Alexander Bick, Ph.D., M.D.

Assistant Professor

Faculty Appointments
Assistant Professor of Medicine
M.D., Harvard University, Cambridge, MassachusettsPh.D., Genetics, Harvard University, Cambridge, MassachusettsS.B., Engineering Sciences, Harvard University, Cambridge, MassachusettsS.M., Engineering and Applied Science, Harvard University, Cambridge, Massachusetts
Research Description
Dr. Bick is a physician-scientist working in the field of human genomics. His scientific observations have advanced our understanding of the genetic basis for cardiovascular disease, characterized molecular disease mechanisms and identified both the promise and limitations of translating genomic findings into routine medical practice. He has a particular interest in understanding how the interplay between inherited germline genetic factors and acquired somatic mutations contributes to disease. His approach has been highly collaborative and multidisciplinary – combining human genomics and statistical genetics with in-vitro and in-vivo characterization of model systems and human samples.

Dr Bick’s current scientific focus is on clonal hematopoiesis, a unifying feature of aging diseases as diverse as cardiovascular disease and cancer. He has recently demonstrated that clonal hematopoiesis is virtually absent in adults under 40, but found in >10% of adults over 70 and confers a 10-fold increased risk of blood cancers, 2-fold increased risk of heart attack and 1.5-fold increased risk of death. Dr. Bick is focused on identifying the causes and consequences of clonal hematopoiesis with a goal of developing new treatments targeting clonal hematopoiesis.
Clinical Description
In parallel with his research, Dr. Bick completed clinical training in Internal Medicine at Massachusetts General Hospital with a specialization in genomic medicine. He looks forward to seeing patients in the Vanderbilt Genomics and Therapeutics Clinic and aims to translate what is learned from his research studies back to the care of his patients.
Research Keywords
Human Genetics, Clonal Hematopoiesis, Cardiovascular disease,
Clinical Research Keywords
Preventative Genomic Medicine, Clonal Hematopoiesis of Indeterminate Potential (CHIP), Polygenic risk scores
Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD, , Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S, Natarajan P. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature [print-electronic]. 2020 Oct 10/14/2020; PMID: 33057201, PII: 10.1038/s41586-020-2819-2, DOI: 10.1038/s41586-020-2819-2, ISSN: 1476-4687.

Bao EL, Nandakumar SK, Liao X, Bick AG, Karjalainen J, Tabaka M, Gan OI, Havulinna AS, Kiiskinen TTJ, Lareau CA, de Lapuente Portilla AL, Li B, Emdin C, Codd V, Nelson CP, Walker CJ, Churchhouse C, de la Chapelle A, Klein DE, Nilsson B, Wilson PWF, Cho K, Pyarajan S, Gaziano JM, Samani NJ, , , Regev A, Palotie A, Neale BM, Dick JE, Natarajan P, O'Donnell CJ, Daly MJ, Milyavsky M, Kathiresan S, Sankaran VG. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature [print-electronic]. 2020 Oct 10/14/2020; PMID: 33057200, PII: 10.1038/s41586-020-2786-7, DOI: 10.1038/s41586-020-2786-7, ISSN: 1476-4687.

Fahed AC, Wang M, Homburger JR, Patel AP, Bick AG, Neben CL, Lai C, Brockman D, Philippakis A, Ellinor PT, Cassa CA, Lebo M, Ng K, Lander ES, Zhou AY, Kathiresan S, Khera AV. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Nat Commun. 2020 Aug 8/20/2020; 11(1): 3635. PMID: 32820175, PMCID: PMC7441381, PII: 10.1038/s41467-020-17374-3, DOI: 10.1038/s41467-020-17374-3, ISSN: 2041-1723.

Katz DH, Tahir UA, Ngo D, Benson MD, Bick AG, Pampana A, Gao Y, Keyes MJ, Correa A, Sinha S, Shen D, Yang Q, Robbins JM, Chen ZZ, Cruz DE, Peterson B, Natarajan P, Vasan RS, Smith G, Wang TJ, Gerszten RE. Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19. MedRxiv. 2020 Jun 6/11/2020; PMID: 32577670, PMCID: PMC7302224, DOI: 10.1101/2020.06.09.20125690.

Pirruccello JP, Bick A, Wang M, Chaffin M, Friedman S, Yao J, Guo X, Venkatesh BA, Taylor KD, Post WS, Rich S, Lima JAC, Rotter JI, Philippakis A, Lubitz SA, Ellinor PT, Khera AV, Kathiresan S, Aragam KG. Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy. Nat Commun. 2020 May 5/7/2020; 11(1): 2254. PMID: 32382064, PMCID: PMC7206184, PII: 10.1038/s41467-020-15823-7, DOI: 10.1038/s41467-020-15823-7, ISSN: 2041-1723.

Magudia K, Ng TSC, Bick AG, Koster MA, Bay C, Rexrode KM, Smith SE, Weinstein DF. Parenting While in Training: A Comprehensive Needs Assessment of Residents and Fellows. J Grad Med Educ. 2020 Apr; 12(2): 162-7. PMID: 32322349, PMCID: PMC7161335, PII: Customer: JGME-D-19-00563, DOI: 10.4300/JGME-D-19-00563.1, ISSN: 1949-8357.

Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, Hindy G, Jiang L, Wei WQ, Feng Q, Karjalainen J, Havulinna A, Kiiskinen T, Bick A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Saleheen D, Chang KM, Vujkovic M, Voight B, Damrauer S, Lynch J, Kaplan D, Serper M, Tsao P, , Mercader J, Hanis C, Daly M, Denny J, Gabriel S, Kathiresan S. A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genet. 2020 Apr; 16(4): e1008629. PMID: 32282858, PMCID: PMC7200007, PII: PGENETICS-D-19-01644, DOI: 10.1371/journal.pgen.1008629, ISSN: 1553-7404.

Pirruccello JP, Bick A, Chaffin M, Aragam KG, Choi SH, Lubitz SA, Ho CY, Ng K, Philippakis A, Ellinor PT, Kathiresan S, Khera AV. Titin Truncating Variants in Adults Without Known Congestive Heart Failure [letter]. J. Am. Coll. Cardiol. 2020 Mar 3/17/2020; 75(10): 1239-41. PMID: 32164899, PII: S0735-1097(20)30193-5, DOI: 10.1016/j.jacc.2020.01.013, ISSN: 1558-3597.

Bick AG, Pirruccello JP, Griffin GK, Gupta N, Gabriel S, Saleheen D, Libby P, Kathiresan S, Natarajan P. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Circulation [print-electronic]. 2020 Jan 1/14/2020; 141(2): 124-31. PMID: 31707836, PMCID: PMC7008855, DOI: 10.1161/CIRCULATIONAHA.119.044362, ISSN: 1524-4539.

Bick AG, Akwo E, Robinson-Cohen C, Lee K, Lynch J, Assimes TL, DuVall S, Edwards T, Fang H, Freiberg SM, Giri A, Huffman JE, Huang J, Hull L, Kember RL, Klarin D, Lee JS, Levin M, Miller DR, Natarajan P, Saleheen D, Shao Q, Sun YV, Tang H, Wilson O, Chang KM, Cho K, Concato J, Gaziano JM, Kathiresan S, O'Donnell CJ, Rader DJ, Tsao PS, Wilson PW, Hung AM, Damrauer SM, . Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Circulation [print-electronic]. 2019 Sep 9/17/2019; 140(12): 1031-40. PMID: 31337231, PMCID: PMC6754626, DOI: 10.1161/CIRCULATIONAHA.118.036589, ISSN: 1524-4539.

Khetarpal SA, Qamar A, Bick AG, Fuster JJ, Kathiresan S, Jaiswal S, Natarajan P. Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. J. Am. Coll. Cardiol. 2019 Jul 7/30/2019; 74(4): 578-86. PMID: 31345433, PMCID: PMC6662618, PII: S0735-1097(19)35380-X, DOI: 10.1016/j.jacc.2019.05.045, ISSN: 1558-3597.

Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, Distefano M, Senol-Cosar O, Haas ME, Bick A, Aragam KG, Lander ES, Smith GD, Mason-Suares H, Fornage M, Lebo M, Timpson NJ, Kaplan LM, Kathiresan S. Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood. Cell. 2019 Apr 4/18/2019; 177(3): 587-596.e9. PMID: 31002795, PMCID: PMC6661115, PII: S0092-8674(19)30290-9, DOI: 10.1016/j.cell.2019.03.028, ISSN: 1097-4172.

Emdin CA, Khera AV, Aragam K, Haas M, Chaffin M, Klarin D, Natarajan P, Bick A, Zekavat SM, Nomura A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Saleheen D, Gabriel S, Kathiresan S. DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes. Diabetes [print-electronic]. 2019 Jan; 68(1): 226-34. PMID: 30389748, PMCID: PMC6302541, PII: db18-0857, DOI: 10.2337/db18-0857, ISSN: 1939-327X.

Haas ME, Aragam KG, Emdin CA, Bick AG, , Hemani G, Davey Smith G, Kathiresan S. Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. Am. J. Hum. Genet [print-electronic]. 2018 Oct 10/4/2018; 103(4): 461-73. PMID: 30220432, PMCID: PMC6174360, PII: S0002-9297(18)30270-2, DOI: 10.1016/j.ajhg.2018.08.004, ISSN: 1537-6605.

Emdin CA, Khera AV, Chaffin M, Klarin D, Natarajan P, Aragam K, Haas M, Bick A, Zekavat SM, Nomura A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Chasman D, Ridker P, Denny J, Bastarache L, Lichtman JH, D'Onofrio G, Mattera J, Spertus JA, Sheu WH, Taylor KD, Psaty BM, Rich SS, Post W, Rotter JI, Chen YI, Krumholz H, Saleheen D, Gabriel S, Kathiresan S. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun. 2018 Apr 4/24/2018; 9(1): 1613. PMID: 29691411, PMCID: PMC5915445, PII: 10.1038/s41467-018-03911-8, DOI: 10.1038/s41467-018-03911-8, ISSN: 2041-1723.

Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR. UBD modifies APOL1-induced kidney disease risk. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Mar 3/27/2018; 115(13): 3446-51. PMID: 29531077, PMCID: PMC5879665, PII: 1716113115, DOI: 10.1073/pnas.1716113115, ISSN: 1091-6490.

Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Oct 10/24/2017; 114(43): E9096-E9104. PMID: 29073106, PMCID: PMC5664535, PII: 1711303114, DOI: 10.1073/pnas.1711303114, ISSN: 1091-6490.

Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S, Ebert BL. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N. Engl. J. Med [print-electronic]. 2017 Jul 7/13/2017; 377(2): 111-21. PMID: 28636844, PMCID: PMC6717509, DOI: 10.1056/NEJMoa1701719, ISSN: 1533-4406.

Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E. Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. PLoS ONE. 2017; 12(3): e0172995. PMID: 28296976, PMCID: PMC5351854, PII: PONE-D-16-39590, DOI: 10.1371/journal.pone.0172995, ISSN: 1932-6203.

Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S, , . Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J. Am. Coll. Cardiol. 2016 Dec 12/27/2016; 68(25): 2761-72. PMID: 28007139, PMCID: PMC5328146, PII: S0735-1097(16)36781-X, DOI: 10.1016/j.jacc.2016.10.033, ISSN: 1558-3597.

Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N. Engl. J. Med [print-electronic]. 2016 Dec 12/15/2016; 375(24): 2349-58. PMID: 27959714, PMCID: PMC5338864, DOI: 10.1056/NEJMoa1605086, ISSN: 1533-4406.

DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev. Cell [print-electronic]. 2016 Nov 11/21/2016; 39(4): 480-90. PMID: 27840107, PMCID: PMC5198784, PII: S1534-5807(16)30682-7, DOI: 10.1016/j.devcel.2016.10.001, ISSN: 1878-1551.

Natarajan P, Gold NB, Bick AG, McLaughlin H, Kraft P, Rehm HL, Peloso GM, Wilson JG, Correa A, Seidman JG, Seidman CE, Kathiresan S, Green RC. Aggregate penetrance of genomic variants for actionable disorders in European and African Americans. Sci Transl Med. 2016 Nov 11/9/2016; 8(364): 364ra151. PMID: 27831900, PMCID: PMC5823271, PII: 8/364/364ra151, DOI: 10.1126/scitranslmed.aag2367, ISSN: 1946-6242.

Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J. Am. Coll. Cardiol [print-electronic]. 2016 Jun 6/7/2016; 67(22): 2578-89. PMID: 27050191, PMCID: PMC5405769, PII: S0735-1097(16)32399-3, DOI: 10.1016/j.jacc.2016.03.520, ISSN: 1558-3597.

Roberts AM, Ware JS, Herman DS, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, Flannick J, Gabriel SB, Altshuler DM, Macdonald PS, Heinig M, Keogh AM, Hayward CS, Banner NR, Pennell DJ, O'Regan DP, San TR, de Marvao A, Dawes TJ, Gulati A, Birks EJ, Yacoub MH, Radke M, Gotthardt M, Wilson JG, O'Donnell CJ, Prasad SK, Barton PJ, Fatkin D, Hubner N, Seidman JG, Seidman CE, Cook SA. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med. 2015 Jan 1/14/2015; 7(270): 270ra6. PMID: 25589632, PMCID: PMC4560092, PII: 7/270/270ra6, DOI: 10.1126/scitranslmed.3010134, ISSN: 1946-6242.

Naik RP, Derebail VK, Grams ME, Franceschini N, Auer PL, Peloso GM, Young BA, Lettre G, Peralta CA, Katz R, Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P, Rich SS, Smith JD, Boerwinkle E, Rosamond WD, Ito K, Lanzkron S, Coresh J, Correa A, Sarto GE, Key NS, Jacobs DR, Kathiresan S, Bibbins-Domingo K, Kshirsagar AV, Wilson JG, Reiner AP. Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. JAMA. 2014 Nov 11/26/2014; 312(20): 2115-25. PMID: 25393378, PMCID: PMC4356116, PII: 1935577, DOI: 10.1001/jama.2014.15063, ISSN: 1538-3598.

Glessner JT, Bick AG, Ito K, Homsy J, Rodriguez-Murillo L, Fromer M, Mazaika E, Vardarajan B, Italia M, Leipzig J, DePalma SR, Golhar R, Sanders SJ, Yamrom B, Ronemus M, Iossifov I, Willsey AJ, State MW, Kaltman JR, White PS, Shen Y, Warburton D, Brueckner M, Seidman C, Goldmuntz E, Gelb BD, Lifton R, Seidman J, Hakonarson H, Chung WK. Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data. Circ. Res [print-electronic]. 2014 Oct 10/24/2014; 115(10): 884-96. PMID: 25205790, PMCID: PMC4209190, DOI: 10.1161/CIRCRESAHA.115.304458, ISSN: 1524-4571.

Fahed AC, McDonough B, Gouvion CM, Newell KL, Dure LS, Bebin M, Bick AG, Seidman JG, Harter DH, Seidman CE. UBQLN2 mutation causing heterogeneous X-linked dominant neurodegeneration. Ann. Neurol [print-electronic]. 2014 May; 75(5): 793-8. PMID: 24771548, PMCID: PMC4106259, DOI: 10.1002/ana.24164, ISSN: 1531-8249.

Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, Pollak MR, Wilson JG, Seidman JG, Seidman C. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ. Res [print-electronic]. 2014 Feb 2/28/2014; 114(5): 845-50. PMID: 24379297, PMCID: PMC3982584, PII: CIRCRESAHA.114.302347, DOI: 10.1161/CIRCRESAHA.114.302347, ISSN: 1524-4571.

Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, Brosnan MJ, Trimmer JK, Newton-Cheh C, Tuomi T, Molven A, Wilson JG, O'Donnell CJ, Kathiresan S, Hirschhorn JN, Njølstad PR, Rolph T, Seidman JG, Gabriel S, Cox DR, Seidman CE, Groop L, Altshuler D. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat. Genet [print-electronic]. 2013 Nov; 45(11): 1380-5. PMID: 24097065, PMCID: PMC4051627, PII: ng.2794, DOI: 10.1038/ng.2794, ISSN: 1546-1718.

Bick AG, Flannick J, Ito K, Cheng S, Vasan RS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, O'Donnell CJ, Wilson JG, Altshuler DM, Hirschhorn JN, Seidman JG, Seidman C. Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am. J. Hum. Genet. 2012 Sep 9/7/2012; 91(3): 513-9. PMID: 22958901, PMCID: PMC3511985, PII: S0002-9297(12)00374-6, DOI: 10.1016/j.ajhg.2012.07.017, ISSN: 1537-6605.

Bick AG, Calvo SE, Mootha VK. Evolutionary diversity of the mitochondrial calcium uniporter. Science. 2012 May 5/18/2012; 336(6083): 886. PMID: 22605770, PMCID: PMC3518847, PII: 336/6083/886, DOI: 10.1126/science.1214977, ISSN: 1095-9203.

Wheeldon I, Farhadi A, Bick AG, Jabbari E, Khademhosseini A. Nanoscale tissue engineering: spatial control over cell-materials interactions. Nanotechnology [print-electronic]. 2011 May 5/27/2011; 22(21): 212001. PMID: 21451238, PMCID: PMC3155808, PII: S0957-4484(11)67179-1, DOI: 10.1088/0957-4484/22/21/212001, ISSN: 1361-6528.