 1878-4186.
Clarke BP, Angelos AE, Mei M, Hill PS, Xie Y, Ren Y. Cryo-EM structure of the CBC-ALYREF complex. Elife. 2024 Sep 9/16/2024; 12: PMID: 39282949, PMCID: PMC11405014, PII: 91432, DOI: 10.7554/eLife.91432, ISSN: 2050-084X.
Xie Y, Gao S, Zhang K, Bhat P, Clarke BP, Batten K, Mei M, Gazzara M, Shay JW, Lynch KW, Angelos AE, Hill PS, Ivey AL, Fontoura BMA, Ren Y. Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Cell Rep [print-electronic]. 2023 Aug 8/29/2023; 42(8): 112988. PMID: 37578863, PMCID: PMC10508174, PII: S2211-1247(23)00999-3, DOI: 10.1016/j.celrep.2023.112988, ISSN: 2211-1247.
Xie Y, Clarke BP, Kim YJ, Ivey AL, Hill PS, Shi Y, Ren Y. Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Elife. 2021 Mar 3/31/2021; 10: PMID: 33787496, PMCID: PMC8043747, PII: 65699, DOI: 10.7554/eLife.65699, ISSN: 2050-084X.
Xie Y, Lord CL, Clarke BP, Ivey AL, Hill PS, McDonald WH, Wente SR, Ren Y. Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex. Proc Natl Acad Sci U S A. 2021 Jan 1/19/2021; 118(3): PMID: 33431688, PMCID: PMC7826397, PII: 2019163118, DOI: 10.1073/pnas.2019163118, ISSN: 1091-6490.
Hale AT, Clarke BP, York JD. Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells. Methods Mol Biol. 2020; 2091: 83-92. PMID: 31773572, PMCID: PMC7293352, DOI: 10.1007/978-1-0716-0167-9_7, ISSN: 1940-6029.
Clarke BP, Logeman BL, Hale AT, Luka Z, York JD. A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria. Adv Biol Regul [print-electronic]. 2019 Aug; 73: 100637. PMID: 31378699, PMCID: PMC7216163, PII: S2212-4926(19)30058-2, DOI: 10.1016/j.jbior.2019.100637, ISSN: 2212-4934.
Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell [print-electronic]. 2018 Jun 6/7/2018; 70(5): 936-948.e7-948.e7. PMID: 29883610, PMCID: PMC5994928, PII: S1097-2765(18)30360-5, DOI: 10.1016/j.molcel.2018.05.010, ISSN: 1097-4164.
Clarke BP, Angelos AE, Mei M, Hill PS, Xie Y, Ren Y. Cryo-EM structure of the CBC-ALYREF complex. Elife. 2024 Sep 9/16/2024; 12: PMID: 39282949, PMCID: PMC11405014, PII: 91432, DOI: 10.7554/eLife.91432, ISSN: 2050-084X.
Xie Y, Gao S, Zhang K, Bhat P, Clarke BP, Batten K, Mei M, Gazzara M, Shay JW, Lynch KW, Angelos AE, Hill PS, Ivey AL, Fontoura BMA, Ren Y. Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Cell Rep [print-electronic]. 2023 Aug 8/29/2023; 42(8): 112988. PMID: 37578863, PMCID: PMC10508174, PII: S2211-1247(23)00999-3, DOI: 10.1016/j.celrep.2023.112988, ISSN: 2211-1247.
Xie Y, Clarke BP, Kim YJ, Ivey AL, Hill PS, Shi Y, Ren Y. Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Elife. 2021 Mar 3/31/2021; 10: PMID: 33787496, PMCID: PMC8043747, PII: 65699, DOI: 10.7554/eLife.65699, ISSN: 2050-084X.
Xie Y, Lord CL, Clarke BP, Ivey AL, Hill PS, McDonald WH, Wente SR, Ren Y. Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex. Proc Natl Acad Sci U S A. 2021 Jan 1/19/2021; 118(3): PMID: 33431688, PMCID: PMC7826397, PII: 2019163118, DOI: 10.1073/pnas.2019163118, ISSN: 1091-6490.
Hale AT, Clarke BP, York JD. Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells. Methods Mol Biol. 2020; 2091: 83-92. PMID: 31773572, PMCID: PMC7293352, DOI: 10.1007/978-1-0716-0167-9_7, ISSN: 1940-6029.
Clarke BP, Logeman BL, Hale AT, Luka Z, York JD. A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria. Adv Biol Regul [print-electronic]. 2019 Aug; 73: 100637. PMID: 31378699, PMCID: PMC7216163, PII: S2212-4926(19)30058-2, DOI: 10.1016/j.jbior.2019.100637, ISSN: 2212-4934.
Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell [print-electronic]. 2018 Jun 6/7/2018; 70(5): 936-948.e7-948.e7. PMID: 29883610, PMCID: PMC5994928, PII: S1097-2765(18)30360-5, DOI: 10.1016/j.molcel.2018.05.010, ISSN: 1097-4164.