Faculty Appointments
Assistant Professor of Medicine
Education
M.S., Clinical Investigation, University of Utah, Salt Lake City, UtahPh.D., Medicine/Cancer Biology, Wayne State University, Detroit, MichiganB.A., Medical Humanities and Mathematics, Benedictine University, Lisle, Illinois
Office Address
2525 West End Avenue, Suite 334-G
Nashville, TN 37203
Nashville, TN 37203
Research Keywords
cancer; early-onset; young-onset; adolescents; young adults; gastrointestinal cancer; colorectal cancer; appendiceal cancer; appendix cancer; gastric cancer; health disparities; obesity; adiposity; adipose tissue; energy balance; multi-omics.
Publications
Tapial S, García JL, Corchete L, Holowatyj AN, Pérez J, Rueda D, Urioste M, González-Sarmiento R, Perea J. Copy neutral loss of heterozygosity (cnLOH) patterns in synchronous colorectal cancer. Eur J Hum Genet [print-electronic]. 2020 Dec 12/2/2020; PMID: 33268847, PII: 10.1038/s41431-020-00774-w, DOI: 10.1038/s41431-020-00774-w, ISSN: 1476-5438.
Holowatyj AN, Eng C, Wen W, Idrees K, Guo X. Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age at Disease Onset. JAMA Netw Open. 2020 Dec 12/1/2020; 3(12): e2028644. PMID: 33295976, PMCID: PMC7726634, PII: 2773830, DOI: 10.1001/jamanetworkopen.2020.28644, ISSN: 2574-3805.
Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher KM, Gicquiau A, Gsur A, Habermann N, Herpel E, Kauczor HU, Keski-Rahkonen P, Kloor M, von Knebel-Doeberitz M, Kok DE, Nattenmüller J, Schirmacher P, Schneider M, Schrotz-King P, Simon T, Ueland PM, Viskochil R, Weijenberg MP, Scalbert A, Ulrich A, Bowers LW, Hursting SD, Ulrich CM. Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer. Cancer Prev Res (Phila) [print-electronic]. 2020 Oct; 13(10): 817-28. PMID: 32655010, PII: 1940-6207.CAPR-19-0538, DOI: 10.1158/1940-6207.CAPR-19-0538, ISSN: 1940-6215.
Holowatyj AN, Washington KM, Salaria SN, Lieu CH, Idrees K, Eng C. Early-Onset Appendiceal Cancer Survival by Race or Ethnicity in the United States. Gastroenterology [print-electronic]. 2020 Oct; 159(4): 1605-8. PMID: 32540351, PII: S0016-5085(20)34763-6, DOI: 10.1053/j.gastro.2020.06.011, ISSN: 1528-0012.
Holowatyj AN, Maude AS, Musa HS, Adamu A, Ibrahim S, Abdullahi A, Manko M, Aminu SM, Mohammed A, Idoko J, Ukwenya Y, Carpten J, Chandler PD, Hampel H, Faruk M. Patterns of Early-Onset Colorectal Cancer Among Nigerians and African Americans. JCO Glob Oncol. 2020 Oct; 6: 1647-55. PMID: 33141623, PMCID: PMC7713583, DOI: 10.1200/GO.20.00272, ISSN: 2687-8941.
Ose J, Holowatyj AN, Nattenmüller J, Gigic B, Lin T, Himbert C, Habermann N, Achaintre D, Scalbert A, Keski-Rahkonen P, Böhm J, Schrotz-King P, Schneider M, Ulrich A, Kampman E, Weijenberg M, Gsur A, Ueland PM, Kauczor HU, Ulrich CM. Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study. Cancer Causes Control [print-electronic]. 2020 Aug; 31(8): 723-35. PMID: 32430684, PII: 10.1007/s10552-020-01312-1, DOI: 10.1007/s10552-020-01312-1, ISSN: 1573-7225.
Holowatyj AN, Viskochil R, Ose D, Tingey B, Haaland B, Wilson D, Larson M, Feltz S, Lewis MA, Colman H, Ulrich CM. Diabetes, Body Fatness, and Insulin Prescription Among Adolescents and Young Adults with Cancer. J Adolesc Young Adult Oncol [print-electronic]. 2020 Jul 7/29/2020; PMID: 32749900, DOI: 10.1089/jayao.2020.0071, ISSN: 2156-535X.
Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher KM, Gicquiau A, Gsur A, Habermann N, Herpel E, Kauczor HU, Keski-Rahkonen P, Kloor M, von Knebel Doeberitz M, Kok DE, Nattenmüller J, Schirmacher P, Schneider M, Schrotz-King P, Simon T, Ueland PM, Viskochil R, Weijenberg MP, Scalbert A, Ulrich A, Bowers LW, Hursting SD, Ulrich CM. Multi-omics analysis reveals adipose-tumor crosstalk in colorectal cancer patients. Cancer Prev Res (Phila) [print-electronic]. 2020 Jul 7/12/2020; PMID: 32655010, PII: 1940-6207.CAPR-19-0538, DOI: 10.1158/1940-6207.CAPR-19-0538, ISSN: 1940-6215.
Geijsen AJMR, van Roekel EH, van Duijnhoven FJB, Achaintre D, Bachleitner-Hofmann T, Baierl A, Bergmann MM, Boehm J, Bours MJL, Brenner H, Breukink SO, Brezina S, Chang-Claude J, Herpel E, de Wilt JHW, Gicquiau A, Gigic B, Gumpenberger T, Hansson BME, Hoffmeister M, Holowatyj AN, Karner-Hanusch J, Keski-Rahkonen P, Keulen ETP, Koole JL, Leeb G, Ose J, Schirmacher P, Schneider MA, Schrotz-King P, Stift A, Ulvik A, Vogelaar FJ, Wesselink E, van Zutphen M, Gsur A, Habermann N, Kampman E, Scalbert A, Ueland PM, Ulrich AB, Ulrich CM, Weijenberg MP, Kok DE. Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium. Int. J. Cancer [print-electronic]. 2020 Jun 6/15/2020; 146(12): 3256-66. PMID: 31495913, PMCID: PMC7216900, DOI: 10.1002/ijc.32666, ISSN: 1097-0215.
Holowatyj AN, Washington KM, Salaria SN, Lieu CH, Idrees K, Eng C, Chandler PD, Hampel H, Martin RL, Lewis MA. Early-Onset Appendiceal Cancer Survival by Race or Ethnicity in the United States. Gastroenterology [print-electronic]. 2020 Jun 6/12/2020; PMID: 32540351, PII: S0016-5085(20)34763-6, DOI: 10.1053/j.gastro.2020.06.011, ISSN: 1528-0012.
Kiblawi R, Holowatyj AN, Gigic B, Brezina S, Geijsen AJMR, Ose J, Lin T, Hardikar S, Himbert C, Warby CA, Böhm J, Bours MJL, van Duijnhoven FJB, Gumpenberger T, Kok DE, Koole JL, van Roekel EH, Schrotz-King P, Ulvik A, Gsur A, Habermann N, Weijenberg MP, Ueland PM, Schneider M, Ulrich A, Ulrich CM, Playdon M. One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study. Br. J. Nutr [print-electronic]. 2020 May 5/28/2020; 123(10): 1187-200. PMID: 32019627, PII: S0007114520000422, DOI: 10.1017/S0007114520000422, ISSN: 1475-2662.
Kiblawi R, Holowatyj AN, Gigic B, Brezina S, Geijsen AJMR, Ose J, Lin T, Hardikar S, Himbert C, Warby CA, Böhm J, Bours MJL, van Duijnhoven FJB, Gumpenberger T, Kok DE, Koole JL, van Roekel EH, Schrotz-King P, Ulvik A, Gsur A, Habermann N, Weijenberg MP, Ueland PM, Schneider M, Ulrich A, Ulrich CM, Playdon M. One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study. Br J Nutr [print-electronic]. 2020 May 5/28/2020; 123(10): 1187-200. PMID: 32019627, PMCID: PMC7425811, PII: S0007114520000422, DOI: 10.1017/S0007114520000422, ISSN: 1475-2662.
Hardikar S, Albrechtsen RD, Achaintre D, Lin T, Pauleck S, Playdon M, Holowatyj AN, Gigic B, Schrotz-King P, Boehm J, Habermann N, Brezina S, Gsur A, van Roekel EH, Weijenberg MP, Keski-Rahkonen P, Scalbert A, Ose J, Ulrich CM. Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles. Metabolites. 2020 May 5/21/2020; 10(5): PMID: 32455751, PMCID: PMC7281389, PII: metabo10050213, DOI: 10.3390/metabo10050213, ISSN: 2218-1989.
Hardikar S, Albrechtsen RD, Achaintre D, Lin T, Pauleck S, Playdon M, Holowatyj AN, Gigic B, Schrotz-King P, Boehm J, Habermann N, Brezina S, Gsur A, van Roekel EH, Weijenberg MP, Keski-Rahkonen P, Scalbert A, Ose J, Ulrich CM. Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles. Metabolites. 2020 May 5/21/2020; 10(5): PMID: 32455751, PMCID: PMC7281389, PII: metabo10050213, DOI: 10.3390/metabo10050213, ISSN: 2218-1989.
Archambault AN, Su YR, Jeon J, Thomas M, Lin Y, Conti DV, Win AK, Sakoda LC, Lansdorp-Vogelaar I, Peterse EFP, Zauber AG, Duggan D, Holowatyj AN, Huyghe JR, Brenner H, Cotterchio M, Bézieau S, Schmit SL, Edlund CK, Southey MC, MacInnis RJ, Campbell PT, Chang-Claude J, Slattery ML, Chan AT, Joshi AD, Song M, Cao Y, Woods MO, White E, Weinstein SJ, Ulrich CM, Hoffmeister M, Bien SA, Harrison TA, Hampe J, Li CI, Schafmayer C, Offit K, Pharoah PD, Moreno V, Lindblom A, Wolk A, Wu AH, Li L, Gunter MJ, Gsur A, Keku TO, Pearlman R, Bishop DT, Castellví-Bel S, Moreira L, Vodicka P, Kampman E, Giles GG, Albanes D, Baron JA, Berndt SI, Brezina S, Buch S, Buchanan DD, Trichopoulou A, Severi G, Chirlaque MD, Sánchez MJ, Palli D, Kühn T, Murphy N, Cross AJ, Burnett-Hartman AN, Chanock SJ, de la Chapelle A, Easton DF, Elliott F, English DR, Feskens EJM, FitzGerald LM, Goodman PJ, Hopper JL, Hudson TJ, Hunter DJ, Jacobs EJ, Joshu CE, Küry S, Markowitz SD, Milne RL, Platz EA, Rennert G, Rennert HS, Schumacher FR, Sandler RS, Seminara D, Tangen CM, Thibodeau SN, Toland AE, van Duijnhoven FJB, Visvanathan K, Vodickova L, Potter JD, Männistö S, Weigl K, Figueiredo J, Martín V, Larsson SC, Parfrey PS, Huang WY, Lenz HJ, Castelao JE, Gago-Dominguez M, Muñoz-Garzón V, Mancao C, Haiman CA, Wilkens LR, Siegel E, Barry E, Younghusband B, Van Guelpen B, Harlid S, Zeleniuch-Jacquotte A, Liang PS, Du M, Casey G, Lindor NM, Le Marchand L, Gallinger SJ, Jenkins MA, Newcomb PA, Gruber SB, Schoen RE, Hampel H, Corley DA, Hsu L, Peters U, Hayes RB. Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer. Gastroenterology [print-electronic]. 2020 Apr; 158(5): 1274-1286.e12. PMID: 31866242, PMCID: PMC7103489, PII: S0016-5085(19)41937-9, DOI: 10.1053/j.gastro.2019.12.012, ISSN: 1528-0012.
Holowatyj AN, Gigic B, Herpel E, Scalbert A, Schneider M, Ulrich CM. Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis. Gastroenterology. 2020 Mar; 158(4): 1155-1158.e2. PMID: 31730769, PMCID: PMC7291587, PII: S0016-5085(19)41536-9, DOI: 10.1053/j.gastro.2019.11.012, ISSN: 1528-0012.
Beyerle J, Holowatyj AN, Haffa M, Frei E, Gigic B, Schrotz-King P, Boehm J, Habermann N, Stiborova M, Scherer D, Kölsch T, Skender S, Becker N, Herpel E, Schneider M, Ulrich A, Schirmacher P, Chang-Claude J, Brenner H, Hoffmeister M, Haug U, Owen RW, Ulrich CM. Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2020 Feb; 29(2): 460-9. PMID: 31740522, PMCID: PMC7007332, PII: 1055-9965.EPI-19-0449, DOI: 10.1158/1055-9965.EPI-19-0449, ISSN: 1538-7755.
Rogers CR, Moore JX, Qeadan F, Gu LY, Huntington MS, Holowatyj AN. Examining factors underlying geographic disparities in early-onset colorectal cancer survival among men in the United States. Am J Cancer Res. 2020; 10(5): 1592-607. PMID: 32509399, PMCID: PMC7269786, ISSN: 2156-6976.
Rogers CR, Moore JX, Qeadan F, Gu LY, Huntington MS, Holowatyj AN. Examining factors underlying geographic disparities in early-onset colorectal cancer survival among men in the United States. Am J Cancer Res. 2020; 10(5): 1592-607. PMID: 32509399, PMCID: PMC7269786, ISSN: 2156-6976.
Holowatyj AN, Ulrich CM, Lewis MA. Racial/Ethnic Patterns of Young-Onset Noncardia Gastric Cancer. Cancer Prev Res (Phila) [print-electronic]. 2019 Nov; 12(11): 771-80. PMID: 31420363, PMCID: PMC6825562, PII: 1940-6207.CAPR-19-0200, DOI: 10.1158/1940-6207.CAPR-19-0200, ISSN: 1940-6215.
Haffa M, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, Habermann N, Schrotz-King P, Böhm J, Brenner H, Schneider M, Ulrich A, Herpel E, Schirmacher P, Straub BK, Nattenmüller J, Kauczor HU, Lin T, Ball CR, Ulrich CM, Glimm H, Scherer D. Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer. J. Clin. Endocrinol. Metab. 2019 Nov 11/1/2019; 104(11): 5225-37. PMID: 31225875, PMCID: PMC6763280, PII: 5520799, DOI: 10.1210/jc.2019-00461, ISSN: 1945-7197.
Zhang P, Holowatyj AN, Ulrich CM, Edgar BA. Tumor suppressive autophagy in intestinal stem cells controls gut homeostasis. Autophagy [print-electronic]. 2019 Sep; 15(9): 1668-70. PMID: 31213134, PMCID: PMC6693466, DOI: 10.1080/15548627.2019.1633863, ISSN: 1554-8635.
Geijsen AJMR, Brezina S, Keski-Rahkonen P, Baierl A, Bachleitner-Hofmann T, Bergmann MM, Boehm J, Brenner H, Chang-Claude J, van Duijnhoven FJB, Gigic B, Gumpenberger T, Hofer P, Hoffmeister M, Holowatyj AN, Karner-Hanusch J, Kok DE, Leeb G, Ulvik A, Robinot N, Ose J, Stift A, Schrotz-King P, Ulrich AB, Ueland PM, Kampman E, Scalbert A, Habermann N, Gsur A, Ulrich CM. Plasma metabolites associated with colorectal cancer: A discovery-replication strategy. Int. J. Cancer [print-electronic]. 2019 Sep 9/1/2019; 145(5): 1221-31. PMID: 30665271, PMCID: PMC6614008, DOI: 10.1002/ijc.32146, ISSN: 1097-0215.
Holowatyj AN, Lewis MA, Pannier ST, Kirchhoff AC, Hardikar S, Figueiredo JC, Huang LC, Shibata D, Schmit SL, Ulrich CM. Clinicopathologic and Racial/Ethnic Differences of Colorectal Cancer Among Adolescents and Young Adults. Clin Transl Gastroenterol. 2019 Jul; 10(7): e00059. PMID: 31259751, PMCID: PMC6708666, DOI: 10.14309/ctg.0000000000000059, ISSN: 2155-384X.
Zhang P, Holowatyj AN, Roy T, Pronovost SM, Marchetti M, Liu H, Ulrich CM, Edgar BA. An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. Dev. Cell [print-electronic]. 2019 May 5/20/2019; 49(4): 574-589.e5. PMID: 31006650, PMCID: PMC6542281, PII: S1534-5807(19)30240-0, DOI: 10.1016/j.devcel.2019.03.029, ISSN: 1878-1551.
Holowatyj AN, Heath EI, Pappas LM, Ruterbusch JJ, Gorski DH, Triest JA, Park HK, Beebe-Dimmer JL, Schwartz AG, Cote ML, Schwartz KL. The Epidemiology of Cancer Among Homeless Adults in Metropolitan Detroit. JNCI Cancer Spectr [print-electronic]. 2019 Mar; 3(1): pkz006. PMID: 30944890, PMCID: PMC6433093, PII: pkz006, DOI: 10.1093/jncics/pkz006, ISSN: 2515-5091.
Himbert C, Ose J, Nattenmüller J, Warby CA, Holowatyj AN, Böhm J, Lin T, Haffa M, Gigic B, Hardikar S, Scherer D, Zielske L, Schrotz-King P, Kölsch T, Siegel EM, Shibata D, Ulrich A, Schneider M, Hursting SD, Kauczor HU, Ulrich CM. Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2019 Jan; 28(1): 76-82. PMID: 30333223, PMCID: PMC6324954, PII: 1055-9965.EPI-18-0654, DOI: 10.1158/1055-9965.EPI-18-0654, ISSN: 1538-7755.
Ulrich CM, Himbert C, Holowatyj AN, Hursting SD. Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Nat Rev Gastroenterol Hepatol. 2018 Nov; 15(11): 683-98. PMID: 30158569, PMCID: PMC6500387, PII: 10.1038/s41575-018-0053-2, DOI: 10.1038/s41575-018-0053-2, ISSN: 1759-5053.
Bock CH, Ruterbusch JJ, Holowatyj AN, Steck SE, Van Dyke AL, Ho WJ, Cote ML, Hofmann JN, Davis F, Graubard BI, Schwartz KL, Purdue MP. Renal cell carcinoma risk associated with lower intake of micronutrients. Cancer Med [print-electronic]. 2018 Aug; 7(8): 4087-97. PMID: 29968964, PMCID: PMC6089194, DOI: 10.1002/cam4.1639, ISSN: 2045-7634.
Holowatyj AN, Cote ML, Ruterbusch JJ, Ghanem K, Schwartz AG, Vigneau FD, Gorski DH, Purrington KS. Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer. J. Clin. Oncol [print-electronic]. 2018 Mar 3/1/2018; 36(7): 652-8. PMID: 29341832, PMCID: PMC6366808, DOI: 10.1200/JCO.2017.74.5448, ISSN: 1527-7755.
Holowatyj AN, Ruterbusch JJ, Ratnam M, Gorski DH, Cote ML. HER2 status and disparities in luminal breast cancers. Cancer Med [print-electronic]. 2016 Aug; 5(8): 2109-16. PMID: 27250116, PMCID: PMC4893351, DOI: 10.1002/cam4.757, ISSN: 2045-7634.
Holowatyj AN, Ruterbusch JJ, Rozek LS, Cote ML, Stoffel EM. Racial/Ethnic Disparities in Survival Among Patients With Young-Onset Colorectal Cancer. J. Clin. Oncol [print-electronic]. 2016 Jun 6/20/2016; 34(18): 2148-56. PMID: 27138583, PMCID: PMC4962705, PII: JCO.2015.65.0994, DOI: 10.1200/JCO.2015.65.0994, ISSN: 1527-7755.
Liu H, Liu L, Holowatyj A, Jiang Y, Yang ZQ. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Mol. Carcinog [print-electronic]. 2016 May; 55(5): 977-90. PMID: 26207617, PMCID: PMC4724550, DOI: 10.1002/mc.22341, ISSN: 1098-2744.
Liu L, Kimball S, Liu H, Holowatyj A, Yang ZQ. Genetic alterations of histone lysine methyltransferases and their significance in breast cancer. Oncotarget. 2015 Feb 2/10/2015; 6(4): 2466-82. PMID: 25537518, PMCID: PMC4385864, PII: 2967, DOI: 10.18632/oncotarget.2967, ISSN: 1949-2553.
Holowatyj A, Yang ZQ, Pile LA. Histone lysine demethylases in Drosophila melanogaster. Fly (Austin). 2015; 9(1): 36-44. PMID: 26207949, PMCID: PMC4594552, DOI: 10.1080/19336934.2015.1074787, ISSN: 1933-6942.
Ye Q, Holowatyj A, Wu J, Liu H, Zhang L, Suzuki T, Yang ZQ. Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. Am J Cancer Res. 2015; 5(4): 1519-30. PMID: 26101715, PMCID: PMC4473328, ISSN: 2156-6976.
Labbé RM, Holowatyj A, Yang ZQ. Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res. 2013; 6(1): 1-15. PMID: 24349617, PMCID: PMC3853420, ISSN: 1943-8141.
Sun LL, Holowatyj A, Xu XE, Wu JY, Wu ZY, Shen JH, Wang SH, Li EM, Yang ZQ, Xu LY. Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma. Am J Cancer Res. 2013; 3(5): 509-17. PMID: 24224128, PMCID: PMC3816970, ISSN: 2156-6976.
Hou J, Wu J, Dombkowski A, Zhang K, Holowatyj A, Boerner JL, Yang ZQ. Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. Am J Transl Res [print-electronic]. 2012; 4(3): 247-56. PMID: 22937203, PMCID: PMC3426386, ISSN: 1943-8141.
Holowatyj AN, Eng C, Wen W, Idrees K, Guo X. Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age at Disease Onset. JAMA Netw Open. 2020 Dec 12/1/2020; 3(12): e2028644. PMID: 33295976, PMCID: PMC7726634, PII: 2773830, DOI: 10.1001/jamanetworkopen.2020.28644, ISSN: 2574-3805.
Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher KM, Gicquiau A, Gsur A, Habermann N, Herpel E, Kauczor HU, Keski-Rahkonen P, Kloor M, von Knebel-Doeberitz M, Kok DE, Nattenmüller J, Schirmacher P, Schneider M, Schrotz-King P, Simon T, Ueland PM, Viskochil R, Weijenberg MP, Scalbert A, Ulrich A, Bowers LW, Hursting SD, Ulrich CM. Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer. Cancer Prev Res (Phila) [print-electronic]. 2020 Oct; 13(10): 817-28. PMID: 32655010, PII: 1940-6207.CAPR-19-0538, DOI: 10.1158/1940-6207.CAPR-19-0538, ISSN: 1940-6215.
Holowatyj AN, Washington KM, Salaria SN, Lieu CH, Idrees K, Eng C. Early-Onset Appendiceal Cancer Survival by Race or Ethnicity in the United States. Gastroenterology [print-electronic]. 2020 Oct; 159(4): 1605-8. PMID: 32540351, PII: S0016-5085(20)34763-6, DOI: 10.1053/j.gastro.2020.06.011, ISSN: 1528-0012.
Holowatyj AN, Maude AS, Musa HS, Adamu A, Ibrahim S, Abdullahi A, Manko M, Aminu SM, Mohammed A, Idoko J, Ukwenya Y, Carpten J, Chandler PD, Hampel H, Faruk M. Patterns of Early-Onset Colorectal Cancer Among Nigerians and African Americans. JCO Glob Oncol. 2020 Oct; 6: 1647-55. PMID: 33141623, PMCID: PMC7713583, DOI: 10.1200/GO.20.00272, ISSN: 2687-8941.
Ose J, Holowatyj AN, Nattenmüller J, Gigic B, Lin T, Himbert C, Habermann N, Achaintre D, Scalbert A, Keski-Rahkonen P, Böhm J, Schrotz-King P, Schneider M, Ulrich A, Kampman E, Weijenberg M, Gsur A, Ueland PM, Kauczor HU, Ulrich CM. Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study. Cancer Causes Control [print-electronic]. 2020 Aug; 31(8): 723-35. PMID: 32430684, PII: 10.1007/s10552-020-01312-1, DOI: 10.1007/s10552-020-01312-1, ISSN: 1573-7225.
Holowatyj AN, Viskochil R, Ose D, Tingey B, Haaland B, Wilson D, Larson M, Feltz S, Lewis MA, Colman H, Ulrich CM. Diabetes, Body Fatness, and Insulin Prescription Among Adolescents and Young Adults with Cancer. J Adolesc Young Adult Oncol [print-electronic]. 2020 Jul 7/29/2020; PMID: 32749900, DOI: 10.1089/jayao.2020.0071, ISSN: 2156-535X.
Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher KM, Gicquiau A, Gsur A, Habermann N, Herpel E, Kauczor HU, Keski-Rahkonen P, Kloor M, von Knebel Doeberitz M, Kok DE, Nattenmüller J, Schirmacher P, Schneider M, Schrotz-King P, Simon T, Ueland PM, Viskochil R, Weijenberg MP, Scalbert A, Ulrich A, Bowers LW, Hursting SD, Ulrich CM. Multi-omics analysis reveals adipose-tumor crosstalk in colorectal cancer patients. Cancer Prev Res (Phila) [print-electronic]. 2020 Jul 7/12/2020; PMID: 32655010, PII: 1940-6207.CAPR-19-0538, DOI: 10.1158/1940-6207.CAPR-19-0538, ISSN: 1940-6215.
Geijsen AJMR, van Roekel EH, van Duijnhoven FJB, Achaintre D, Bachleitner-Hofmann T, Baierl A, Bergmann MM, Boehm J, Bours MJL, Brenner H, Breukink SO, Brezina S, Chang-Claude J, Herpel E, de Wilt JHW, Gicquiau A, Gigic B, Gumpenberger T, Hansson BME, Hoffmeister M, Holowatyj AN, Karner-Hanusch J, Keski-Rahkonen P, Keulen ETP, Koole JL, Leeb G, Ose J, Schirmacher P, Schneider MA, Schrotz-King P, Stift A, Ulvik A, Vogelaar FJ, Wesselink E, van Zutphen M, Gsur A, Habermann N, Kampman E, Scalbert A, Ueland PM, Ulrich AB, Ulrich CM, Weijenberg MP, Kok DE. Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium. Int. J. Cancer [print-electronic]. 2020 Jun 6/15/2020; 146(12): 3256-66. PMID: 31495913, PMCID: PMC7216900, DOI: 10.1002/ijc.32666, ISSN: 1097-0215.
Holowatyj AN, Washington KM, Salaria SN, Lieu CH, Idrees K, Eng C, Chandler PD, Hampel H, Martin RL, Lewis MA. Early-Onset Appendiceal Cancer Survival by Race or Ethnicity in the United States. Gastroenterology [print-electronic]. 2020 Jun 6/12/2020; PMID: 32540351, PII: S0016-5085(20)34763-6, DOI: 10.1053/j.gastro.2020.06.011, ISSN: 1528-0012.
Kiblawi R, Holowatyj AN, Gigic B, Brezina S, Geijsen AJMR, Ose J, Lin T, Hardikar S, Himbert C, Warby CA, Böhm J, Bours MJL, van Duijnhoven FJB, Gumpenberger T, Kok DE, Koole JL, van Roekel EH, Schrotz-King P, Ulvik A, Gsur A, Habermann N, Weijenberg MP, Ueland PM, Schneider M, Ulrich A, Ulrich CM, Playdon M. One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study. Br. J. Nutr [print-electronic]. 2020 May 5/28/2020; 123(10): 1187-200. PMID: 32019627, PII: S0007114520000422, DOI: 10.1017/S0007114520000422, ISSN: 1475-2662.
Kiblawi R, Holowatyj AN, Gigic B, Brezina S, Geijsen AJMR, Ose J, Lin T, Hardikar S, Himbert C, Warby CA, Böhm J, Bours MJL, van Duijnhoven FJB, Gumpenberger T, Kok DE, Koole JL, van Roekel EH, Schrotz-King P, Ulvik A, Gsur A, Habermann N, Weijenberg MP, Ueland PM, Schneider M, Ulrich A, Ulrich CM, Playdon M. One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study. Br J Nutr [print-electronic]. 2020 May 5/28/2020; 123(10): 1187-200. PMID: 32019627, PMCID: PMC7425811, PII: S0007114520000422, DOI: 10.1017/S0007114520000422, ISSN: 1475-2662.
Hardikar S, Albrechtsen RD, Achaintre D, Lin T, Pauleck S, Playdon M, Holowatyj AN, Gigic B, Schrotz-King P, Boehm J, Habermann N, Brezina S, Gsur A, van Roekel EH, Weijenberg MP, Keski-Rahkonen P, Scalbert A, Ose J, Ulrich CM. Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles. Metabolites. 2020 May 5/21/2020; 10(5): PMID: 32455751, PMCID: PMC7281389, PII: metabo10050213, DOI: 10.3390/metabo10050213, ISSN: 2218-1989.
Hardikar S, Albrechtsen RD, Achaintre D, Lin T, Pauleck S, Playdon M, Holowatyj AN, Gigic B, Schrotz-King P, Boehm J, Habermann N, Brezina S, Gsur A, van Roekel EH, Weijenberg MP, Keski-Rahkonen P, Scalbert A, Ose J, Ulrich CM. Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles. Metabolites. 2020 May 5/21/2020; 10(5): PMID: 32455751, PMCID: PMC7281389, PII: metabo10050213, DOI: 10.3390/metabo10050213, ISSN: 2218-1989.
Archambault AN, Su YR, Jeon J, Thomas M, Lin Y, Conti DV, Win AK, Sakoda LC, Lansdorp-Vogelaar I, Peterse EFP, Zauber AG, Duggan D, Holowatyj AN, Huyghe JR, Brenner H, Cotterchio M, Bézieau S, Schmit SL, Edlund CK, Southey MC, MacInnis RJ, Campbell PT, Chang-Claude J, Slattery ML, Chan AT, Joshi AD, Song M, Cao Y, Woods MO, White E, Weinstein SJ, Ulrich CM, Hoffmeister M, Bien SA, Harrison TA, Hampe J, Li CI, Schafmayer C, Offit K, Pharoah PD, Moreno V, Lindblom A, Wolk A, Wu AH, Li L, Gunter MJ, Gsur A, Keku TO, Pearlman R, Bishop DT, Castellví-Bel S, Moreira L, Vodicka P, Kampman E, Giles GG, Albanes D, Baron JA, Berndt SI, Brezina S, Buch S, Buchanan DD, Trichopoulou A, Severi G, Chirlaque MD, Sánchez MJ, Palli D, Kühn T, Murphy N, Cross AJ, Burnett-Hartman AN, Chanock SJ, de la Chapelle A, Easton DF, Elliott F, English DR, Feskens EJM, FitzGerald LM, Goodman PJ, Hopper JL, Hudson TJ, Hunter DJ, Jacobs EJ, Joshu CE, Küry S, Markowitz SD, Milne RL, Platz EA, Rennert G, Rennert HS, Schumacher FR, Sandler RS, Seminara D, Tangen CM, Thibodeau SN, Toland AE, van Duijnhoven FJB, Visvanathan K, Vodickova L, Potter JD, Männistö S, Weigl K, Figueiredo J, Martín V, Larsson SC, Parfrey PS, Huang WY, Lenz HJ, Castelao JE, Gago-Dominguez M, Muñoz-Garzón V, Mancao C, Haiman CA, Wilkens LR, Siegel E, Barry E, Younghusband B, Van Guelpen B, Harlid S, Zeleniuch-Jacquotte A, Liang PS, Du M, Casey G, Lindor NM, Le Marchand L, Gallinger SJ, Jenkins MA, Newcomb PA, Gruber SB, Schoen RE, Hampel H, Corley DA, Hsu L, Peters U, Hayes RB. Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer. Gastroenterology [print-electronic]. 2020 Apr; 158(5): 1274-1286.e12. PMID: 31866242, PMCID: PMC7103489, PII: S0016-5085(19)41937-9, DOI: 10.1053/j.gastro.2019.12.012, ISSN: 1528-0012.
Holowatyj AN, Gigic B, Herpel E, Scalbert A, Schneider M, Ulrich CM. Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis. Gastroenterology. 2020 Mar; 158(4): 1155-1158.e2. PMID: 31730769, PMCID: PMC7291587, PII: S0016-5085(19)41536-9, DOI: 10.1053/j.gastro.2019.11.012, ISSN: 1528-0012.
Beyerle J, Holowatyj AN, Haffa M, Frei E, Gigic B, Schrotz-King P, Boehm J, Habermann N, Stiborova M, Scherer D, Kölsch T, Skender S, Becker N, Herpel E, Schneider M, Ulrich A, Schirmacher P, Chang-Claude J, Brenner H, Hoffmeister M, Haug U, Owen RW, Ulrich CM. Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2020 Feb; 29(2): 460-9. PMID: 31740522, PMCID: PMC7007332, PII: 1055-9965.EPI-19-0449, DOI: 10.1158/1055-9965.EPI-19-0449, ISSN: 1538-7755.
Rogers CR, Moore JX, Qeadan F, Gu LY, Huntington MS, Holowatyj AN. Examining factors underlying geographic disparities in early-onset colorectal cancer survival among men in the United States. Am J Cancer Res. 2020; 10(5): 1592-607. PMID: 32509399, PMCID: PMC7269786, ISSN: 2156-6976.
Rogers CR, Moore JX, Qeadan F, Gu LY, Huntington MS, Holowatyj AN. Examining factors underlying geographic disparities in early-onset colorectal cancer survival among men in the United States. Am J Cancer Res. 2020; 10(5): 1592-607. PMID: 32509399, PMCID: PMC7269786, ISSN: 2156-6976.
Holowatyj AN, Ulrich CM, Lewis MA. Racial/Ethnic Patterns of Young-Onset Noncardia Gastric Cancer. Cancer Prev Res (Phila) [print-electronic]. 2019 Nov; 12(11): 771-80. PMID: 31420363, PMCID: PMC6825562, PII: 1940-6207.CAPR-19-0200, DOI: 10.1158/1940-6207.CAPR-19-0200, ISSN: 1940-6215.
Haffa M, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, Habermann N, Schrotz-King P, Böhm J, Brenner H, Schneider M, Ulrich A, Herpel E, Schirmacher P, Straub BK, Nattenmüller J, Kauczor HU, Lin T, Ball CR, Ulrich CM, Glimm H, Scherer D. Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer. J. Clin. Endocrinol. Metab. 2019 Nov 11/1/2019; 104(11): 5225-37. PMID: 31225875, PMCID: PMC6763280, PII: 5520799, DOI: 10.1210/jc.2019-00461, ISSN: 1945-7197.
Zhang P, Holowatyj AN, Ulrich CM, Edgar BA. Tumor suppressive autophagy in intestinal stem cells controls gut homeostasis. Autophagy [print-electronic]. 2019 Sep; 15(9): 1668-70. PMID: 31213134, PMCID: PMC6693466, DOI: 10.1080/15548627.2019.1633863, ISSN: 1554-8635.
Geijsen AJMR, Brezina S, Keski-Rahkonen P, Baierl A, Bachleitner-Hofmann T, Bergmann MM, Boehm J, Brenner H, Chang-Claude J, van Duijnhoven FJB, Gigic B, Gumpenberger T, Hofer P, Hoffmeister M, Holowatyj AN, Karner-Hanusch J, Kok DE, Leeb G, Ulvik A, Robinot N, Ose J, Stift A, Schrotz-King P, Ulrich AB, Ueland PM, Kampman E, Scalbert A, Habermann N, Gsur A, Ulrich CM. Plasma metabolites associated with colorectal cancer: A discovery-replication strategy. Int. J. Cancer [print-electronic]. 2019 Sep 9/1/2019; 145(5): 1221-31. PMID: 30665271, PMCID: PMC6614008, DOI: 10.1002/ijc.32146, ISSN: 1097-0215.
Holowatyj AN, Lewis MA, Pannier ST, Kirchhoff AC, Hardikar S, Figueiredo JC, Huang LC, Shibata D, Schmit SL, Ulrich CM. Clinicopathologic and Racial/Ethnic Differences of Colorectal Cancer Among Adolescents and Young Adults. Clin Transl Gastroenterol. 2019 Jul; 10(7): e00059. PMID: 31259751, PMCID: PMC6708666, DOI: 10.14309/ctg.0000000000000059, ISSN: 2155-384X.
Zhang P, Holowatyj AN, Roy T, Pronovost SM, Marchetti M, Liu H, Ulrich CM, Edgar BA. An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. Dev. Cell [print-electronic]. 2019 May 5/20/2019; 49(4): 574-589.e5. PMID: 31006650, PMCID: PMC6542281, PII: S1534-5807(19)30240-0, DOI: 10.1016/j.devcel.2019.03.029, ISSN: 1878-1551.
Holowatyj AN, Heath EI, Pappas LM, Ruterbusch JJ, Gorski DH, Triest JA, Park HK, Beebe-Dimmer JL, Schwartz AG, Cote ML, Schwartz KL. The Epidemiology of Cancer Among Homeless Adults in Metropolitan Detroit. JNCI Cancer Spectr [print-electronic]. 2019 Mar; 3(1): pkz006. PMID: 30944890, PMCID: PMC6433093, PII: pkz006, DOI: 10.1093/jncics/pkz006, ISSN: 2515-5091.
Himbert C, Ose J, Nattenmüller J, Warby CA, Holowatyj AN, Böhm J, Lin T, Haffa M, Gigic B, Hardikar S, Scherer D, Zielske L, Schrotz-King P, Kölsch T, Siegel EM, Shibata D, Ulrich A, Schneider M, Hursting SD, Kauczor HU, Ulrich CM. Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2019 Jan; 28(1): 76-82. PMID: 30333223, PMCID: PMC6324954, PII: 1055-9965.EPI-18-0654, DOI: 10.1158/1055-9965.EPI-18-0654, ISSN: 1538-7755.
Ulrich CM, Himbert C, Holowatyj AN, Hursting SD. Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Nat Rev Gastroenterol Hepatol. 2018 Nov; 15(11): 683-98. PMID: 30158569, PMCID: PMC6500387, PII: 10.1038/s41575-018-0053-2, DOI: 10.1038/s41575-018-0053-2, ISSN: 1759-5053.
Bock CH, Ruterbusch JJ, Holowatyj AN, Steck SE, Van Dyke AL, Ho WJ, Cote ML, Hofmann JN, Davis F, Graubard BI, Schwartz KL, Purdue MP. Renal cell carcinoma risk associated with lower intake of micronutrients. Cancer Med [print-electronic]. 2018 Aug; 7(8): 4087-97. PMID: 29968964, PMCID: PMC6089194, DOI: 10.1002/cam4.1639, ISSN: 2045-7634.
Holowatyj AN, Cote ML, Ruterbusch JJ, Ghanem K, Schwartz AG, Vigneau FD, Gorski DH, Purrington KS. Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer. J. Clin. Oncol [print-electronic]. 2018 Mar 3/1/2018; 36(7): 652-8. PMID: 29341832, PMCID: PMC6366808, DOI: 10.1200/JCO.2017.74.5448, ISSN: 1527-7755.
Holowatyj AN, Ruterbusch JJ, Ratnam M, Gorski DH, Cote ML. HER2 status and disparities in luminal breast cancers. Cancer Med [print-electronic]. 2016 Aug; 5(8): 2109-16. PMID: 27250116, PMCID: PMC4893351, DOI: 10.1002/cam4.757, ISSN: 2045-7634.
Holowatyj AN, Ruterbusch JJ, Rozek LS, Cote ML, Stoffel EM. Racial/Ethnic Disparities in Survival Among Patients With Young-Onset Colorectal Cancer. J. Clin. Oncol [print-electronic]. 2016 Jun 6/20/2016; 34(18): 2148-56. PMID: 27138583, PMCID: PMC4962705, PII: JCO.2015.65.0994, DOI: 10.1200/JCO.2015.65.0994, ISSN: 1527-7755.
Liu H, Liu L, Holowatyj A, Jiang Y, Yang ZQ. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Mol. Carcinog [print-electronic]. 2016 May; 55(5): 977-90. PMID: 26207617, PMCID: PMC4724550, DOI: 10.1002/mc.22341, ISSN: 1098-2744.
Liu L, Kimball S, Liu H, Holowatyj A, Yang ZQ. Genetic alterations of histone lysine methyltransferases and their significance in breast cancer. Oncotarget. 2015 Feb 2/10/2015; 6(4): 2466-82. PMID: 25537518, PMCID: PMC4385864, PII: 2967, DOI: 10.18632/oncotarget.2967, ISSN: 1949-2553.
Holowatyj A, Yang ZQ, Pile LA. Histone lysine demethylases in Drosophila melanogaster. Fly (Austin). 2015; 9(1): 36-44. PMID: 26207949, PMCID: PMC4594552, DOI: 10.1080/19336934.2015.1074787, ISSN: 1933-6942.
Ye Q, Holowatyj A, Wu J, Liu H, Zhang L, Suzuki T, Yang ZQ. Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. Am J Cancer Res. 2015; 5(4): 1519-30. PMID: 26101715, PMCID: PMC4473328, ISSN: 2156-6976.
Labbé RM, Holowatyj A, Yang ZQ. Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res. 2013; 6(1): 1-15. PMID: 24349617, PMCID: PMC3853420, ISSN: 1943-8141.
Sun LL, Holowatyj A, Xu XE, Wu JY, Wu ZY, Shen JH, Wang SH, Li EM, Yang ZQ, Xu LY. Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma. Am J Cancer Res. 2013; 3(5): 509-17. PMID: 24224128, PMCID: PMC3816970, ISSN: 2156-6976.
Hou J, Wu J, Dombkowski A, Zhang K, Holowatyj A, Boerner JL, Yang ZQ. Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. Am J Transl Res [print-electronic]. 2012; 4(3): 247-56. PMID: 22937203, PMCID: PMC3426386, ISSN: 1943-8141.