Alexander G. Bick, Ph.D., M.D.

Associate Professor

alexander.g.bick@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.D., Harvard University, Cambridge, MassachusettsPh.D., Genetics, Harvard University, Cambridge, MassachusettsS.B., Engineering Sciences, Harvard University, Cambridge, MassachusettsS.M., Engineering and Applied Science, Harvard University, Cambridge, Massachusetts
Research Description
Dr. Bick is a physician-scientist working in the field of human genomics. His scientific observations have advanced our understanding of the genetic basis for cardiovascular disease, characterized molecular disease mechanisms and identified both the promise and limitations of translating genomic findings into routine medical practice. He has a particular interest in understanding how the interplay between inherited germline genetic factors and acquired somatic mutations contributes to disease. His approach has been highly collaborative and multidisciplinary – combining human genomics and statistical genetics with in-vitro and in-vivo characterization of model systems and human samples.

Dr Bick’s current scientific focus is on clonal hematopoiesis, a unifying feature of aging diseases as diverse as cardiovascular disease and cancer. He has recently demonstrated that clonal hematopoiesis is virtually absent in adults under 40, but found in >10% of adults over 70 and confers a 10-fold increased risk of blood cancers, 2-fold increased risk of heart attack and 1.5-fold increased risk of death. Dr. Bick is focused on identifying the causes and consequences of clonal hematopoiesis with a goal of developing new treatments targeting clonal hematopoiesis.
Clinical Description
In parallel with his research, Dr. Bick completed clinical training in Internal Medicine at Massachusetts General Hospital with a specialization in genomic medicine. He looks forward to seeing patients in the Vanderbilt Genomics and Therapeutics Clinic and aims to translate what is learned from his research studies back to the care of his patients.
Research Keywords
Human Genetics, Clonal Hematopoiesis, Cardiovascular disease,
Clinical Research Keywords
Preventative Genomic Medicine, Clonal Hematopoiesis of Indeterminate Potential (CHIP), Polygenic risk scores
Publications
Hung AM, Assimon VA, Chen HC, Yu Z, Vlasschaert C, Triozzi JL, Chan H, Wheless L, Wilson O, Shah SC, Mack T, Thompson T, Matheny ME, Chandrasekar S, Mozaffari SV, Chung CP, Tsao P, Susztak K, Siew ED, Estrada K, Gaziano JM, Graham RR, Tao R, Hoek M, Robinson-Cohen C, Green EM, Bick AG, . Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease. J Am Soc Nephrol [print-electronic]. 2023 Oct 10/6/2023; PMID: 37798822, PII: 00001751-990000000-00181, DOI: 10.1681/ASN.0000000000000219, ISSN: 1533-3450.

Yun JH, Khan MAW, Ghosh A, Hobbs BD, Castaldi PJ, Hersh CP, Miller PG, Cool CD, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner GJ, Brown K, Wise R, Martinez FJ, Silverman EK, DeMeo D, Cho MH, Bick AG, . Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function. Am J Respir Crit Care Med [print-electronic]. 2023 Oct 10/3/2023; PMID: 37788444, DOI: 10.1164/rccm.202303-0395OC, ISSN: 1535-4970.

Leiser CL, Whitsel EA, Reiner A, Rich SS, Rotter JI, Taylor KD, Tracy RP, Kooperberg C, Smith AV, Manson JE, Mychaleckyj JC, Bick AG, Szpiro AA, Kaufman JD. Associations between Ambient Air Pollutants and Clonal Hematopoiesis of Indeterminate Potential. Cancer Epidemiol Biomarkers Prev. 2023 Oct 10/2/2023; 32(10): 1470-3. PMID: 37466697, PII: 727866, DOI: 10.1158/1055-9965.EPI-23-0305, ISSN: 1538-7755.

Tobias DK, Manning AK, Wessel J, Raghavan S, Westerman KE, Bick AG, Dicorpo D, Whitsel EA, Collins J, Correa A, Cupples LA, Dupuis J, Goodarzi MO, Guo X, Howard B, Lange LA, Liu S, Raffield LM, Reiner AP, Rich SS, Taylor KD, Tinker L, Wilson JG, Wu P, Carson AP, Vasan RS, Fornage M, Psaty BM, Kooperberg C, Rotter JI, Meigs J, Manson JE, . Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk. Diabetes Care [print-electronic]. 2023 Sep 9/27/2023; PMID: 37756531, PII: 153672, DOI: 10.2337/dc23-0805, ISSN: 1935-5548.

Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P. Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. J Clin Invest. 2023 Sep 9/15/2023; 133(18): PMID: 37498674, PMCID: PMC10503804, PII: 168597, DOI: 10.1172/JCI168597, ISSN: 1558-8238.

Vlasschaert C, Akwo E, Robinson-Cohen C, Cook EK, Lanktree MB, Rauh MJ, Bick AG. Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank. Leukemia [print-electronic]. 2023 Sep 9/9/2023; PMID: 37689824, PII: 10.1038/s41375-023-02023-7, DOI: 10.1038/s41375-023-02023-7, ISSN: 1476-5551.

Deflaux N, Selvaraj MS, Condon HR, Mayo K, Haidermota S, Basford MA, Lunt C, Philippakis AA, Roden DM, Denny JC, Musick A, Collins R, Allen N, Effingham M, Glazer D, Natarajan P, Bick AG. Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis. Nat Commun. 2023 Sep 9/5/2023; 14(1): 5419. PMID: 37669985, PMCID: PMC10480504, PII: 10.1038/s41467-023-41185-x, DOI: 10.1038/s41467-023-41185-x, ISSN: 2041-1723.

Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC. Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women. Circ Res [print-electronic]. 2023 Aug 8/18/2023; 133(5): 376-86. PMID: 37489536, PMCID: PMC10528840, DOI: 10.1161/CIRCRESAHA.123.322984, ISSN: 1524-4571.

Amancherla K, Schlendorf KH, Vlasschaert C, Lowery BD, Wells QS, See SB, Zorn E, Colombo PC, Reilly MP, Lindenfeld J, Uriel N, Freedman JE, Shah RV, Moslehi J, Bick AG, Clerkin K. Clonal hematopoiesis of indeterminate potential and outcomes after heart transplantation: A multicenter study. Am J Transplant [print-electronic]. 2023 Aug; 23(8): 1256-63. PMID: 37156299, PMCID: PMC10524751, PII: S1600-6135(23)00454-9, DOI: 10.1016/j.ajt.2023.04.028, ISSN: 1600-6143.

Gibson CJ, Fell G, Sella T, Sperling AS, Snow C, Rosenberg SM, Kirkner G, Patel A, Dillon D, Bick AG, Neuberg D, Partridge AH, Miller PG. Clonal Hematopoiesis in Young Women Treated for Breast Cancer. Clin Cancer Res. 2023 Jul 7/5/2023; 29(13): 2551-8. PMID: 37115512, PMCID: PMC10330424, PII: 726205, DOI: 10.1158/1078-0432.CCR-23-0050, ISSN: 1557-3265.

Schuermans A, Nakao T, Ruan Y, Koyama S, Yu Z, Uddin MM, Haidermota S, Hornsby W, Lewandowski AJ, Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC. Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood. J Am Heart Assoc [print-electronic]. 2023 Jul 7/4/2023; 12(13): e030220. PMID: 37345823, PMCID: PMC10356089, DOI: 10.1161/JAHA.123.030220, ISSN: 2047-9980.

Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W, , Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S. Clonal hematopoiesis is associated with protection from Alzheimer's disease. Nat Med [print-electronic]. 2023 Jul; 29(7): 1662-70. PMID: 37322115, PMCID: PMC10353941, PII: 10.1038/s41591-023-02397-2, DOI: 10.1038/s41591-023-02397-2, ISSN: 1546-170X.

Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C, , Ebert BL, Natarajan P. Author Correction: Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023 Jul; 619(7970): E47. PMID: 37400552, PII: 10.1038/s41586-023-06375-z, DOI: 10.1038/s41586-023-06375-z, ISSN: 1476-4687.

Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, Pandhiri TR, Dave UP, Yellapu NK, Zhou X, Zhang C, Sandusky GE, Yu Z, Honigberg MC, Bick AG, Griffin GK, Niroula A, Ebert BL, Paczesny S, Natarajan P, Kapur R. Obesity-induced inflammation exacerbates clonal hematopoiesis. J Clin Invest. 2023 Jun 6/1/2023; 133(11): PMID: 37071471, PMCID: PMC10231999, PII: 163968, DOI: 10.1172/JCI163968, ISSN: 1558-8238.

Liu W, Yalcinkaya M, Maestre IF, Olszewska M, Ampomah PB, Heimlich JB, Wang R, Vela PS, Xiao T, Bick AG, Levine R, Papapetrou EP, Libby P, Tabas I, Wang N, Tall AR. Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis. Nat Cardiovasc Res [print-electronic]. 2023 Jun; 2(6): 572-86. PMID: 37539077, PMCID: PMC10399458, DOI: 10.1038/s44161-023-00281-3, ISSN: 2731-0590.

Gumuser ED, Schuermans A, Cho SMJ, Sporn ZA, Uddin MM, Paruchuri K, Nakao T, Yu Z, Haidermota S, Hornsby W, Weeks LD, Niroula A, Jaiswal S, Libby P, Ebert BL, Bick AG, Natarajan P, Honigberg MC. Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease. J Am Coll Cardiol. 2023 May 5/23/2023; 81(20): 1996-2009. PMID: 37197843, PMCID: PMC10249057, PII: S0735-1097(23)05158-6, DOI: 10.1016/j.jacc.2023.03.401, ISSN: 1558-3597.

Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, Sharber B, Silver AJ, Xu Y, Savona M, Gibson C, Lanktree MB, Rauh MJ, Ebert BL, Natarajan P, Jaiswal S, Bick AG. A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Blood. 2023 May 5/4/2023; 141(18): 2214-23. PMID: 36652671, PMCID: PMC10273159, PII: S0006-4971(23)00143-X, DOI: 10.1182/blood.2022018825, ISSN: 1528-0020.

Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL. Prediction of risk for myeloid malignancy in clonal hematopoiesis. NEJM Evid [print-electronic]. 2023 May; 2(5): PMID: 37483562, PMCID: PMC10361696, DOI: 10.1056/evidoa2200310, ISSN: 2766-5526.

Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, Cade BE, Gilliland FD, Chen Z, Gauderman WJ, Kumar R, Grammer L, Schleimer RP, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Weiss ST, Lasky-Su J, DeMeo DL, Palmer ND, Freedman BI, Bowden DW, Cho MH, Vasan RS, Johnson AD, Yanek LR, Becker LC, Kardia S, He J, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Manichaikul AW, Konkle BA, Johnsen JM, Wheeler MM, Custer BS, Duggirala R, Curran JE, Blangero J, Gui H, Xiao S, Williams LK, Meyers DA, Li X, Ortega V, McGarvey S, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Darbar D, Roden D, Albert C, Kooperberg C, Desai P, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Mathias R, Natarajan P, Jaiswal S, Reiner AP, Bick AG, . The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Sci Adv [print-electronic]. 2023 Apr 4/28/2023; 9(17): eabm4945. PMID: 37126548, PMCID: PMC10132750, DOI: 10.1126/sciadv.abm4945, ISSN: 2375-2548.

Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C, , Ebert BL, Natarajan P. Clonal haematopoiesis and risk of chronic liver disease. Nature [print-electronic]. 2023 Apr; 616(7958): 747-54. PMID: 37046084, PMCID: PMC10405350, PII: 10.1038/s41586-023-05857-4, DOI: 10.1038/s41586-023-05857-4, ISSN: 1476-4687.

Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM, Luna SE, Prothro KP, Mitchell SR, Laurie CA, Broome JG, Taylor KD, Guo X, Sinner MF, von Falkenhausen AS, Kääb S, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Hou L, Lloyd-Jones DM, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Palmer ND, Freedman BI, Bowden DW, Cho MH, DeMeo DL, Vasan RS, Yanek LR, Becker LC, Kardia SLR, Peyser PA, He J, Rienstra M, Van der Harst P, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Cutler MJ, Knight S, Muhlestein JB, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Tracy RP, Konkle BA, Johnsen JM, Wheeler MM, Smith JG, Melander O, Nilsson PM, Custer BS, Duggirala R, Curran JE, Blangero J, McGarvey S, Williams LK, Xiao S, Yang M, Gu CC, Chen YI, Lee WJ, Marcus GM, Kane JP, Pullinger CR, Shoemaker MB, Darbar D, Roden DM, Albert C, Kooperberg C, Zhou Y, Manson JE, Desai P, Johnson AD, Mathias RA, , Blackwell TW, Abecasis GR, Smith AV, Kang HM, Satpathy AT, Natarajan P, Kitzman JO, Whitsel EA, Reiner AP, Bick AG, Jaiswal S. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Nature [print-electronic]. 2023 Apr; 616(7958): 755-63. PMID: 37046083, PMCID: PMC10360040, PII: 10.1038/s41586-023-05806-1, DOI: 10.1038/s41586-023-05806-1, ISSN: 1476-4687.

Sochacki AL, Bejan CA, Zhao S, Patel A, Kishtagari A, Spaulding TP, Silver AJ, Stockton SS, Pugh K, Dorand RD, Bhatta M, Strayer N, Zhang S, Snider CA, Stricker T, Nazha A, Bick AG, Xu Y, Savona MR. Patient-specific comorbidities as prognostic variables for survival in myelofibrosis. Blood Adv. 2023 Mar 3/14/2023; 7(5): 756-67. PMID: 35420683, PMCID: PMC9989522, PII: 484926, DOI: 10.1182/bloodadvances.2021006318, ISSN: 2473-9537.

Kestenbaum B, Bick AG, Vlasschaert C, Rauh MJ, Lanktree MB, Franceschini N, Shoemaker MB, Harris RC, Psaty BM, Köttgen A, Natarajan P, Robinson-Cohen C. Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population. Am J Kidney Dis [print-electronic]. 2023 Mar; 81(3): 329-35. PMID: 36241009, PMCID: PMC9974853, PII: S0272-6386(22)00925-8, DOI: 10.1053/j.ajkd.2022.08.014, ISSN: 1523-6838.

Vlasschaert C, Heimlich JB, Rauh MJ, Natarajan P, Bick AG. Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank [letter]. Circulation [print-electronic]. 2023 Jan 1/24/2023; 147(4): 358-60. PMID: 36689568, PMCID: PMC9883044, DOI: 10.1161/CIRCULATIONAHA.122.062126, ISSN: 1524-4539.

von Beck K, von Beck T, Ferrell PB, Bick AG, Kishtagari A. Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment. Blood Cancer J. 2023 Jan 1/4/2023; 13(1): 5. PMID: 36599826, PMCID: PMC9813350, PII: 10.1038/s41408-022-00773-8, DOI: 10.1038/s41408-022-00773-8, ISSN: 2044-5385.

Miller PG, Fell GG, Foy BH, Scherer AK, Gibson CJ, Sperling AS, Burugula BB, Nakao T, Uddin MM, Warren H, Bry L, Pozdnyakova O, Frigault MJ, Bick AG, Neuberg D, Higgins JM, Mansour MK, Natarajan P, Kim AS, Kitzman JO, Ebert BL. Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19. Blood. 2022 Nov 11/3/2022; 140(18): 1993-7. PMID: 36096050, PMCID: PMC9474399, PII: S0006-4971(22)01209-5, DOI: 10.1182/blood.2022018052, ISSN: 1528-0020.

Uddin MDM, Nguyen NQH, Yu B, Brody JA, Pampana A, Nakao T, Fornage M, Bressler J, Sotoodehnia N, Weinstock JS, Honigberg MC, Nachun D, Bhattacharya R, Griffin GK, Chander V, Gibbs RA, Rotter JI, Liu C, Baccarelli AA, Chasman DI, Whitsel EA, Kiel DP, Murabito JM, Boerwinkle E, Ebert BL, Jaiswal S, Floyd JS, Bick AG, Ballantyne CM, Psaty BM, Natarajan P, Conneely KN. Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. Nat Commun. 2022 Sep 9/12/2022; 13(1): 5350. PMID: 36097025, PMCID: PMC9468335, PII: 10.1038/s41467-022-33093-3, DOI: 10.1038/s41467-022-33093-3, ISSN: 2041-1723.

Agrawal M, Niroula A, Cunin P, McConkey M, Shkolnik V, Kim PG, Wong WJ, Weeks LD, Lin AE, Miller PG, Gibson CJ, Sekar A, Schaefer IM, Neuberg D, Stone RM, Bick AG, Uddin MM, Griffin GK, Jaiswal S, Natarajan P, Nigrovic PA, Rao DA, Ebert BL. TET2-mutant clonal hematopoiesis and risk of gout. Blood. 2022 Sep 9/8/2022; 140(10): 1094-103. PMID: 35714308, PMCID: PMC9461470, PII: S0006-4971(22)00804-7, DOI: 10.1182/blood.2022015384, ISSN: 1528-0020.

Khan MAW, Bick AG. Expanding approaches to detect clonal hematopoiesis. Haematologica. 2022 Aug 8/1/2022; 107(8): 1739-40. PMID: 34587722, PMCID: PMC9335110, DOI: 10.3324/haematol.2021.279818, ISSN: 1592-8721.

Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, Klarin D, Levin MG, Sinnott-Armstrong N, Wojcik GL, Plomondon ME, Maddox TM, Waldo SW, Bick AG, Pyarajan S, Huang J, Song R, Ho YL, Buyske S, Kooperberg C, Haessler J, Loos RJF, Do R, Verbanck M, Chaudhary K, North KE, Avery CL, Graff M, Haiman CA, Le Marchand L, Wilkens LR, Bis JC, Leonard H, Shen B, Lange LA, Giri A, Dikilitas O, Kullo IJ, Stanaway IB, Jarvik GP, Gordon AS, Hebbring S, Namjou B, Kaufman KM, Ito K, Ishigaki K, Kamatani Y, Verma SS, Ritchie MD, Kember RL, Baras A, Lotta LA, , , , , Kathiresan S, Hauser ER, Miller DR, Lee JS, Saleheen D, Reaven PD, Cho K, Gaziano JM, Natarajan P, Huffman JE, Voight BF, Rader DJ, Chang KM, Lynch JA, Damrauer SM, Wilson PWF, Tang H, Sun YV, Tsao PS, O'Donnell CJ, Assimes TL. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med [print-electronic]. 2022 Aug; 28(8): 1679-92. PMID: 35915156, PMCID: PMC9419655, PII: 10.1038/s41591-022-01891-3, DOI: 10.1038/s41591-022-01891-3, ISSN: 1546-170X.

Lamberg M, Rossman A, Bennett A, Painter S, Goodman R, MacLeod J, Maddula R, Rayan D, Doshi K, Bick A, Bailey S, Brown SA. Next Generation Risk Markers in Preventive Cardio-oncology. Curr Atheroscler Rep [print-electronic]. 2022 Jun; 24(6): 443-56. PMID: 35441347, PMCID: PMC10026729, PII: 10.1007/s11883-022-01021-x, DOI: 10.1007/s11883-022-01021-x, ISSN: 1534-6242.

Uddin MM, Zhou Y, Bick AG, Burugula BB, Jaiswal S, Desai P, Honigberg MC, Love SA, Barac A, Hayden KM, Manson JE, Whitsel EA, Kooperberg C, Natarajan P, Reiner AP, Kitzman JO. Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics. Immun Ageing. 2022 May 5/24/2022; 19(1): 23. PMID: 35610705, PMCID: PMC9128083, PII: 10.1186/s12979-022-00278-9, DOI: 10.1186/s12979-022-00278-9, ISSN: 1742-4933.

Levin MG, Nakao T, Zekavat SM, Koyama S, Bick AG, Niroula A, Ebert B, Damrauer SM, Natarajan P. Genetics of smoking and risk of clonal hematopoiesis. Sci Rep. 2022 May 5/4/2022; 12(1): 7248. PMID: 35508625, PMCID: PMC9068754, PII: 10.1038/s41598-022-09604-z, DOI: 10.1038/s41598-022-09604-z, ISSN: 2045-2322.

Amancherla K, Wells JA, Bick AG. Clonal hematopoiesis and vascular disease. Semin Immunopathol [print-electronic]. 2022 May; 44(3): 303-8. PMID: 35122117, PMCID: PMC9064918, PII: 10.1007/s00281-022-00913-z, DOI: 10.1007/s00281-022-00913-z, ISSN: 1863-2300.

Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, Niroula A, Carty CL, Lane J, Honigberg MC, Weinstock JS, Pampana A, Gibson CJ, Griffin GK, Clarke SL, Bhattacharya R, Assimes TL, Emery LS, Stilp AM, Wong Q, Broome J, Laurie CA, Khan AT, Smith AV, Blackwell TW, Codd V, Nelson CP, Yoneda ZT, Peralta JM, Bowden DW, Irvin MR, Boorgula M, Zhao W, Yanek LR, Wiggins KL, Hixson JE, Gu CC, Peloso GM, Roden DM, Reupena MS, Hwu CM, DeMeo DL, North KE, Kelly S, Musani SK, Bis JC, Lloyd-Jones DM, Johnsen JM, Preuss M, Tracy RP, Peyser PA, Qiao D, Desai P, Curran JE, Freedman BI, Tiwari HK, Chavan S, Smith JA, Smith NL, Kelly TN, Hidalgo B, Cupples LA, Weeks DE, Hawley NL, Minster RL, , Deka R, Naseri TT, de Las Fuentes L, Raffield LM, Morrison AC, Vries PS, Ballantyne CM, Kenny EE, Rich SS, Whitsel EA, Cho MH, Shoemaker MB, Pace BS, Blangero J, Palmer ND, Mitchell BD, Shuldiner AR, Barnes KC, Redline S, Kardia SLR, Abecasis GR, Becker LC, Heckbert SR, He J, Post W, Arnett DK, Vasan RS, Darbar D, Weiss ST, McGarvey ST, de Andrade M, Chen YI, Kaplan RC, Meyers DA, Custer BS, Correa A, Psaty BM, Fornage M, Manson JE, Boerwinkle E, Konkle BA, Loos RJF, Rotter JI, Silverman EK, Kooperberg C, Danesh J, Samani NJ, Jaiswal S, Libby P, Ellinor PT, Pankratz N, Ebert BL, Reiner AP, Mathias RA, Do R, , Natarajan P. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Sci Adv [print-electronic]. 2022 Apr 4/8/2022; 8(14): eabl6579. PMID: 35385311, PMCID: PMC8986098, DOI: 10.1126/sciadv.abl6579, ISSN: 2375-2548.

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Bick AG, Popadin K, Thorball CW, Uddin MM, Zanni MV, Yu B, Cavassini M, Rauch A, Tarr P, Schmid P, Bernasconi E, Günthard HF, Libby P, Boerwinkle E, McLaren PJ, Ballantyne CM, Grinspoon S, Natarajan P, Fellay J, . Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV. Sci Rep. 2022 Jan 1/12/2022; 12(1): 577. PMID: 35022435, PMCID: PMC8755790, PII: 10.1038/s41598-021-04308-2, DOI: 10.1038/s41598-021-04308-2, ISSN: 2045-2322.

Heimlich JB, Bick AG. Somatic Mutations in Cardiovascular Disease. Circ Res [print-electronic]. 2022 Jan 1/7/2022; 130(1): 149-61. PMID: 34995138, PMCID: PMC8827644, DOI: 10.1161/CIRCRESAHA.121.319809, ISSN: 1524-4571.

Walsh K, Raghavachari N, Kerr C, Bick AG, Cummings SR, Druley T, Dunbar CE, Genovese G, Goodell MA, Jaiswal S, Maciejewski J, Natarajan P, Shindyapina AV, Shuldiner AR, Van Den Akker EB, Vijg J. Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans. Front Aging. 2022; 3: 841796. PMID: 35821803, PMCID: PMC9261374, PII: 841796, DOI: 10.3389/fragi.2022.841796, ISSN: 2673-6217.

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Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med [print-electronic]. 2021 Dec 12/6/2021; 218(12): PMID: 34698806, PMCID: PMC8552148, PII: 212724, DOI: 10.1084/jem.20211872, ISSN: 1540-9538.

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Niroula A, Sekar A, Murakami MA, Trinder M, Agrawal M, Wong WJ, Bick AG, Uddin MM, Gibson CJ, Griffin GK, Honigberg MC, Zekavat SM, Paruchuri K, Natarajan P, Ebert BL. Distinction of lymphoid and myeloid clonal hematopoiesis. Nat Med [print-electronic]. 2021 Nov; 27(11): 1921-7. PMID: 34663986, PMCID: PMC8621497, PII: 10.1038/s41591-021-01521-4, DOI: 10.1038/s41591-021-01521-4, ISSN: 1546-170X.

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Bhattacharya R, Zekavat SM, Uddin MM, Pirruccello J, Niroula A, Gibson C, Griffin GK, Libby P, Ebert BL, Bick A, Natarajan P. Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events. JAMA Cardiol [print-electronic]. 2021 Jun 6/9/2021; PMID: 34106216, PMCID: PMC8190703, PII: 2780386, DOI: 10.1001/jamacardio.2021.1678, ISSN: 2380-6591.

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Bao EL, Nandakumar SK, Liao X, Bick AG, Karjalainen J, Tabaka M, Gan OI, Havulinna AS, Kiiskinen TTJ, Lareau CA, de Lapuente Portilla AL, Li B, Emdin C, Codd V, Nelson CP, Walker CJ, Churchhouse C, de la Chapelle A, Klein DE, Nilsson B, Wilson PWF, Cho K, Pyarajan S, Gaziano JM, Samani NJ, , , Regev A, Palotie A, Neale BM, Dick JE, Natarajan P, O'Donnell CJ, Daly MJ, Milyavsky M, Kathiresan S, Sankaran VG. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature [print-electronic]. 2020 Oct 10/14/2020; PMID: 33057200, PII: 10.1038/s41586-020-2786-7, DOI: 10.1038/s41586-020-2786-7, ISSN: 1476-4687.

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Katz DH, Tahir UA, Ngo D, Benson MD, Bick AG, Pampana A, Gao Y, Keyes MJ, Correa A, Sinha S, Shen D, Yang Q, Robbins JM, Chen ZZ, Cruz DE, Peterson B, Natarajan P, Vasan RS, Smith G, Wang TJ, Gerszten RE. Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19. MedRxiv. 2020 Jun 6/11/2020; PMID: 32577670, PMCID: PMC7302224, DOI: 10.1101/2020.06.09.20125690.

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Pirruccello JP, Bick A, Chaffin M, Aragam KG, Choi SH, Lubitz SA, Ho CY, Ng K, Philippakis A, Ellinor PT, Kathiresan S, Khera AV. Titin Truncating Variants in Adults Without Known Congestive Heart Failure [letter]. J. Am. Coll. Cardiol. 2020 Mar 3/17/2020; 75(10): 1239-41. PMID: 32164899, PII: S0735-1097(20)30193-5, DOI: 10.1016/j.jacc.2020.01.013, ISSN: 1558-3597.

Bick AG, Pirruccello JP, Griffin GK, Gupta N, Gabriel S, Saleheen D, Libby P, Kathiresan S, Natarajan P. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Circulation [print-electronic]. 2020 Jan 1/14/2020; 141(2): 124-31. PMID: 31707836, PMCID: PMC7008855, DOI: 10.1161/CIRCULATIONAHA.119.044362, ISSN: 1524-4539.

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Emdin CA, Khera AV, Chaffin M, Klarin D, Natarajan P, Aragam K, Haas M, Bick A, Zekavat SM, Nomura A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Chasman D, Ridker P, Denny J, Bastarache L, Lichtman JH, D'Onofrio G, Mattera J, Spertus JA, Sheu WH, Taylor KD, Psaty BM, Rich SS, Post W, Rotter JI, Chen YI, Krumholz H, Saleheen D, Gabriel S, Kathiresan S. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun. 2018 Apr 4/24/2018; 9(1): 1613. PMID: 29691411, PMCID: PMC5915445, PII: 10.1038/s41467-018-03911-8, DOI: 10.1038/s41467-018-03911-8, ISSN: 2041-1723.

Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR. UBD modifies APOL1-induced kidney disease risk. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Mar 3/27/2018; 115(13): 3446-51. PMID: 29531077, PMCID: PMC5879665, PII: 1716113115, DOI: 10.1073/pnas.1716113115, ISSN: 1091-6490.

Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Oct 10/24/2017; 114(43): E9096-E9104. PMID: 29073106, PMCID: PMC5664535, PII: 1711303114, DOI: 10.1073/pnas.1711303114, ISSN: 1091-6490.

Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S, Ebert BL. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N. Engl. J. Med [print-electronic]. 2017 Jul 7/13/2017; 377(2): 111-21. PMID: 28636844, PMCID: PMC6717509, DOI: 10.1056/NEJMoa1701719, ISSN: 1533-4406.

Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E. Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. PLoS ONE. 2017; 12(3): e0172995. PMID: 28296976, PMCID: PMC5351854, PII: PONE-D-16-39590, DOI: 10.1371/journal.pone.0172995, ISSN: 1932-6203.

Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S, , . Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J. Am. Coll. Cardiol. 2016 Dec 12/27/2016; 68(25): 2761-72. PMID: 28007139, PMCID: PMC5328146, PII: S0735-1097(16)36781-X, DOI: 10.1016/j.jacc.2016.10.033, ISSN: 1558-3597.

Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N. Engl. J. Med [print-electronic]. 2016 Dec 12/15/2016; 375(24): 2349-58. PMID: 27959714, PMCID: PMC5338864, DOI: 10.1056/NEJMoa1605086, ISSN: 1533-4406.

DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev. Cell [print-electronic]. 2016 Nov 11/21/2016; 39(4): 480-90. PMID: 27840107, PMCID: PMC5198784, PII: S1534-5807(16)30682-7, DOI: 10.1016/j.devcel.2016.10.001, ISSN: 1878-1551.

Natarajan P, Gold NB, Bick AG, McLaughlin H, Kraft P, Rehm HL, Peloso GM, Wilson JG, Correa A, Seidman JG, Seidman CE, Kathiresan S, Green RC. Aggregate penetrance of genomic variants for actionable disorders in European and African Americans. Sci Transl Med. 2016 Nov 11/9/2016; 8(364): 364ra151. PMID: 27831900, PMCID: PMC5823271, PII: 8/364/364ra151, DOI: 10.1126/scitranslmed.aag2367, ISSN: 1946-6242.

Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J. Am. Coll. Cardiol [print-electronic]. 2016 Jun 6/7/2016; 67(22): 2578-89. PMID: 27050191, PMCID: PMC5405769, PII: S0735-1097(16)32399-3, DOI: 10.1016/j.jacc.2016.03.520, ISSN: 1558-3597.

Roberts AM, Ware JS, Herman DS, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, Flannick J, Gabriel SB, Altshuler DM, Macdonald PS, Heinig M, Keogh AM, Hayward CS, Banner NR, Pennell DJ, O'Regan DP, San TR, de Marvao A, Dawes TJ, Gulati A, Birks EJ, Yacoub MH, Radke M, Gotthardt M, Wilson JG, O'Donnell CJ, Prasad SK, Barton PJ, Fatkin D, Hubner N, Seidman JG, Seidman CE, Cook SA. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med. 2015 Jan 1/14/2015; 7(270): 270ra6. PMID: 25589632, PMCID: PMC4560092, PII: 7/270/270ra6, DOI: 10.1126/scitranslmed.3010134, ISSN: 1946-6242.

Naik RP, Derebail VK, Grams ME, Franceschini N, Auer PL, Peloso GM, Young BA, Lettre G, Peralta CA, Katz R, Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P, Rich SS, Smith JD, Boerwinkle E, Rosamond WD, Ito K, Lanzkron S, Coresh J, Correa A, Sarto GE, Key NS, Jacobs DR, Kathiresan S, Bibbins-Domingo K, Kshirsagar AV, Wilson JG, Reiner AP. Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. JAMA. 2014 Nov 11/26/2014; 312(20): 2115-25. PMID: 25393378, PMCID: PMC4356116, PII: 1935577, DOI: 10.1001/jama.2014.15063, ISSN: 1538-3598.

Glessner JT, Bick AG, Ito K, Homsy J, Rodriguez-Murillo L, Fromer M, Mazaika E, Vardarajan B, Italia M, Leipzig J, DePalma SR, Golhar R, Sanders SJ, Yamrom B, Ronemus M, Iossifov I, Willsey AJ, State MW, Kaltman JR, White PS, Shen Y, Warburton D, Brueckner M, Seidman C, Goldmuntz E, Gelb BD, Lifton R, Seidman J, Hakonarson H, Chung WK. Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data. Circ. Res [print-electronic]. 2014 Oct 10/24/2014; 115(10): 884-96. PMID: 25205790, PMCID: PMC4209190, DOI: 10.1161/CIRCRESAHA.115.304458, ISSN: 1524-4571.

Fahed AC, McDonough B, Gouvion CM, Newell KL, Dure LS, Bebin M, Bick AG, Seidman JG, Harter DH, Seidman CE. UBQLN2 mutation causing heterogeneous X-linked dominant neurodegeneration. Ann. Neurol [print-electronic]. 2014 May; 75(5): 793-8. PMID: 24771548, PMCID: PMC4106259, DOI: 10.1002/ana.24164, ISSN: 1531-8249.

Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, Pollak MR, Wilson JG, Seidman JG, Seidman C. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ. Res [print-electronic]. 2014 Feb 2/28/2014; 114(5): 845-50. PMID: 24379297, PMCID: PMC3982584, PII: CIRCRESAHA.114.302347, DOI: 10.1161/CIRCRESAHA.114.302347, ISSN: 1524-4571.

Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, Brosnan MJ, Trimmer JK, Newton-Cheh C, Tuomi T, Molven A, Wilson JG, O'Donnell CJ, Kathiresan S, Hirschhorn JN, Njølstad PR, Rolph T, Seidman JG, Gabriel S, Cox DR, Seidman CE, Groop L, Altshuler D. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat. Genet [print-electronic]. 2013 Nov; 45(11): 1380-5. PMID: 24097065, PMCID: PMC4051627, PII: ng.2794, DOI: 10.1038/ng.2794, ISSN: 1546-1718.

Bick AG, Flannick J, Ito K, Cheng S, Vasan RS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, O'Donnell CJ, Wilson JG, Altshuler DM, Hirschhorn JN, Seidman JG, Seidman C. Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am. J. Hum. Genet. 2012 Sep 9/7/2012; 91(3): 513-9. PMID: 22958901, PMCID: PMC3511985, PII: S0002-9297(12)00374-6, DOI: 10.1016/j.ajhg.2012.07.017, ISSN: 1537-6605.

Bick AG, Calvo SE, Mootha VK. Evolutionary diversity of the mitochondrial calcium uniporter. Science. 2012 May 5/18/2012; 336(6083): 886. PMID: 22605770, PMCID: PMC3518847, PII: 336/6083/886, DOI: 10.1126/science.1214977, ISSN: 1095-9203.

Wheeldon I, Farhadi A, Bick AG, Jabbari E, Khademhosseini A. Nanoscale tissue engineering: spatial control over cell-materials interactions. Nanotechnology [print-electronic]. 2011 May 5/27/2011; 22(21): 212001. PMID: 21451238, PMCID: PMC3155808, PII: S0957-4484(11)67179-1, DOI: 10.1088/0957-4484/22/21/212001, ISSN: 1361-6528.