Faculty Appointments
Professor of Medicine
Education
M.Sc., Clinical Research, Emory University School of Medicine, Atlanta, GeorgiaB.Sc., Biology, James Madison University, Harrisonburg, Virginia
Office Address
1215 21st Avenue S, MCE 5th Floor North Tower
Nashville, TN 37232
Nashville, TN 37232
Research Description
I am a translational researcher leveraging my expertise in cohort development, clinical cardiology, cardiovascular epidemiology, and acute myocardial infarction (MI) to better understand, diagnose, and predict the full spectrum of myocardial injury events, specifically subtypes of MI. I am a board-certified Cardiologist and Associate Professor of Medicine in the Division of Cardiovascular Medicine at Vanderbilt University, and an Adjunct Professor at Johns Hopkins University. I am the Medical Director of the Cardiovascular Intensive Care Unit. I have significant experience evaluating cardiovascular risk prediction in the Multi-Ethnic Study of Atherosclerosis (MESA) and serve on the MESA Project & Publication Committee. I also have significant experience in acute MI diagnosis, treatment, and research. I serve on the steering committee for the NIH-sponsored, multicenter Myocardial Ischemia and Transfusion (MINT) trial and lead the highest enrolling center in the United States for this trial. I adjudicated over 800 cases for presence of acute MI as part of a diagnostic point of care troponin assay seeking FDA approval. My work has been published in multiple peer-reviewed journals, including Annals of Internal Medicine, The Lancet, and Journal of the American College of Cardiology. An invited Viewpoint from Circulation Research, “Myocardial Infarction as a Clinical Endpoint in Research—What Are We Really Talking About?” was published with my co-PI, Khurram Nasir, and Co-I, Michael Blaha, in June of 2019. An invited White Paper for Circulation, “Assessment and Treatment of Patients with Type 2 Myocardial Infarction and Acute Non-Ischemic Myocardial Injury” was published in November of 2019.
Clinical Description
I am a board-certified Cardiologist and Associate Professor of Medicine in the Division of Cardiovascular Medicine at Vanderbilt University, and an Adjunct Professor at Johns Hopkins University. I am the Medical Director of the Cardiovascular Intensive Care Unit.
Research Keywords
myocardial injury, myocardial infarction, atherothrombotic, thrombosis, omics, critical care cardiology, biomarkers, proteomics, metabolomics
Publications
Blaha MJ, Naazie IN, Cainzos-Achirica M, Dardari ZA, DeFilippis AP, McClelland RL, Mirbolouk M, Orimoloye OA, Dzaye O, Nasir K, Page JH. Derivation of a Coronary Age Calculator Using Traditional Risk Factors and Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc [print-electronic]. 2021 Mar 3/16/2021; 10(6): e019351. PMID: 33663219, DOI: 10.1161/JAHA.120.019351, ISSN: 2047-9980.
Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis AP, Rai SN, Bhatnagar A. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol [print-electronic]. 2021 Mar 3/1/2021; 320(3): H1102-H1111. PMID: 33416460, DOI: 10.1152/ajpheart.00689.2020, ISSN: 1522-1539.
McGraw KE, Riggs DW, Rai S, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy S, Taylor KC, Conklin DJ, DeFilippis AP, Srivastava S, Bhatnagar A. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res [print-electronic]. 2021 Feb 2/24/2021; 196: 110903. PMID: 33636185, PII: S0013-9351(21)00197-3, DOI: 10.1016/j.envres.2021.110903, ISSN: 1096-0953.
Stokes AC, Xie W, Wilson AE, Yang H, Orimoloye OA, Harlow AF, Fetterman JL, DeFilippis AP, Benjamin EJ, Robertson RM, Bhatnagar A, Hamburg NM, Blaha MJ. Association of Cigarette and Electronic Cigarette Use Patterns With Levels of Inflammatory and Oxidative Stress Biomarkers Among US Adults: Population Assessment of Tobacco and Health Study [letter]. Circulation [print-electronic]. 2021 Feb 2/23/2021; 143(8): 869-71. PMID: 33390037, DOI: 10.1161/CIRCULATIONAHA.120.051551, ISSN: 1524-4539.
Irfan AB, Arab C, DeFilippis AP, Lorkiewicz P, Keith RJ, Xie Z, Bhatnagar A, Carll AP. Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine Release. Cardiovasc Toxicol [print-electronic]. 2021 Feb; 21(2): 169-78. PMID: 33043409, PMCID: PMC7855806, PII: 10.1007/s12012-020-09610-5, DOI: 10.1007/s12012-020-09610-5, ISSN: 1559-0259.
Singh A, Coulter AR, Trainor PJ, Singam NSV, Aladili BN, Amraotkar AR, Owolabi US, DeFilippis AP. Flow cytometric evaluation of platelet-leukocyte conjugate stability over time: methodological implications of sample handling and processing. J Thromb Thrombolysis. 2021 Jan; 51(1): 120-8. PMID: 32557223, PMCID: PMC7738362, PII: 10.1007/s11239-020-02186-5, DOI: 10.1007/s11239-020-02186-5, ISSN: 1573-742X.
O'Toole TE, Amraotkar AA, DeFilippis AP, Rai SN, Keith RJ, Baba SP, Lorkiewicz P, Crandell CE, Pariser GL, Wingard CJ, Pope Iii CA, Bhatnagar A. Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial. BMJ Open. 2020 Dec 12/28/2020; 10(12): e039118. PMID: 33372072, PMCID: PMC7772308, PII: bmjopen-2020-039118, DOI: 10.1136/bmjopen-2020-039118, ISSN: 2044-6055.
Chunawala Z, Chang PP, DeFilippis AP, Hall ME, Matsushita K, Caughey MC. Recurrent Admissions for Acute Decompensated Heart Failure Among Patients With and Without Peripheral Artery Disease: The ARIC Study. J Am Heart Assoc [print-electronic]. 2020 Nov 11/3/2020; 9(21): e017174. PMID: 33100106, PMCID: PMC7763414, DOI: 10.1161/JAHA.120.017174, ISSN: 2047-9980.
Uddin SMI, Osei AD, Obisesan OH, El-Shahawy O, Dzaye O, Cainzos-Achirica M, Mirbolouk M, Orimoloye OA, Stokes A, Benjamin EJ, Bhatnagar A, DeFilippis AP, Henry TS, Nasir K, Blaha MJ. Prevalence, Trends, and Distribution of Nicotine and Marijuana use in E-cigarettes among US adults: The Behavioral Risk Factor Surveillance System 2016-2018. Prev Med [print-electronic]. 2020 Oct; 139: 106175. PMID: 32593733, PII: S0091-7435(20)30199-7, DOI: 10.1016/j.ypmed.2020.106175, ISSN: 1096-0260.
Obisesan OH, Osei AD, Uddin SMI, Dzaye O, Cainzos-Achirica M, Mirbolouk M, Orimoloye OA, Sharma G, Al Rifai M, Stokes A, Bhatnagar A, El Shahawy O, Benjamin EJ, DeFilippis AP, Blaha MJ. E-Cigarette Use Patterns and High-Risk Behaviors in Pregnancy: Behavioral Risk Factor Surveillance System, 2016-2018. Am J Prev Med [print-electronic]. 2020 Aug; 59(2): 187-95. PMID: 32362509, PII: S0749-3797(20)30131-8, DOI: 10.1016/j.amepre.2020.02.015, ISSN: 1873-2607.
Sandoval Y, Bielinski SJ, Daniels LB, Blaha MJ, Michos ED, DeFilippis AP, Szklo M, deFilippi C, Larson NB, Decker PA, Jaffe AS. Atherosclerotic Cardiovascular Disease Risk Stratification Based on Measurements of Troponin and Coronary Artery Calcium. J Am Coll Cardiol. 2020 Jul 7/28/2020; 76(4): 357-70. PMID: 32703505, PMCID: PMC7513421, PII: S0735-1097(20)35511-X, DOI: 10.1016/j.jacc.2020.05.057, ISSN: 1558-3597.
Oshunbade AA, Yimer WK, Valle KA, Clark D, Kamimura D, White WB, DeFilippis AP, Blaha MJ, Benjamin EJ, O'Brien EC, Mentz RJ, Fox ER, O'Mara CS, Butler J, Correa A, Hall ME. Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study. J Am Heart Assoc [print-electronic]. 2020 Jun 6/16/2020; 9(12): e014990. PMID: 32517526, PMCID: PMC7429065, DOI: 10.1161/JAHA.119.014990, ISSN: 2047-9980.
van Diepen S, Tymchak W, Bohula EA, Park JG, Daniels LB, Phreaner N, Barnett CF, Kenigsberg BB, DeFilippis A, Singam NS, Barsness GW, Jentzer JC, Ternus B, Morrow DA, Katz JN, . Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry. Am Heart J [print-electronic]. 2020 Apr; 222: 8-14. PMID: 32006910, PII: S0002-8703(20)30019-3, DOI: 10.1016/j.ahj.2020.01.005, ISSN: 1097-6744.
Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MHEM, Zafar N, Krishnasamy S, DeFilippis A, Turner J, Rai SN, Bhatnagar A. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ [print-electronic]. 2020 Mar 3/10/2020; 707: 135435. PMID: 31865083, PMCID: PMC7294698, PII: S0048-9697(19)35428-2, DOI: 10.1016/j.scitotenv.2019.135435, ISSN: 1879-1026.
Centner CS, Murphy EM, Priddy MC, Moore JT, Janis BR, Menze MA, DeFilippis AP, Kopechek JA. Ultrasound-induced molecular delivery to erythrocytes using a microfluidic system. Biomicrofluidics. 2020 Mar; 14(2): 24114. PMID: 32341725, PMCID: PMC7176461, PII: 1.5144617, DOI: 10.1063/1.5144617, ISSN: 1932-1058.
Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Bhatnagar A, Biswal SS, Blaha MJ. Association Between E-Cigarette Use and Chronic Obstructive Pulmonary Disease by Smoking Status: Behavioral Risk Factor Surveillance System 2016 and 2017. Am J Prev Med [print-electronic]. 2020 Mar; 58(3): 336-42. PMID: 31902685, PII: S0749-3797(19)30479-9, DOI: 10.1016/j.amepre.2019.10.014, ISSN: 1873-2607.
Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res. 2020 Feb 2/6/2020; 22(2): 264-72. PMID: 30759242, PMCID: PMC7297089, PII: 5316808, DOI: 10.1093/ntr/ntz021, ISSN: 1469-994X.
Owolabi US, Amraotkar AR, Coulter AR, Singam NSV, Aladili BN, Singh A, Trainor PJ, Mitra R, DeFilippis AP. Change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2020 Feb; 49(2): 235-44. PMID: 31808123, PII: 10.1007/s11239-019-02004-7, DOI: 10.1007/s11239-019-02004-7, ISSN: 1573-742X.
Obisesan OH, Mirbolouk M, Osei AD, Orimoloye OA, Uddin SMI, Dzaye O, El Shahawy O, Al Rifai M, Bhatnagar A, Stokes A, Benjamin EJ, DeFilippis AP, Blaha MJ. Association Between e-Cigarette Use and Depression in the Behavioral Risk Factor Surveillance System, 2016-2017. JAMA Netw Open. 2019 Dec 12/2/2019; 2(12): e1916800. PMID: 31800073, PMCID: PMC6902792, PII: 2756260, DOI: 10.1001/jamanetworkopen.2019.16800, ISSN: 2574-3805.
DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA. Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury. Circulation [print-electronic]. 2019 Nov 11/12/2019; 140(20): 1661-78. PMID: 31416350, PMCID: PMC6855329, DOI: 10.1161/CIRCULATIONAHA.119.040631, ISSN: 1524-4539.
Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circ Heart Fail [print-electronic]. 2019 Nov; 12(11): e006635. PMID: 31707801, PMCID: PMC7008928, DOI: 10.1161/CIRCHEARTFAILURE.119.006635, ISSN: 1941-3297.
Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Dardari ZA, DeFilippis AP, Bhatnagar A, Blaha MJ. The association between e-cigarette use and asthma among never combustible cigarette smokers: behavioral risk factor surveillance system (BRFSS) 2016 & 2017. BMC Pulm Med. 2019 Oct 10/16/2019; 19(1): 180. PMID: 31619218, PMCID: PMC6796489, PII: 10.1186/s12890-019-0950-3, DOI: 10.1186/s12890-019-0950-3, ISSN: 1471-2466.
Bohula EA, Katz JN, van Diepen S, Alviar CL, Baird-Zars VM, Park JG, Barnett CF, Bhattal G, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis A, Granger CB, Hollenberg S, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel R, Overgaard CB, Phreaner N, Roswell RO, Schulman SP, Snell RJ, Solomon MA, Ternus B, Tymchak W, Vikram F, Morrow DA, . Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness. JAMA Cardiol. 2019 Sep 9/1/2019; 4(9): 928-35. PMID: 31339509, PMCID: PMC6659157, PII: 2739025, DOI: 10.1001/jamacardio.2019.2467, ISSN: 2380-6591.
Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Stokes A, Bhatnagar A, Nasir K, Blaha MJ. Association Between E-Cigarette Use and Cardiovascular Disease Among Never and Current Combustible-Cigarette Smokers. Am J Med [print-electronic]. 2019 Aug; 132(8): 949-954.e2. PMID: 30853474, PII: S0002-9343(19)30211-6, DOI: 10.1016/j.amjmed.2019.02.016, ISSN: 1555-7162.
Watson M, Dardari Z, Kianoush S, Hall ME, DeFilippis AP, Keith RJ, Benjamin EJ, Rodriguez CJ, Bhatnagar A, Lima JA, Butler J, Blaha MJ, Rifai MA. Relation Between Cigarette Smoking and Heart Failure (from the Multiethnic Study of Atherosclerosis). Am J Cardiol [print-electronic]. 2019 Jun 6/15/2019; 123(12): 1972-7. PMID: 30967285, PMCID: PMC6529241, PII: S0002-9149(19)30312-1, DOI: 10.1016/j.amjcard.2019.03.015, ISSN: 1879-1913.
DeFilippis AP, Nasir K, Blaha MJ. Myocardial Infarction as a Clinical End Point in Research. Circ Res [print-electronic]. 2019 Jun 6/7/2019; 124(12): 1701-3. PMID: 31170039, DOI: 10.1161/CIRCRESAHA.119.315101, ISSN: 1524-4571.
Keith RJ, Riggs DW, Conklin DJ, Lorkiewicz P, Srivastava S, Bhatnagar A, DeFilippis AP. Nicotine Metabolism in Adults With Type 2 Diabetes. Nicotine Tob Res. 2019 May 5/21/2019; 21(6): 846-9. PMID: 29059414, PMCID: PMC6528156, PII: 4259304, DOI: 10.1093/ntr/ntx214, ISSN: 1469-994X.
Tibuakuu M, Okunrintemi V, Jirru E, Echouffo Tcheugui JB, Orimoloye OA, Mehta PK, DeFilippis AP, Blaha MJ, Michos ED. National Trends in Cessation Counseling, Prescription Medication Use, and Associated Costs Among US Adult Cigarette Smokers. JAMA Netw Open. 2019 May 5/3/2019; 2(5): e194585. PMID: 31125108, PMCID: PMC6632149, PII: 2734073, DOI: 10.1001/jamanetworkopen.2019.4585, ISSN: 2574-3805.
Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol [print-electronic]. 2019 Apr 4/1/2019; 316(4): H801-H827. PMID: 30707616, PMCID: PMC6483019, DOI: 10.1152/ajpheart.00591.2018, ISSN: 1522-1539.
Berg DD, Bohula EA, van Diepen S, Katz JN, Alviar CL, Baird-Zars VM, Barnett CF, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis AP, Haleem A, Hollenberg SM, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel R, Overgaard CB, Park JG, Phreaner N, Roswell RO, Schulman SP, Jeffrey Snell R, Solomon MA, Ternus B, Tymchak W, Vikram F, Morrow DA. Epidemiology of Shock in Contemporary Cardiac Intensive Care Units. Circ Cardiovasc Qual Outcomes. 2019 Mar; 12(3): e005618. PMID: 30879324, DOI: 10.1161/CIRCOUTCOMES.119.005618, ISSN: 1941-7705.
Clark D, Cain LR, Blaha MJ, DeFilippis AP, Mentz RJ, Kamimura D, White WB, Butler KR, Robertson RM, Bhatnagar A, Butler J, Correa A, Benjamin EJ, Hall ME. Cigarette Smoking and Subclinical Peripheral Arterial Disease in Blacks of the Jackson Heart Study. J Am Heart Assoc. 2019 Feb 2/5/2019; 8(3): e010674. PMID: 30672360, PMCID: PMC6405586, DOI: 10.1161/JAHA.118.010674, ISSN: 2047-9980.
Mirbolouk M, Charkhchi P, Orimoloye OA, Uddin SMI, Kianoush S, Jaber R, Bhatnagar A, Benjamin EJ, Hall ME, DeFilippis AP, Maziak W, Nasir K, Blaha MJ. E-Cigarette Use Without a History of Combustible Cigarette Smoking Among U.S. Adults: Behavioral Risk Factor Surveillance System, 2016 [letter]. Ann Intern Med [print-electronic]. 2019 Jan 1/1/2019; 170(1): 76-9. PMID: 30304466, PII: 2706438, DOI: 10.7326/M18-1826, ISSN: 1539-3704.
Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. Association Between Residential Greenness and Cardiovascular Disease Risk. J Am Heart Assoc. 2018 Dec 12/18/2018; 7(24): e009117. PMID: 30561265, PMCID: PMC6405613, DOI: 10.1161/JAHA.118.009117, ISSN: 2047-9980.
Mirbolouk M, Charkhchi P, Kianoush S, Uddin SMI, Orimoloye OA, Jaber R, Bhatnagar A, Benjamin EJ, Hall ME, DeFilippis AP, Maziak W, Nasir K, Blaha MJ. Prevalence and Distribution of E-Cigarette Use Among U.S. Adults: Behavioral Risk Factor Surveillance System, 2016. Ann Intern Med [print-electronic]. 2018 Oct 10/2/2018; 169(7): 429-38. PMID: 30167658, PII: 2698112, DOI: 10.7326/M17-3440, ISSN: 1539-3704.
Uddin SMI, Mirbolouk M, Dardari Z, Feldman DI, Cainzos-Achirica M, DeFilippis AP, Greenland P, Blankstein R, Billups KL, Miner MM, Nasir K, Blaha MJ. Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis [letter]. Circulation. 2018 Jul 7/31/2018; 138(5): 540-2. PMID: 29891569, PMCID: PMC6289871, PII: CIRCULATIONAHA.118.033990, DOI: 10.1161/CIRCULATIONAHA.118.033990, ISSN: 1524-4539.
Jaber RM, Mirbolouk M, DeFilippis AP, Maziak W, Keith R, Payne T, Stokes A, Benjamin E, Bhatnagar A, Blankstein R, Saxena A, Blaha MJ, Nasir K. Electronic Cigarette Use Prevalence, Associated Factors, and Pattern by Cigarette Smoking Status in the United States From NHANES (National Health and Nutrition Examination Survey) 2013-2014. J Am Heart Assoc. 2018 Jul 7/14/2018; 7(14): PMID: 30007934, PMCID: PMC6064855, PII: JAHA.117.008178, DOI: 10.1161/JAHA.117.008178, ISSN: 2047-9980.
DeFilippis AP, Trainor P. When Given a Lemon, Make Lemonade: Revising Cardiovascular Risk Prediction Scores [editorial]. Ann Intern Med [print-electronic]. 2018 Jul 7/3/2018; 169(1): 56-7. PMID: 29868856, PII: 2683614, DOI: 10.7326/M18-1175, ISSN: 1539-3704.
Kamimura D, Cain LR, Mentz RJ, White WB, Blaha MJ, DeFilippis AP, Fox ER, Rodriguez CJ, Keith RJ, Benjamin EJ, Butler J, Bhatnagar A, Robertson RM, Winniford MD, Correa A, Hall ME. Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study. Circulation [print-electronic]. 2018 Jun 6/12/2018; 137(24): 2572-82. PMID: 29661945, PMCID: PMC6085757, PII: CIRCULATIONAHA.117.031912, DOI: 10.1161/CIRCULATIONAHA.117.031912, ISSN: 1524-4539.
Trainor PJ, Yampolskiy RV, DeFilippis AP. Wisdom of artificial crowds feature selection in untargeted metabolomics: An application to the development of a blood-based diagnostic test for thrombotic myocardial infarction. J Biomed Inform [print-electronic]. 2018 May; 81: 53-60. PMID: 29578100, PMCID: PMC5948180, PII: S1532-0464(18)30049-2, DOI: 10.1016/j.jbi.2018.03.007, ISSN: 1532-0480.
Tibuakuu M, Kianoush S, DeFilippis AP, McEvoy JW, Zhao D, Guallar E, Ballantyne CM, Hoogeveen RC, Blaha MJ, Michos ED. Usefulness of Lipoprotein-Associated Phospholipase A2 Activity and C-Reactive Protein in Identifying High-Risk Smokers for Atherosclerotic Cardiovascular Disease (from the Atherosclerosis Risk in Communities Study). Am J Cardiol [print-electronic]. 2018 May 5/1/2018; 121(9): 1056-64. PMID: 29525060, PMCID: PMC5927844, PII: S0002-9149(18)30162-0, DOI: 10.1016/j.amjcard.2018.01.020, ISSN: 1879-1913.
Keith RJ, Fetterman JL, Riggs DW, O'Toole T, Nystoriak JL, Holbrook M, Lorkiewicz P, Bhatnagar A, DeFilippis AP, Hamburg NM. Protocol to assess the impact of tobacco-induced volatile organic compounds on cardiovascular risk in a cross- sectional cohort: Cardiovascular Injury due to Tobacco Use study. BMJ Open. 2018 Mar 3/30/2018; 8(3): e019850. PMID: 29602846, PMCID: PMC5884372, PII: bmjopen-2017-019850, DOI: 10.1136/bmjopen-2017-019850, ISSN: 2044-6055.
White WB, Cain LR, Benjamin EJ, DeFilippis AP, Blaha MJ, Wang W, Okhomina V, Keith RJ, Al Rifai M, Kianoush S, Winniford MD, Robertson RM, Bhatnagar A, Correa A, Hall ME. High-Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2018 Jan 1/12/2018; 7(2): PMID: 29330255, PMCID: PMC5850161, PII: JAHA.117.007413, DOI: 10.1161/JAHA.117.007413, ISSN: 2047-9980.
Kianoush S, DeFilippis AP, Rodriguez CJ, Rifai MA, Benjamin EJ, Hall ME, Ouyang P, Allison MA, Blaha MJ. Race/Ethnicity-Specific Associations between Smoking, Serum Leptin, and Abdominal Fat: The Multi-Ethnic Study of Atherosclerosis. Ethn Dis. 2018; 28(4): 531-8. PMID: 30405297, PMCID: PMC6200307, PII: ed.28.4.531, DOI: 10.18865/ed.28.4.531, ISSN: 1049-510X.
Kianoush S, Al Rifai M, Cainzos-Achirica M, Al-Mallah MH, Tison GH, Yeboah J, Miedema MD, Allison MA, Wong ND, DeFilippis AP, Longstreth W, Nasir K, Budoff MJ, Matsushita K, Blaha MJ. Thoracic extra-coronary calcification for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis [print-electronic]. 2017 Dec; 267: 61-7. PMID: 29100062, PMCID: PMC5705470, PII: S0021-9150(17)31330-8, DOI: 10.1016/j.atherosclerosis.2017.10.010, ISSN: 1879-1484.
Amraotkar AR, Song DD, Otero D, Trainor PJ, Ismail I, Kothari V, Singh A, Moore JB, Rai SN, DeFilippis AP. Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction. Clin Appl Thromb Hemost [print-electronic]. 2017 Nov; 23(8): 1052-9. PMID: 28294633, PMCID: PMC5572529, DOI: 10.1177/1076029616683804, ISSN: 1938-2723.
Kianoush S, Bittencourt MS, Lotufo PA, Bensenor IM, Jones SR, DeFilippis AP, Toth PP, Otvos JD, Tibuakuu M, Hall ME, Harada PHN, Blaha MJ. Association Between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Am Heart Assoc. 2017 Aug 8/23/2017; 6(8): PMID: 28838917, PMCID: PMC5586473, PII: JAHA.117.006545, DOI: 10.1161/JAHA.117.006545, ISSN: 2047-9980.
Kianoush S, Yakoob MY, Al-Rifai M, DeFilippis AP, Bittencourt MS, Duncan BB, Bensenor IM, Bhatnagar A, Lotufo PA, Blaha MJ. Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health). J Am Heart Assoc. 2017 Jun 6/24/2017; 6(6): PMID: 28647689, PMCID: PMC5669156, PII: JAHA.116.005088, DOI: 10.1161/JAHA.116.005088, ISSN: 2047-9980.
Trainor PJ, DeFilippis AP, Rai SN. Evaluation of Classifier Performance for Multiclass Phenotype Discrimination in Untargeted Metabolomics. Metabolites. 2017 Jun 6/21/2017; 7(2): PMID: 28635678, PMCID: PMC5488001, PII: metabo7020030, DOI: 10.3390/metabo7020030, ISSN: 2218-1989.
Trainor PJ, Hill BG, Carlisle SM, Rouchka EC, Rai SN, Bhatnagar A, DeFilippis AP. Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction. J Proteomics [print-electronic]. 2017 May 5/8/2017; 160: 38-46. PMID: 28341595, PMCID: PMC5496773, PII: S1874-3919(17)30098-2, DOI: 10.1016/j.jprot.2017.03.014, ISSN: 1876-7737.
Al Rifai M, DeFilippis AP, McEvoy JW, Hall ME, Acien AN, Jones MR, Keith R, Magid HS, Rodriguez CJ, Barr GR, Benjamin EJ, Robertson RM, Bhatnagar A, Blaha MJ. The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis [print-electronic]. 2017 Mar; 258: 119-30. PMID: 28237909, PMCID: PMC5404388, PII: S0021-9150(17)30023-0, DOI: 10.1016/j.atherosclerosis.2017.01.021, ISSN: 1879-1484.
DeFilippis AP, Young R, McEvoy JW, Michos ED, Sandfort V, Kronmal RA, McClelland RL, Blaha MJ. Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern multi-ethnic cohort. Eur Heart J. 2017 Feb 2/21/2017; 38(8): 598-608. PMID: 27436865, PMCID: PMC5837662, PII: ehw301, DOI: 10.1093/eurheartj/ehw301, ISSN: 1522-9645.
Shah JS, Rai SN, DeFilippis AP, Hill BG, Bhatnagar A, Brock GN. Distribution based nearest neighbor imputation for truncated high dimensional data with applications to pre-clinical and clinical metabolomics studies. BMC Bioinformatics. 2017 Feb 2/20/2017; 18(1): 114. PMID: 28219348, PMCID: PMC5319174, PII: 10.1186/s12859-017-1547-6, DOI: 10.1186/s12859-017-1547-6, ISSN: 1471-2105.
Loughran J, Puthawala T, Sutton BS, Brown LE, Pronovost PJ, DeFilippis AP. The Cardiovascular Intensive Care Unit-An Evolving Model for Health Care Delivery. J Intensive Care Med [print-electronic]. 2017 Feb; 32(2): 116-23. PMID: 26768424, PII: 0885066615624664, DOI: 10.1177/0885066615624664, ISSN: 1525-1489.
Tibuakuu M, Kamimura D, Kianoush S, DeFilippis AP, Al Rifai M, Reynolds LM, White WB, Butler KR, Mosley TH, Turner ST, Kullo IJ, Hall ME, Blaha MJ. The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study. PLoS One. 2017; 12(9): e0184914. PMID: 28922371, PMCID: PMC5602636, PII: PONE-D-17-16574, DOI: 10.1371/journal.pone.0184914, ISSN: 1932-6203.
Sultan A, Zheng Y, Trainor PJ, Siow Y, Amraotkar AR, Hill BG, DeFilippis AP. Circulating Prolidase Activity in Patients with Myocardial Infarction. Front Cardiovasc Med. 2017; 4: 50. PMID: 28824924, PMCID: PMC5535509, DOI: 10.3389/fcvm.2017.00050, ISSN: 2297-055X.
DeFilippis AP, Trainor PJ, Hill BG, Amraotkar AR, Rai SN, Hirsch GA, Rouchka EC, Bhatnagar A. Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease. PLoS One. 2017; 12(4): e0175591. PMID: 28414761, PMCID: PMC5393610, PII: PONE-D-17-00030, DOI: 10.1371/journal.pone.0175591, ISSN: 1932-6203.
Amraotkar AR, Ghafghazi S, Trainor PJ, Hargis CW, Irfan AB, Rai SN, Bhatnagar A, DeFilippis AP. Presence of multiple coronary angiographic characteristics for the diagnosis of acute coronary thrombus. Cardiol J [print-electronic]. 2017; 24(1): 25-34. PMID: 28150291, PMCID: PMC5571861, PII: VM/OJS/J/48736, DOI: 10.5603/CJ.a2017.0004, ISSN: 1897-5593.
DeFilippis AP, Chernyavskiy I, Amraotkar AR, Trainor PJ, Kothari S, Ismail I, Hargis CW, Korley FK, Leibundgut G, Tsimikas S, Rai SN, Bhatnagar A. Circulating levels of plasminogen and oxidized phospholipids bound to plasminogen distinguish between atherothrombotic and non-atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2016 Jul; 42(1): 61-76. PMID: 26510751, PMCID: PMC5403145, PII: 10.1007/s11239-015-1292-5, DOI: 10.1007/s11239-015-1292-5, ISSN: 1573-742X.
Feldman DI, Cainzos-Achirica M, Billups KL, DeFilippis AP, Chitaley K, Greenland P, Stein JH, Budoff MJ, Dardari Z, Miner M, Blumenthal RS, Nasir K, Blaha MJ. Subclinical Vascular Disease and Subsequent Erectile Dysfunction: The Multiethnic Study of Atherosclerosis (MESA). Clin Cardiol [print-electronic]. 2016 May; 39(5): 291-8. PMID: 27145089, PMCID: PMC4879072, DOI: 10.1002/clc.22530, ISSN: 1932-8737.
Amraotkar AR, Pachika A, Grubb KJ, DeFilippis AP. Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5-Fluorouracil. Tex Heart Inst J. 2016 Apr; 43(2): 178-82. PMID: 27127440, PMCID: PMC4845572, DOI: 10.14503/THIJ-15-5100, ISSN: 1526-6702.
Keith RJ, Al Rifai M, Carruba C, De Jarnett N, McEvoy JW, Bhatnagar A, Blaha MJ, Defilippis AP. Tobacco Use, Insulin Resistance, and Risk of Type 2 Diabetes: Results from the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2016; 11(6): e0157592. PMID: 27322410, PMCID: PMC4913922, PII: PONE-D-15-53107, DOI: 10.1371/journal.pone.0157592, ISSN: 1932-6203.
DeFilippis AP, Blaha MJ. Predicted vs Observed Clinical Event Risk for Cardiovascular Disease. JAMA. 2015 Nov 11/17/2015; 314(19): 2082. PMID: 26575067, PII: 2470439, DOI: 10.1001/jama.2015.12916, ISSN: 1538-3598.
DeJarnett N, Yeager R, Conklin DJ, Lee J, O'Toole TE, McCracken J, Abplanalp W, Srivastava S, Riggs DW, Hamzeh I, Wagner S, Chugh A, DeFilippis A, Ciszewski T, Wyatt B, Becher C, Higdon D, Ramos KS, Tollerud DJ, Myers JA, Rai SN, Shah J, Zafar N, Krishnasamy SS, Prabhu SD, Bhatnagar A. Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells. Arterioscler Thromb Vasc Biol [print-electronic]. 2015 Nov; 35(11): 2468-77. PMID: 26293462, PMCID: PMC4862408, PII: ATVBAHA.115.305724, DOI: 10.1161/ATVBAHA.115.305724, ISSN: 1524-4636.
DeFilippis AP, Blaha MJ. Can the AHA-ACC ASCVD risk score be applied outside the United States in Korea?. Atherosclerosis [print-electronic]. 2015 Oct; 242(2): 560-2. PMID: 26318105, PII: S0021-9150(15)30082-4, DOI: 10.1016/j.atherosclerosis.2015.08.019, ISSN: 1879-1484.
Amraotkar AR, Hargis CW, Cambon AC, Rai SN, Keith MC, Ghafghazi S, Bolli R, DeFilippis AP. Comparison of coliform contamination in non-municipal waters consumed by the Mennonite versus the non-Mennonite rural populations. Environ Health Prev Med [print-electronic]. 2015 Sep; 20(5): 338-46. PMID: 26068785, PMCID: PMC4550604, DOI: 10.1007/s12199-015-0472-4, ISSN: 1347-4715.
DeFilippis AP, Young R, Blaha MJ. Calibration and Discrimination Among Multiple Cardiovascular Risk Scores in a Modern Multiethnic Cohort [letter]. Ann Intern Med. 2015 Jul 7/7/2015; 163(1): 68-9. PMID: 26148287, PII: 2381590, DOI: 10.7326/L15-5105-2, ISSN: 1539-3704.
McEvoy JW, Nasir K, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Barr RG, Budoff MJ, Szklo M, Navas-Acien A, Polak JF, Blumenthal RS, Post WS, Blaha MJ. Relationship of cigarette smoking with inflammation and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol [print-electronic]. 2015 Apr; 35(4): 1002-10. PMID: 25745060, PMCID: PMC4484586, PII: ATVBAHA.114.304960, DOI: 10.1161/ATVBAHA.114.304960, ISSN: 1524-4636.
McEvoy JW, Blaha MJ, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Min JK, Shaw LJ, Lloyd-Jones DM, Barr RG, Budoff MJ, Blumenthal RS, Nasir K. Cigarette smoking and cardiovascular events: role of inflammation and subclinical atherosclerosis from the MultiEthnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol [print-electronic]. 2015 Mar; 35(3): 700-9. PMID: 25573855, PMCID: PMC4404404, PII: ATVBAHA.114.304562, DOI: 10.1161/ATVBAHA.114.304562, ISSN: 1524-4636.
DeFilippis AP, Young R, Carrubba CJ, McEvoy JW, Budoff MJ, Blumenthal RS, Kronmal RA, McClelland RL, Nasir K, Blaha MJ. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med. 2015 Feb 2/17/2015; 162(4): 266-75. PMID: 25686167, PMCID: PMC4414494, PII: 2118596, DOI: 10.7326/M14-1281, ISSN: 1539-3704.
DeJarnett N, Conklin DJ, Riggs DW, Myers JA, O'Toole TE, Hamzeh I, Wagner S, Chugh A, Ramos KS, Srivastava S, Higdon D, Tollerud DJ, DeFilippis A, Becher C, Wyatt B, McCracken J, Abplanalp W, Rai SN, Ciszewski T, Xie Z, Yeager R, Prabhu SD, Bhatnagar A. Acrolein exposure is associated with increased cardiovascular disease risk. J Am Heart Assoc. 2014 Aug 8/6/2014; 3(4): PMID: 25099132, PMCID: PMC4310380, PII: jah3635, DOI: 10.1161/JAHA.114.000934, ISSN: 2047-9980.
Korley FK, Schulman SP, Sokoll LJ, DeFilippis AP, Stolbach AI, Bayram JD, Saheed MO, Omron R, Fernandez C, Lwin A, Cai SS, Post WS, Jaffe AS. Troponin elevations only detected with a high-sensitivity assay: clinical correlations and prognostic significance. Acad Emerg Med [print-electronic]. 2014 Jul; 21(7): 727-35. PMID: 25112512, DOI: 10.1111/acem.12417, ISSN: 1553-2712.
Sansbury BE, DeMartino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, Hill BG. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail [print-electronic]. 2014 Jul; 7(4): 634-42. PMID: 24762972, PMCID: PMC4102656, PII: CIRCHEARTFAILURE.114.001151, DOI: 10.1161/CIRCHEARTFAILURE.114.001151, ISSN: 1941-3297.
DeFilippis AP, Rai SN, Cambon A, Miles RJ, Jaffe AS, Moser AB, Jones RO, Bolli R, Schulman SP. Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity. Nutr Metab Cardiovasc Dis [print-electronic]. 2014 Apr; 24(4): 428-33. PMID: 24370448, PMCID: PMC4409424, PII: S0939-4753(13)00213-5, DOI: 10.1016/j.numecd.2013.08.012, ISSN: 1590-3729.
Makadia SS, Blaha M, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin S, Kohli P, Conceicao R, Carvalho J, Nasir K, Blumenthal R, Santos RD. Relation of hepatic steatosis to atherogenic dyslipidemia. Am J Cardiol [print-electronic]. 2013 Nov 11/15/2013; 112(10): 1599-604. PMID: 24012029, PII: S0002-9149(13)01621-4, DOI: 10.1016/j.amjcard.2013.08.001, ISSN: 1879-1913.
Martin SS, Blaha MJ, Elshazly MB, Brinton EA, Toth PP, McEvoy JW, Joshi PH, Kulkarni KR, Mize PD, Kwiterovich PO, Defilippis AP, Blumenthal RS, Jones SR. Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications. J Am Coll Cardiol [print-electronic]. 2013 Aug 8/20/2013; 62(8): 732-9. PMID: 23524048, PII: S0735-1097(13)01098-X, DOI: 10.1016/j.jacc.2013.01.079, ISSN: 1558-3597.
DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, Blumenthal RS, Budoff MJ. Nonalcoholic fatty liver disease and serum lipoproteins: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis [print-electronic]. 2013 Apr; 227(2): 429-36. PMID: 23419204, PMCID: PMC4049078, PII: S0021-9150(13)00058-0, DOI: 10.1016/j.atherosclerosis.2013.01.022, ISSN: 1879-1484.
DeFilippis AP, Oloyede OS, Andrikopoulou E, Saenger AK, Palachuvattil JM, Fasoro YA, Guallar E, Blumenthal RS, Kickler TS, Jaffe AS, Gerstenblith G, Schulman SP, Rade JJ. Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction. Circ J [print-electronic]. 2013; 77(11): 2786-92. PMID: 23985963, PII: DN/JST.JSTAGE/circj/CJ-12-1421, DOI: 10.1253/circj.cj-12-1421, ISSN: 1347-4820.
Bardia A, Arieas ET, Zhang Z, Defilippis A, Tarpinian K, Jeter S, Nguyen A, Henry NL, Flockhart DA, Hayes DF, Hayden J, Storniolo AM, Armstrong DK, Davidson NE, Fetting J, Ouyang P, Wolff AC, Blumenthal RS, Ashen MD, Stearns V. Comparison of breast cancer recurrence risk and cardiovascular disease incidence risk among postmenopausal women with breast cancer. Breast Cancer Res Treat [print-electronic]. 2012 Feb; 131(3): 907-14. PMID: 22042368, PMCID: PMC3582017, DOI: 10.1007/s10549-011-1843-1, ISSN: 1573-7217.
Reed RM, Hashmi S, Eberlein M, Iacono A, Netzer G, DeFilippis A, Girgis RE, Toth PP, Scharf S, Jones S. Impact of lung transplantation on serum lipids in COPD. Respir Med [print-electronic]. 2011 Dec; 105(12): 1961-8. PMID: 22019328, PII: S0954-6111(11)00343-X, DOI: 10.1016/j.rmed.2011.10.003, ISSN: 1532-3064.
DeFilippis AP, Blaha MJ, Ndumele CE, Budoff MJ, Lloyd-Jones DM, McClelland RL, Lakoski SG, Cushman M, Wong ND, Blumenthal RS, Lima J, Nasir K. The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2011 Nov 11/8/2011; 58(20): 2076-83. PMID: 22051329, PMCID: PMC4079464, PII: S0735-1097(11)03051-8, DOI: 10.1016/j.jacc.2011.08.022, ISSN: 1558-3597.
Blaha MJ, Budoff MJ, DeFilippis AP, Blankstein R, Rivera JJ, Agatston A, O'Leary DH, Lima J, Blumenthal RS, Nasir K. Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study. Lancet. 2011 Aug 8/20/2011; 378(9792): 684-92. PMID: 21856482, PMCID: PMC3173039, PII: S0140-6736(11)60784-8, DOI: 10.1016/S0140-6736(11)60784-8, ISSN: 1474-547X.
Reed RM, Iacono A, DeFilippis A, Eberlein M, Girgis RE, Jones S. Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol. J Heart Lung Transplant [print-electronic]. 2011 Jun; 30(6): 674-8. PMID: 21306919, PII: S1053-2498(11)00002-7, DOI: 10.1016/j.healun.2010.12.010, ISSN: 1557-3117.
Reed RM, Iacono A, DeFilippis A, Jones S, Eberlein M, Lechtzin N, Girgis RE. Statin therapy is associated with decreased pulmonary vascular pressures in severe COPD. COPD. 2011 Apr; 8(2): 96-102. PMID: 21495837, DOI: 10.3109/15412555.2011.558545, ISSN: 1541-2563.
Blaha MJ, DeFilippis AP, Rivera JJ, Budoff MJ, Blankstein R, Agatston A, Szklo M, Lakoski SG, Bertoni AG, Kronmal RA, Blumenthal RS, Nasir K. The relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care [print-electronic]. 2011 Mar; 34(3): 749-51. PMID: 21292863, PMCID: PMC3041221, PII: dc10-1681, DOI: 10.2337/dc10-1681, ISSN: 1935-5548.
McEvoy JW, Blaha MJ, Defilippis AP, Budoff MJ, Nasir K, Blumenthal RS, Jones SR. Coronary artery calcium progression: an important clinical measurement? A review of published reports. J Am Coll Cardiol. 2010 Nov 11/9/2010; 56(20): 1613-22. PMID: 21050970, PII: S0735-1097(10)03725-3, DOI: 10.1016/j.jacc.2010.06.038, ISSN: 1558-3597.
Tota-Maharaj R, Defilippis AP, Blumenthal RS, Blaha MJ. A practical approach to the metabolic syndrome: review of current concepts and management. Curr Opin Cardiol. 2010 Sep; 25(5): 502-12. PMID: 20644468, DOI: 10.1097/HCO.0b013e32833cd474, ISSN: 1531-7080.
Defilippis AP, Blaha MJ, Jacobson TA. Omega-3 Fatty acids for cardiovascular disease prevention. Curr Treat Options Cardiovasc Med. 2010 Aug; 12(4): 365-80. PMID: 20842560, DOI: 10.1007/s11936-010-0079-4, ISSN: 1534-3189.
DeFilippis AP, Kramer HJ, Katz R, Wong ND, Bertoni AG, Carr J, Budoff MJ, Blumenthal RS, Nasir K. Association between coronary artery calcification progression and microalbuminuria: the MESA study. JACC Cardiovasc Imaging. 2010 Jun; 3(6): 595-604. PMID: 20541715, PMCID: PMC4083743, PII: S1936-878X(10)00199-3, DOI: 10.1016/j.jcmg.2010.01.008, ISSN: 1876-7591.
Defilippis AP, Tellez I, Winawer N, Di Francesco L, Manning KD, Kripalani S. On-site Night Float by Attending Physicians: A Model to Improve Resident Education and Patient Care. J Grad Med Educ. 2010 Mar; 2(1): 57-61. PMID: 21975885, PMCID: PMC2931221, PII: JGME-D-09-00073, DOI: 10.4300/JGME-D-09-00073.1, ISSN: 1949-8357.
Rowe DO, DeFilippis A, Dantzler DM, Kripalani S, Doyle J, Sperling L. Assessment of gender-specific preventive cardiovascular knowledge among house staff: Potential impact on cardiovascular management. Gend Med. 2009 Sep; 6(3): 471-8. PMID: 19850243, PII: S1550-8579(09)00094-1, DOI: 10.1016/j.genm.2009.09.002, ISSN: 1878-7398.
Wickramasinghe SR, DeFilippis AP, Lloyd-Jones DM, Blumenthal RS. A convenient tool to profile patients for generalized cardiovascular disease risk in primary care [editorial]. Am J Cardiol [print-electronic]. 2009 Apr 4/15/2009; 103(8): 1174-7. PMID: 19361610, PII: S0002-9149(09)00053-8, DOI: 10.1016/j.amjcard.2008.12.040, ISSN: 1879-1913.
DeFilippis AP, Harper CR, Cotsonis GA, Jacobson TA. Effect of baseline plasma fatty acids on eicosapentaenoic acid levels in individuals supplemented with alpha-linolenic acid. Int J Food Sci Nutr [print-electronic]. 2009; 60 Suppl 5: 28-37. PMID: 19468954, PII: 911691007, DOI: 10.1080/09637480802304481, ISSN: 1465-3478.
Blaha MJ, Bansal S, Rouf R, Golden SH, Blumenthal RS, Defilippis AP. A practical "ABCDE" approach to the metabolic syndrome. Mayo Clin Proc. 2008 Aug; 83(8): 932-41. PMID: 18674478, PII: S0025-6196(11)60770-2, DOI: 10.4065/83.8.932, ISSN: 1942-5546.
DeFilippis AP, Bansal S, Blumenthal RS. Long-term follow-up of the West of Scotland Coronary Prevention Study [letter]. N Engl J Med. 2008 Jan 1/10/2008; 358(2): 194; author reply 194-5. PMID: 18193527, ISSN: 1533-4406.
DeFilippis AP, Larned JM, Cole JH, Nell-Dybdahl C, Miller JI, Sperling LS. Clues to cardiovascular risk: an office-based approach. Prev Cardiol. 2007; 10(1): 36-41. PMID: 17215632, DOI: 10.1111/j.1520-037x.2007.05544.x, ISSN: 1520-037X.
DeFilippis AP, Law K, Curtin S, Eckman JR. Blood is thicker than water: the management of hyperviscosity in adults with cyanotic heart disease. Cardiol Rev. 2007 Jan; 15(1): 31-4. PMID: 17172881, PII: 00045415-200701000-00004, DOI: 10.1097/01.crd.0000214959.82120.97, ISSN: 1538-4683.
DeFilippis AP, Sperling LS. Understanding omega-3's. Am Heart J. 2006 Mar; 151(3): 564-70. PMID: 16504616, PII: S0002-8703(05)00351-0, DOI: 10.1016/j.ahj.2005.03.051, ISSN: 1097-6744.
Harper CR, Edwards MJ, DeFilippis AP, Jacobson TA. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr. 2006 Jan; 136(1): 83-7. PMID: 16365063, PII: 136/1/83, DOI: 10.1093/jn/136.1.83, ISSN: 0022-3166.
Bamford RN, DeFilippis AP, Azimi N, Kurys G, Waldmann TA. The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control. J Immunol. 1998 May 5/1/1998; 160(9): 4418-26. PMID: 9574546, ISSN: 0022-1767.
Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity. 1996 Apr; 4(4): 329-36. PMID: 8612127, PII: S1074-7613(00)80246-0, DOI: 10.1016/s1074-7613(00)80246-0, ISSN: 1074-7613.
Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis AP, Rai SN, Bhatnagar A. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol [print-electronic]. 2021 Mar 3/1/2021; 320(3): H1102-H1111. PMID: 33416460, DOI: 10.1152/ajpheart.00689.2020, ISSN: 1522-1539.
McGraw KE, Riggs DW, Rai S, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy S, Taylor KC, Conklin DJ, DeFilippis AP, Srivastava S, Bhatnagar A. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res [print-electronic]. 2021 Feb 2/24/2021; 196: 110903. PMID: 33636185, PII: S0013-9351(21)00197-3, DOI: 10.1016/j.envres.2021.110903, ISSN: 1096-0953.
Stokes AC, Xie W, Wilson AE, Yang H, Orimoloye OA, Harlow AF, Fetterman JL, DeFilippis AP, Benjamin EJ, Robertson RM, Bhatnagar A, Hamburg NM, Blaha MJ. Association of Cigarette and Electronic Cigarette Use Patterns With Levels of Inflammatory and Oxidative Stress Biomarkers Among US Adults: Population Assessment of Tobacco and Health Study [letter]. Circulation [print-electronic]. 2021 Feb 2/23/2021; 143(8): 869-71. PMID: 33390037, DOI: 10.1161/CIRCULATIONAHA.120.051551, ISSN: 1524-4539.
Irfan AB, Arab C, DeFilippis AP, Lorkiewicz P, Keith RJ, Xie Z, Bhatnagar A, Carll AP. Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine Release. Cardiovasc Toxicol [print-electronic]. 2021 Feb; 21(2): 169-78. PMID: 33043409, PMCID: PMC7855806, PII: 10.1007/s12012-020-09610-5, DOI: 10.1007/s12012-020-09610-5, ISSN: 1559-0259.
Singh A, Coulter AR, Trainor PJ, Singam NSV, Aladili BN, Amraotkar AR, Owolabi US, DeFilippis AP. Flow cytometric evaluation of platelet-leukocyte conjugate stability over time: methodological implications of sample handling and processing. J Thromb Thrombolysis. 2021 Jan; 51(1): 120-8. PMID: 32557223, PMCID: PMC7738362, PII: 10.1007/s11239-020-02186-5, DOI: 10.1007/s11239-020-02186-5, ISSN: 1573-742X.
O'Toole TE, Amraotkar AA, DeFilippis AP, Rai SN, Keith RJ, Baba SP, Lorkiewicz P, Crandell CE, Pariser GL, Wingard CJ, Pope Iii CA, Bhatnagar A. Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial. BMJ Open. 2020 Dec 12/28/2020; 10(12): e039118. PMID: 33372072, PMCID: PMC7772308, PII: bmjopen-2020-039118, DOI: 10.1136/bmjopen-2020-039118, ISSN: 2044-6055.
Chunawala Z, Chang PP, DeFilippis AP, Hall ME, Matsushita K, Caughey MC. Recurrent Admissions for Acute Decompensated Heart Failure Among Patients With and Without Peripheral Artery Disease: The ARIC Study. J Am Heart Assoc [print-electronic]. 2020 Nov 11/3/2020; 9(21): e017174. PMID: 33100106, PMCID: PMC7763414, DOI: 10.1161/JAHA.120.017174, ISSN: 2047-9980.
Uddin SMI, Osei AD, Obisesan OH, El-Shahawy O, Dzaye O, Cainzos-Achirica M, Mirbolouk M, Orimoloye OA, Stokes A, Benjamin EJ, Bhatnagar A, DeFilippis AP, Henry TS, Nasir K, Blaha MJ. Prevalence, Trends, and Distribution of Nicotine and Marijuana use in E-cigarettes among US adults: The Behavioral Risk Factor Surveillance System 2016-2018. Prev Med [print-electronic]. 2020 Oct; 139: 106175. PMID: 32593733, PII: S0091-7435(20)30199-7, DOI: 10.1016/j.ypmed.2020.106175, ISSN: 1096-0260.
Obisesan OH, Osei AD, Uddin SMI, Dzaye O, Cainzos-Achirica M, Mirbolouk M, Orimoloye OA, Sharma G, Al Rifai M, Stokes A, Bhatnagar A, El Shahawy O, Benjamin EJ, DeFilippis AP, Blaha MJ. E-Cigarette Use Patterns and High-Risk Behaviors in Pregnancy: Behavioral Risk Factor Surveillance System, 2016-2018. Am J Prev Med [print-electronic]. 2020 Aug; 59(2): 187-95. PMID: 32362509, PII: S0749-3797(20)30131-8, DOI: 10.1016/j.amepre.2020.02.015, ISSN: 1873-2607.
Sandoval Y, Bielinski SJ, Daniels LB, Blaha MJ, Michos ED, DeFilippis AP, Szklo M, deFilippi C, Larson NB, Decker PA, Jaffe AS. Atherosclerotic Cardiovascular Disease Risk Stratification Based on Measurements of Troponin and Coronary Artery Calcium. J Am Coll Cardiol. 2020 Jul 7/28/2020; 76(4): 357-70. PMID: 32703505, PMCID: PMC7513421, PII: S0735-1097(20)35511-X, DOI: 10.1016/j.jacc.2020.05.057, ISSN: 1558-3597.
Oshunbade AA, Yimer WK, Valle KA, Clark D, Kamimura D, White WB, DeFilippis AP, Blaha MJ, Benjamin EJ, O'Brien EC, Mentz RJ, Fox ER, O'Mara CS, Butler J, Correa A, Hall ME. Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study. J Am Heart Assoc [print-electronic]. 2020 Jun 6/16/2020; 9(12): e014990. PMID: 32517526, PMCID: PMC7429065, DOI: 10.1161/JAHA.119.014990, ISSN: 2047-9980.
van Diepen S, Tymchak W, Bohula EA, Park JG, Daniels LB, Phreaner N, Barnett CF, Kenigsberg BB, DeFilippis A, Singam NS, Barsness GW, Jentzer JC, Ternus B, Morrow DA, Katz JN, . Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry. Am Heart J [print-electronic]. 2020 Apr; 222: 8-14. PMID: 32006910, PII: S0002-8703(20)30019-3, DOI: 10.1016/j.ahj.2020.01.005, ISSN: 1097-6744.
Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MHEM, Zafar N, Krishnasamy S, DeFilippis A, Turner J, Rai SN, Bhatnagar A. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ [print-electronic]. 2020 Mar 3/10/2020; 707: 135435. PMID: 31865083, PMCID: PMC7294698, PII: S0048-9697(19)35428-2, DOI: 10.1016/j.scitotenv.2019.135435, ISSN: 1879-1026.
Centner CS, Murphy EM, Priddy MC, Moore JT, Janis BR, Menze MA, DeFilippis AP, Kopechek JA. Ultrasound-induced molecular delivery to erythrocytes using a microfluidic system. Biomicrofluidics. 2020 Mar; 14(2): 24114. PMID: 32341725, PMCID: PMC7176461, PII: 1.5144617, DOI: 10.1063/1.5144617, ISSN: 1932-1058.
Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Bhatnagar A, Biswal SS, Blaha MJ. Association Between E-Cigarette Use and Chronic Obstructive Pulmonary Disease by Smoking Status: Behavioral Risk Factor Surveillance System 2016 and 2017. Am J Prev Med [print-electronic]. 2020 Mar; 58(3): 336-42. PMID: 31902685, PII: S0749-3797(19)30479-9, DOI: 10.1016/j.amepre.2019.10.014, ISSN: 1873-2607.
Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res. 2020 Feb 2/6/2020; 22(2): 264-72. PMID: 30759242, PMCID: PMC7297089, PII: 5316808, DOI: 10.1093/ntr/ntz021, ISSN: 1469-994X.
Owolabi US, Amraotkar AR, Coulter AR, Singam NSV, Aladili BN, Singh A, Trainor PJ, Mitra R, DeFilippis AP. Change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2020 Feb; 49(2): 235-44. PMID: 31808123, PII: 10.1007/s11239-019-02004-7, DOI: 10.1007/s11239-019-02004-7, ISSN: 1573-742X.
Obisesan OH, Mirbolouk M, Osei AD, Orimoloye OA, Uddin SMI, Dzaye O, El Shahawy O, Al Rifai M, Bhatnagar A, Stokes A, Benjamin EJ, DeFilippis AP, Blaha MJ. Association Between e-Cigarette Use and Depression in the Behavioral Risk Factor Surveillance System, 2016-2017. JAMA Netw Open. 2019 Dec 12/2/2019; 2(12): e1916800. PMID: 31800073, PMCID: PMC6902792, PII: 2756260, DOI: 10.1001/jamanetworkopen.2019.16800, ISSN: 2574-3805.
DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA. Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury. Circulation [print-electronic]. 2019 Nov 11/12/2019; 140(20): 1661-78. PMID: 31416350, PMCID: PMC6855329, DOI: 10.1161/CIRCULATIONAHA.119.040631, ISSN: 1524-4539.
Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circ Heart Fail [print-electronic]. 2019 Nov; 12(11): e006635. PMID: 31707801, PMCID: PMC7008928, DOI: 10.1161/CIRCHEARTFAILURE.119.006635, ISSN: 1941-3297.
Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Dardari ZA, DeFilippis AP, Bhatnagar A, Blaha MJ. The association between e-cigarette use and asthma among never combustible cigarette smokers: behavioral risk factor surveillance system (BRFSS) 2016 & 2017. BMC Pulm Med. 2019 Oct 10/16/2019; 19(1): 180. PMID: 31619218, PMCID: PMC6796489, PII: 10.1186/s12890-019-0950-3, DOI: 10.1186/s12890-019-0950-3, ISSN: 1471-2466.
Bohula EA, Katz JN, van Diepen S, Alviar CL, Baird-Zars VM, Park JG, Barnett CF, Bhattal G, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis A, Granger CB, Hollenberg S, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel R, Overgaard CB, Phreaner N, Roswell RO, Schulman SP, Snell RJ, Solomon MA, Ternus B, Tymchak W, Vikram F, Morrow DA, . Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness. JAMA Cardiol. 2019 Sep 9/1/2019; 4(9): 928-35. PMID: 31339509, PMCID: PMC6659157, PII: 2739025, DOI: 10.1001/jamacardio.2019.2467, ISSN: 2380-6591.
Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Stokes A, Bhatnagar A, Nasir K, Blaha MJ. Association Between E-Cigarette Use and Cardiovascular Disease Among Never and Current Combustible-Cigarette Smokers. Am J Med [print-electronic]. 2019 Aug; 132(8): 949-954.e2. PMID: 30853474, PII: S0002-9343(19)30211-6, DOI: 10.1016/j.amjmed.2019.02.016, ISSN: 1555-7162.
Watson M, Dardari Z, Kianoush S, Hall ME, DeFilippis AP, Keith RJ, Benjamin EJ, Rodriguez CJ, Bhatnagar A, Lima JA, Butler J, Blaha MJ, Rifai MA. Relation Between Cigarette Smoking and Heart Failure (from the Multiethnic Study of Atherosclerosis). Am J Cardiol [print-electronic]. 2019 Jun 6/15/2019; 123(12): 1972-7. PMID: 30967285, PMCID: PMC6529241, PII: S0002-9149(19)30312-1, DOI: 10.1016/j.amjcard.2019.03.015, ISSN: 1879-1913.
DeFilippis AP, Nasir K, Blaha MJ. Myocardial Infarction as a Clinical End Point in Research. Circ Res [print-electronic]. 2019 Jun 6/7/2019; 124(12): 1701-3. PMID: 31170039, DOI: 10.1161/CIRCRESAHA.119.315101, ISSN: 1524-4571.
Keith RJ, Riggs DW, Conklin DJ, Lorkiewicz P, Srivastava S, Bhatnagar A, DeFilippis AP. Nicotine Metabolism in Adults With Type 2 Diabetes. Nicotine Tob Res. 2019 May 5/21/2019; 21(6): 846-9. PMID: 29059414, PMCID: PMC6528156, PII: 4259304, DOI: 10.1093/ntr/ntx214, ISSN: 1469-994X.
Tibuakuu M, Okunrintemi V, Jirru E, Echouffo Tcheugui JB, Orimoloye OA, Mehta PK, DeFilippis AP, Blaha MJ, Michos ED. National Trends in Cessation Counseling, Prescription Medication Use, and Associated Costs Among US Adult Cigarette Smokers. JAMA Netw Open. 2019 May 5/3/2019; 2(5): e194585. PMID: 31125108, PMCID: PMC6632149, PII: 2734073, DOI: 10.1001/jamanetworkopen.2019.4585, ISSN: 2574-3805.
Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol [print-electronic]. 2019 Apr 4/1/2019; 316(4): H801-H827. PMID: 30707616, PMCID: PMC6483019, DOI: 10.1152/ajpheart.00591.2018, ISSN: 1522-1539.
Berg DD, Bohula EA, van Diepen S, Katz JN, Alviar CL, Baird-Zars VM, Barnett CF, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis AP, Haleem A, Hollenberg SM, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel R, Overgaard CB, Park JG, Phreaner N, Roswell RO, Schulman SP, Jeffrey Snell R, Solomon MA, Ternus B, Tymchak W, Vikram F, Morrow DA. Epidemiology of Shock in Contemporary Cardiac Intensive Care Units. Circ Cardiovasc Qual Outcomes. 2019 Mar; 12(3): e005618. PMID: 30879324, DOI: 10.1161/CIRCOUTCOMES.119.005618, ISSN: 1941-7705.
Clark D, Cain LR, Blaha MJ, DeFilippis AP, Mentz RJ, Kamimura D, White WB, Butler KR, Robertson RM, Bhatnagar A, Butler J, Correa A, Benjamin EJ, Hall ME. Cigarette Smoking and Subclinical Peripheral Arterial Disease in Blacks of the Jackson Heart Study. J Am Heart Assoc. 2019 Feb 2/5/2019; 8(3): e010674. PMID: 30672360, PMCID: PMC6405586, DOI: 10.1161/JAHA.118.010674, ISSN: 2047-9980.
Mirbolouk M, Charkhchi P, Orimoloye OA, Uddin SMI, Kianoush S, Jaber R, Bhatnagar A, Benjamin EJ, Hall ME, DeFilippis AP, Maziak W, Nasir K, Blaha MJ. E-Cigarette Use Without a History of Combustible Cigarette Smoking Among U.S. Adults: Behavioral Risk Factor Surveillance System, 2016 [letter]. Ann Intern Med [print-electronic]. 2019 Jan 1/1/2019; 170(1): 76-9. PMID: 30304466, PII: 2706438, DOI: 10.7326/M18-1826, ISSN: 1539-3704.
Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. Association Between Residential Greenness and Cardiovascular Disease Risk. J Am Heart Assoc. 2018 Dec 12/18/2018; 7(24): e009117. PMID: 30561265, PMCID: PMC6405613, DOI: 10.1161/JAHA.118.009117, ISSN: 2047-9980.
Mirbolouk M, Charkhchi P, Kianoush S, Uddin SMI, Orimoloye OA, Jaber R, Bhatnagar A, Benjamin EJ, Hall ME, DeFilippis AP, Maziak W, Nasir K, Blaha MJ. Prevalence and Distribution of E-Cigarette Use Among U.S. Adults: Behavioral Risk Factor Surveillance System, 2016. Ann Intern Med [print-electronic]. 2018 Oct 10/2/2018; 169(7): 429-38. PMID: 30167658, PII: 2698112, DOI: 10.7326/M17-3440, ISSN: 1539-3704.
Uddin SMI, Mirbolouk M, Dardari Z, Feldman DI, Cainzos-Achirica M, DeFilippis AP, Greenland P, Blankstein R, Billups KL, Miner MM, Nasir K, Blaha MJ. Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis [letter]. Circulation. 2018 Jul 7/31/2018; 138(5): 540-2. PMID: 29891569, PMCID: PMC6289871, PII: CIRCULATIONAHA.118.033990, DOI: 10.1161/CIRCULATIONAHA.118.033990, ISSN: 1524-4539.
Jaber RM, Mirbolouk M, DeFilippis AP, Maziak W, Keith R, Payne T, Stokes A, Benjamin E, Bhatnagar A, Blankstein R, Saxena A, Blaha MJ, Nasir K. Electronic Cigarette Use Prevalence, Associated Factors, and Pattern by Cigarette Smoking Status in the United States From NHANES (National Health and Nutrition Examination Survey) 2013-2014. J Am Heart Assoc. 2018 Jul 7/14/2018; 7(14): PMID: 30007934, PMCID: PMC6064855, PII: JAHA.117.008178, DOI: 10.1161/JAHA.117.008178, ISSN: 2047-9980.
DeFilippis AP, Trainor P. When Given a Lemon, Make Lemonade: Revising Cardiovascular Risk Prediction Scores [editorial]. Ann Intern Med [print-electronic]. 2018 Jul 7/3/2018; 169(1): 56-7. PMID: 29868856, PII: 2683614, DOI: 10.7326/M18-1175, ISSN: 1539-3704.
Kamimura D, Cain LR, Mentz RJ, White WB, Blaha MJ, DeFilippis AP, Fox ER, Rodriguez CJ, Keith RJ, Benjamin EJ, Butler J, Bhatnagar A, Robertson RM, Winniford MD, Correa A, Hall ME. Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study. Circulation [print-electronic]. 2018 Jun 6/12/2018; 137(24): 2572-82. PMID: 29661945, PMCID: PMC6085757, PII: CIRCULATIONAHA.117.031912, DOI: 10.1161/CIRCULATIONAHA.117.031912, ISSN: 1524-4539.
Trainor PJ, Yampolskiy RV, DeFilippis AP. Wisdom of artificial crowds feature selection in untargeted metabolomics: An application to the development of a blood-based diagnostic test for thrombotic myocardial infarction. J Biomed Inform [print-electronic]. 2018 May; 81: 53-60. PMID: 29578100, PMCID: PMC5948180, PII: S1532-0464(18)30049-2, DOI: 10.1016/j.jbi.2018.03.007, ISSN: 1532-0480.
Tibuakuu M, Kianoush S, DeFilippis AP, McEvoy JW, Zhao D, Guallar E, Ballantyne CM, Hoogeveen RC, Blaha MJ, Michos ED. Usefulness of Lipoprotein-Associated Phospholipase A2 Activity and C-Reactive Protein in Identifying High-Risk Smokers for Atherosclerotic Cardiovascular Disease (from the Atherosclerosis Risk in Communities Study). Am J Cardiol [print-electronic]. 2018 May 5/1/2018; 121(9): 1056-64. PMID: 29525060, PMCID: PMC5927844, PII: S0002-9149(18)30162-0, DOI: 10.1016/j.amjcard.2018.01.020, ISSN: 1879-1913.
Keith RJ, Fetterman JL, Riggs DW, O'Toole T, Nystoriak JL, Holbrook M, Lorkiewicz P, Bhatnagar A, DeFilippis AP, Hamburg NM. Protocol to assess the impact of tobacco-induced volatile organic compounds on cardiovascular risk in a cross- sectional cohort: Cardiovascular Injury due to Tobacco Use study. BMJ Open. 2018 Mar 3/30/2018; 8(3): e019850. PMID: 29602846, PMCID: PMC5884372, PII: bmjopen-2017-019850, DOI: 10.1136/bmjopen-2017-019850, ISSN: 2044-6055.
White WB, Cain LR, Benjamin EJ, DeFilippis AP, Blaha MJ, Wang W, Okhomina V, Keith RJ, Al Rifai M, Kianoush S, Winniford MD, Robertson RM, Bhatnagar A, Correa A, Hall ME. High-Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2018 Jan 1/12/2018; 7(2): PMID: 29330255, PMCID: PMC5850161, PII: JAHA.117.007413, DOI: 10.1161/JAHA.117.007413, ISSN: 2047-9980.
Kianoush S, DeFilippis AP, Rodriguez CJ, Rifai MA, Benjamin EJ, Hall ME, Ouyang P, Allison MA, Blaha MJ. Race/Ethnicity-Specific Associations between Smoking, Serum Leptin, and Abdominal Fat: The Multi-Ethnic Study of Atherosclerosis. Ethn Dis. 2018; 28(4): 531-8. PMID: 30405297, PMCID: PMC6200307, PII: ed.28.4.531, DOI: 10.18865/ed.28.4.531, ISSN: 1049-510X.
Kianoush S, Al Rifai M, Cainzos-Achirica M, Al-Mallah MH, Tison GH, Yeboah J, Miedema MD, Allison MA, Wong ND, DeFilippis AP, Longstreth W, Nasir K, Budoff MJ, Matsushita K, Blaha MJ. Thoracic extra-coronary calcification for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis [print-electronic]. 2017 Dec; 267: 61-7. PMID: 29100062, PMCID: PMC5705470, PII: S0021-9150(17)31330-8, DOI: 10.1016/j.atherosclerosis.2017.10.010, ISSN: 1879-1484.
Amraotkar AR, Song DD, Otero D, Trainor PJ, Ismail I, Kothari V, Singh A, Moore JB, Rai SN, DeFilippis AP. Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction. Clin Appl Thromb Hemost [print-electronic]. 2017 Nov; 23(8): 1052-9. PMID: 28294633, PMCID: PMC5572529, DOI: 10.1177/1076029616683804, ISSN: 1938-2723.
Kianoush S, Bittencourt MS, Lotufo PA, Bensenor IM, Jones SR, DeFilippis AP, Toth PP, Otvos JD, Tibuakuu M, Hall ME, Harada PHN, Blaha MJ. Association Between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Am Heart Assoc. 2017 Aug 8/23/2017; 6(8): PMID: 28838917, PMCID: PMC5586473, PII: JAHA.117.006545, DOI: 10.1161/JAHA.117.006545, ISSN: 2047-9980.
Kianoush S, Yakoob MY, Al-Rifai M, DeFilippis AP, Bittencourt MS, Duncan BB, Bensenor IM, Bhatnagar A, Lotufo PA, Blaha MJ. Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health). J Am Heart Assoc. 2017 Jun 6/24/2017; 6(6): PMID: 28647689, PMCID: PMC5669156, PII: JAHA.116.005088, DOI: 10.1161/JAHA.116.005088, ISSN: 2047-9980.
Trainor PJ, DeFilippis AP, Rai SN. Evaluation of Classifier Performance for Multiclass Phenotype Discrimination in Untargeted Metabolomics. Metabolites. 2017 Jun 6/21/2017; 7(2): PMID: 28635678, PMCID: PMC5488001, PII: metabo7020030, DOI: 10.3390/metabo7020030, ISSN: 2218-1989.
Trainor PJ, Hill BG, Carlisle SM, Rouchka EC, Rai SN, Bhatnagar A, DeFilippis AP. Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction. J Proteomics [print-electronic]. 2017 May 5/8/2017; 160: 38-46. PMID: 28341595, PMCID: PMC5496773, PII: S1874-3919(17)30098-2, DOI: 10.1016/j.jprot.2017.03.014, ISSN: 1876-7737.
Al Rifai M, DeFilippis AP, McEvoy JW, Hall ME, Acien AN, Jones MR, Keith R, Magid HS, Rodriguez CJ, Barr GR, Benjamin EJ, Robertson RM, Bhatnagar A, Blaha MJ. The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis [print-electronic]. 2017 Mar; 258: 119-30. PMID: 28237909, PMCID: PMC5404388, PII: S0021-9150(17)30023-0, DOI: 10.1016/j.atherosclerosis.2017.01.021, ISSN: 1879-1484.
DeFilippis AP, Young R, McEvoy JW, Michos ED, Sandfort V, Kronmal RA, McClelland RL, Blaha MJ. Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern multi-ethnic cohort. Eur Heart J. 2017 Feb 2/21/2017; 38(8): 598-608. PMID: 27436865, PMCID: PMC5837662, PII: ehw301, DOI: 10.1093/eurheartj/ehw301, ISSN: 1522-9645.
Shah JS, Rai SN, DeFilippis AP, Hill BG, Bhatnagar A, Brock GN. Distribution based nearest neighbor imputation for truncated high dimensional data with applications to pre-clinical and clinical metabolomics studies. BMC Bioinformatics. 2017 Feb 2/20/2017; 18(1): 114. PMID: 28219348, PMCID: PMC5319174, PII: 10.1186/s12859-017-1547-6, DOI: 10.1186/s12859-017-1547-6, ISSN: 1471-2105.
Loughran J, Puthawala T, Sutton BS, Brown LE, Pronovost PJ, DeFilippis AP. The Cardiovascular Intensive Care Unit-An Evolving Model for Health Care Delivery. J Intensive Care Med [print-electronic]. 2017 Feb; 32(2): 116-23. PMID: 26768424, PII: 0885066615624664, DOI: 10.1177/0885066615624664, ISSN: 1525-1489.
Tibuakuu M, Kamimura D, Kianoush S, DeFilippis AP, Al Rifai M, Reynolds LM, White WB, Butler KR, Mosley TH, Turner ST, Kullo IJ, Hall ME, Blaha MJ. The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study. PLoS One. 2017; 12(9): e0184914. PMID: 28922371, PMCID: PMC5602636, PII: PONE-D-17-16574, DOI: 10.1371/journal.pone.0184914, ISSN: 1932-6203.
Sultan A, Zheng Y, Trainor PJ, Siow Y, Amraotkar AR, Hill BG, DeFilippis AP. Circulating Prolidase Activity in Patients with Myocardial Infarction. Front Cardiovasc Med. 2017; 4: 50. PMID: 28824924, PMCID: PMC5535509, DOI: 10.3389/fcvm.2017.00050, ISSN: 2297-055X.
DeFilippis AP, Trainor PJ, Hill BG, Amraotkar AR, Rai SN, Hirsch GA, Rouchka EC, Bhatnagar A. Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease. PLoS One. 2017; 12(4): e0175591. PMID: 28414761, PMCID: PMC5393610, PII: PONE-D-17-00030, DOI: 10.1371/journal.pone.0175591, ISSN: 1932-6203.
Amraotkar AR, Ghafghazi S, Trainor PJ, Hargis CW, Irfan AB, Rai SN, Bhatnagar A, DeFilippis AP. Presence of multiple coronary angiographic characteristics for the diagnosis of acute coronary thrombus. Cardiol J [print-electronic]. 2017; 24(1): 25-34. PMID: 28150291, PMCID: PMC5571861, PII: VM/OJS/J/48736, DOI: 10.5603/CJ.a2017.0004, ISSN: 1897-5593.
DeFilippis AP, Chernyavskiy I, Amraotkar AR, Trainor PJ, Kothari S, Ismail I, Hargis CW, Korley FK, Leibundgut G, Tsimikas S, Rai SN, Bhatnagar A. Circulating levels of plasminogen and oxidized phospholipids bound to plasminogen distinguish between atherothrombotic and non-atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2016 Jul; 42(1): 61-76. PMID: 26510751, PMCID: PMC5403145, PII: 10.1007/s11239-015-1292-5, DOI: 10.1007/s11239-015-1292-5, ISSN: 1573-742X.
Feldman DI, Cainzos-Achirica M, Billups KL, DeFilippis AP, Chitaley K, Greenland P, Stein JH, Budoff MJ, Dardari Z, Miner M, Blumenthal RS, Nasir K, Blaha MJ. Subclinical Vascular Disease and Subsequent Erectile Dysfunction: The Multiethnic Study of Atherosclerosis (MESA). Clin Cardiol [print-electronic]. 2016 May; 39(5): 291-8. PMID: 27145089, PMCID: PMC4879072, DOI: 10.1002/clc.22530, ISSN: 1932-8737.
Amraotkar AR, Pachika A, Grubb KJ, DeFilippis AP. Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5-Fluorouracil. Tex Heart Inst J. 2016 Apr; 43(2): 178-82. PMID: 27127440, PMCID: PMC4845572, DOI: 10.14503/THIJ-15-5100, ISSN: 1526-6702.
Keith RJ, Al Rifai M, Carruba C, De Jarnett N, McEvoy JW, Bhatnagar A, Blaha MJ, Defilippis AP. Tobacco Use, Insulin Resistance, and Risk of Type 2 Diabetes: Results from the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2016; 11(6): e0157592. PMID: 27322410, PMCID: PMC4913922, PII: PONE-D-15-53107, DOI: 10.1371/journal.pone.0157592, ISSN: 1932-6203.
DeFilippis AP, Blaha MJ. Predicted vs Observed Clinical Event Risk for Cardiovascular Disease. JAMA. 2015 Nov 11/17/2015; 314(19): 2082. PMID: 26575067, PII: 2470439, DOI: 10.1001/jama.2015.12916, ISSN: 1538-3598.
DeJarnett N, Yeager R, Conklin DJ, Lee J, O'Toole TE, McCracken J, Abplanalp W, Srivastava S, Riggs DW, Hamzeh I, Wagner S, Chugh A, DeFilippis A, Ciszewski T, Wyatt B, Becher C, Higdon D, Ramos KS, Tollerud DJ, Myers JA, Rai SN, Shah J, Zafar N, Krishnasamy SS, Prabhu SD, Bhatnagar A. Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells. Arterioscler Thromb Vasc Biol [print-electronic]. 2015 Nov; 35(11): 2468-77. PMID: 26293462, PMCID: PMC4862408, PII: ATVBAHA.115.305724, DOI: 10.1161/ATVBAHA.115.305724, ISSN: 1524-4636.
DeFilippis AP, Blaha MJ. Can the AHA-ACC ASCVD risk score be applied outside the United States in Korea?. Atherosclerosis [print-electronic]. 2015 Oct; 242(2): 560-2. PMID: 26318105, PII: S0021-9150(15)30082-4, DOI: 10.1016/j.atherosclerosis.2015.08.019, ISSN: 1879-1484.
Amraotkar AR, Hargis CW, Cambon AC, Rai SN, Keith MC, Ghafghazi S, Bolli R, DeFilippis AP. Comparison of coliform contamination in non-municipal waters consumed by the Mennonite versus the non-Mennonite rural populations. Environ Health Prev Med [print-electronic]. 2015 Sep; 20(5): 338-46. PMID: 26068785, PMCID: PMC4550604, DOI: 10.1007/s12199-015-0472-4, ISSN: 1347-4715.
DeFilippis AP, Young R, Blaha MJ. Calibration and Discrimination Among Multiple Cardiovascular Risk Scores in a Modern Multiethnic Cohort [letter]. Ann Intern Med. 2015 Jul 7/7/2015; 163(1): 68-9. PMID: 26148287, PII: 2381590, DOI: 10.7326/L15-5105-2, ISSN: 1539-3704.
McEvoy JW, Nasir K, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Barr RG, Budoff MJ, Szklo M, Navas-Acien A, Polak JF, Blumenthal RS, Post WS, Blaha MJ. Relationship of cigarette smoking with inflammation and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol [print-electronic]. 2015 Apr; 35(4): 1002-10. PMID: 25745060, PMCID: PMC4484586, PII: ATVBAHA.114.304960, DOI: 10.1161/ATVBAHA.114.304960, ISSN: 1524-4636.
McEvoy JW, Blaha MJ, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Min JK, Shaw LJ, Lloyd-Jones DM, Barr RG, Budoff MJ, Blumenthal RS, Nasir K. Cigarette smoking and cardiovascular events: role of inflammation and subclinical atherosclerosis from the MultiEthnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol [print-electronic]. 2015 Mar; 35(3): 700-9. PMID: 25573855, PMCID: PMC4404404, PII: ATVBAHA.114.304562, DOI: 10.1161/ATVBAHA.114.304562, ISSN: 1524-4636.
DeFilippis AP, Young R, Carrubba CJ, McEvoy JW, Budoff MJ, Blumenthal RS, Kronmal RA, McClelland RL, Nasir K, Blaha MJ. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med. 2015 Feb 2/17/2015; 162(4): 266-75. PMID: 25686167, PMCID: PMC4414494, PII: 2118596, DOI: 10.7326/M14-1281, ISSN: 1539-3704.
DeJarnett N, Conklin DJ, Riggs DW, Myers JA, O'Toole TE, Hamzeh I, Wagner S, Chugh A, Ramos KS, Srivastava S, Higdon D, Tollerud DJ, DeFilippis A, Becher C, Wyatt B, McCracken J, Abplanalp W, Rai SN, Ciszewski T, Xie Z, Yeager R, Prabhu SD, Bhatnagar A. Acrolein exposure is associated with increased cardiovascular disease risk. J Am Heart Assoc. 2014 Aug 8/6/2014; 3(4): PMID: 25099132, PMCID: PMC4310380, PII: jah3635, DOI: 10.1161/JAHA.114.000934, ISSN: 2047-9980.
Korley FK, Schulman SP, Sokoll LJ, DeFilippis AP, Stolbach AI, Bayram JD, Saheed MO, Omron R, Fernandez C, Lwin A, Cai SS, Post WS, Jaffe AS. Troponin elevations only detected with a high-sensitivity assay: clinical correlations and prognostic significance. Acad Emerg Med [print-electronic]. 2014 Jul; 21(7): 727-35. PMID: 25112512, DOI: 10.1111/acem.12417, ISSN: 1553-2712.
Sansbury BE, DeMartino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, Hill BG. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail [print-electronic]. 2014 Jul; 7(4): 634-42. PMID: 24762972, PMCID: PMC4102656, PII: CIRCHEARTFAILURE.114.001151, DOI: 10.1161/CIRCHEARTFAILURE.114.001151, ISSN: 1941-3297.
DeFilippis AP, Rai SN, Cambon A, Miles RJ, Jaffe AS, Moser AB, Jones RO, Bolli R, Schulman SP. Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity. Nutr Metab Cardiovasc Dis [print-electronic]. 2014 Apr; 24(4): 428-33. PMID: 24370448, PMCID: PMC4409424, PII: S0939-4753(13)00213-5, DOI: 10.1016/j.numecd.2013.08.012, ISSN: 1590-3729.
Makadia SS, Blaha M, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin S, Kohli P, Conceicao R, Carvalho J, Nasir K, Blumenthal R, Santos RD. Relation of hepatic steatosis to atherogenic dyslipidemia. Am J Cardiol [print-electronic]. 2013 Nov 11/15/2013; 112(10): 1599-604. PMID: 24012029, PII: S0002-9149(13)01621-4, DOI: 10.1016/j.amjcard.2013.08.001, ISSN: 1879-1913.
Martin SS, Blaha MJ, Elshazly MB, Brinton EA, Toth PP, McEvoy JW, Joshi PH, Kulkarni KR, Mize PD, Kwiterovich PO, Defilippis AP, Blumenthal RS, Jones SR. Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications. J Am Coll Cardiol [print-electronic]. 2013 Aug 8/20/2013; 62(8): 732-9. PMID: 23524048, PII: S0735-1097(13)01098-X, DOI: 10.1016/j.jacc.2013.01.079, ISSN: 1558-3597.
DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, Blumenthal RS, Budoff MJ. Nonalcoholic fatty liver disease and serum lipoproteins: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis [print-electronic]. 2013 Apr; 227(2): 429-36. PMID: 23419204, PMCID: PMC4049078, PII: S0021-9150(13)00058-0, DOI: 10.1016/j.atherosclerosis.2013.01.022, ISSN: 1879-1484.
DeFilippis AP, Oloyede OS, Andrikopoulou E, Saenger AK, Palachuvattil JM, Fasoro YA, Guallar E, Blumenthal RS, Kickler TS, Jaffe AS, Gerstenblith G, Schulman SP, Rade JJ. Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction. Circ J [print-electronic]. 2013; 77(11): 2786-92. PMID: 23985963, PII: DN/JST.JSTAGE/circj/CJ-12-1421, DOI: 10.1253/circj.cj-12-1421, ISSN: 1347-4820.
Bardia A, Arieas ET, Zhang Z, Defilippis A, Tarpinian K, Jeter S, Nguyen A, Henry NL, Flockhart DA, Hayes DF, Hayden J, Storniolo AM, Armstrong DK, Davidson NE, Fetting J, Ouyang P, Wolff AC, Blumenthal RS, Ashen MD, Stearns V. Comparison of breast cancer recurrence risk and cardiovascular disease incidence risk among postmenopausal women with breast cancer. Breast Cancer Res Treat [print-electronic]. 2012 Feb; 131(3): 907-14. PMID: 22042368, PMCID: PMC3582017, DOI: 10.1007/s10549-011-1843-1, ISSN: 1573-7217.
Reed RM, Hashmi S, Eberlein M, Iacono A, Netzer G, DeFilippis A, Girgis RE, Toth PP, Scharf S, Jones S. Impact of lung transplantation on serum lipids in COPD. Respir Med [print-electronic]. 2011 Dec; 105(12): 1961-8. PMID: 22019328, PII: S0954-6111(11)00343-X, DOI: 10.1016/j.rmed.2011.10.003, ISSN: 1532-3064.
DeFilippis AP, Blaha MJ, Ndumele CE, Budoff MJ, Lloyd-Jones DM, McClelland RL, Lakoski SG, Cushman M, Wong ND, Blumenthal RS, Lima J, Nasir K. The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2011 Nov 11/8/2011; 58(20): 2076-83. PMID: 22051329, PMCID: PMC4079464, PII: S0735-1097(11)03051-8, DOI: 10.1016/j.jacc.2011.08.022, ISSN: 1558-3597.
Blaha MJ, Budoff MJ, DeFilippis AP, Blankstein R, Rivera JJ, Agatston A, O'Leary DH, Lima J, Blumenthal RS, Nasir K. Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study. Lancet. 2011 Aug 8/20/2011; 378(9792): 684-92. PMID: 21856482, PMCID: PMC3173039, PII: S0140-6736(11)60784-8, DOI: 10.1016/S0140-6736(11)60784-8, ISSN: 1474-547X.
Reed RM, Iacono A, DeFilippis A, Eberlein M, Girgis RE, Jones S. Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol. J Heart Lung Transplant [print-electronic]. 2011 Jun; 30(6): 674-8. PMID: 21306919, PII: S1053-2498(11)00002-7, DOI: 10.1016/j.healun.2010.12.010, ISSN: 1557-3117.
Reed RM, Iacono A, DeFilippis A, Jones S, Eberlein M, Lechtzin N, Girgis RE. Statin therapy is associated with decreased pulmonary vascular pressures in severe COPD. COPD. 2011 Apr; 8(2): 96-102. PMID: 21495837, DOI: 10.3109/15412555.2011.558545, ISSN: 1541-2563.
Blaha MJ, DeFilippis AP, Rivera JJ, Budoff MJ, Blankstein R, Agatston A, Szklo M, Lakoski SG, Bertoni AG, Kronmal RA, Blumenthal RS, Nasir K. The relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care [print-electronic]. 2011 Mar; 34(3): 749-51. PMID: 21292863, PMCID: PMC3041221, PII: dc10-1681, DOI: 10.2337/dc10-1681, ISSN: 1935-5548.
McEvoy JW, Blaha MJ, Defilippis AP, Budoff MJ, Nasir K, Blumenthal RS, Jones SR. Coronary artery calcium progression: an important clinical measurement? A review of published reports. J Am Coll Cardiol. 2010 Nov 11/9/2010; 56(20): 1613-22. PMID: 21050970, PII: S0735-1097(10)03725-3, DOI: 10.1016/j.jacc.2010.06.038, ISSN: 1558-3597.
Tota-Maharaj R, Defilippis AP, Blumenthal RS, Blaha MJ. A practical approach to the metabolic syndrome: review of current concepts and management. Curr Opin Cardiol. 2010 Sep; 25(5): 502-12. PMID: 20644468, DOI: 10.1097/HCO.0b013e32833cd474, ISSN: 1531-7080.
Defilippis AP, Blaha MJ, Jacobson TA. Omega-3 Fatty acids for cardiovascular disease prevention. Curr Treat Options Cardiovasc Med. 2010 Aug; 12(4): 365-80. PMID: 20842560, DOI: 10.1007/s11936-010-0079-4, ISSN: 1534-3189.
DeFilippis AP, Kramer HJ, Katz R, Wong ND, Bertoni AG, Carr J, Budoff MJ, Blumenthal RS, Nasir K. Association between coronary artery calcification progression and microalbuminuria: the MESA study. JACC Cardiovasc Imaging. 2010 Jun; 3(6): 595-604. PMID: 20541715, PMCID: PMC4083743, PII: S1936-878X(10)00199-3, DOI: 10.1016/j.jcmg.2010.01.008, ISSN: 1876-7591.
Defilippis AP, Tellez I, Winawer N, Di Francesco L, Manning KD, Kripalani S. On-site Night Float by Attending Physicians: A Model to Improve Resident Education and Patient Care. J Grad Med Educ. 2010 Mar; 2(1): 57-61. PMID: 21975885, PMCID: PMC2931221, PII: JGME-D-09-00073, DOI: 10.4300/JGME-D-09-00073.1, ISSN: 1949-8357.
Rowe DO, DeFilippis A, Dantzler DM, Kripalani S, Doyle J, Sperling L. Assessment of gender-specific preventive cardiovascular knowledge among house staff: Potential impact on cardiovascular management. Gend Med. 2009 Sep; 6(3): 471-8. PMID: 19850243, PII: S1550-8579(09)00094-1, DOI: 10.1016/j.genm.2009.09.002, ISSN: 1878-7398.
Wickramasinghe SR, DeFilippis AP, Lloyd-Jones DM, Blumenthal RS. A convenient tool to profile patients for generalized cardiovascular disease risk in primary care [editorial]. Am J Cardiol [print-electronic]. 2009 Apr 4/15/2009; 103(8): 1174-7. PMID: 19361610, PII: S0002-9149(09)00053-8, DOI: 10.1016/j.amjcard.2008.12.040, ISSN: 1879-1913.
DeFilippis AP, Harper CR, Cotsonis GA, Jacobson TA. Effect of baseline plasma fatty acids on eicosapentaenoic acid levels in individuals supplemented with alpha-linolenic acid. Int J Food Sci Nutr [print-electronic]. 2009; 60 Suppl 5: 28-37. PMID: 19468954, PII: 911691007, DOI: 10.1080/09637480802304481, ISSN: 1465-3478.
Blaha MJ, Bansal S, Rouf R, Golden SH, Blumenthal RS, Defilippis AP. A practical "ABCDE" approach to the metabolic syndrome. Mayo Clin Proc. 2008 Aug; 83(8): 932-41. PMID: 18674478, PII: S0025-6196(11)60770-2, DOI: 10.4065/83.8.932, ISSN: 1942-5546.
DeFilippis AP, Bansal S, Blumenthal RS. Long-term follow-up of the West of Scotland Coronary Prevention Study [letter]. N Engl J Med. 2008 Jan 1/10/2008; 358(2): 194; author reply 194-5. PMID: 18193527, ISSN: 1533-4406.
DeFilippis AP, Larned JM, Cole JH, Nell-Dybdahl C, Miller JI, Sperling LS. Clues to cardiovascular risk: an office-based approach. Prev Cardiol. 2007; 10(1): 36-41. PMID: 17215632, DOI: 10.1111/j.1520-037x.2007.05544.x, ISSN: 1520-037X.
DeFilippis AP, Law K, Curtin S, Eckman JR. Blood is thicker than water: the management of hyperviscosity in adults with cyanotic heart disease. Cardiol Rev. 2007 Jan; 15(1): 31-4. PMID: 17172881, PII: 00045415-200701000-00004, DOI: 10.1097/01.crd.0000214959.82120.97, ISSN: 1538-4683.
DeFilippis AP, Sperling LS. Understanding omega-3's. Am Heart J. 2006 Mar; 151(3): 564-70. PMID: 16504616, PII: S0002-8703(05)00351-0, DOI: 10.1016/j.ahj.2005.03.051, ISSN: 1097-6744.
Harper CR, Edwards MJ, DeFilippis AP, Jacobson TA. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr. 2006 Jan; 136(1): 83-7. PMID: 16365063, PII: 136/1/83, DOI: 10.1093/jn/136.1.83, ISSN: 0022-3166.
Bamford RN, DeFilippis AP, Azimi N, Kurys G, Waldmann TA. The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control. J Immunol. 1998 May 5/1/1998; 160(9): 4418-26. PMID: 9574546, ISSN: 0022-1767.
Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity. 1996 Apr; 4(4): 329-36. PMID: 8612127, PII: S1074-7613(00)80246-0, DOI: 10.1016/s1074-7613(00)80246-0, ISSN: 1074-7613.
Available Postdoctoral Position Details
Posted: 3/23/2021
Cardiovascular Post-Doctoral Clinical Research Fellow:
We are seeking a Post-Doctoral Clinical Research Fellow to assist with an exciting, NIH funded Cardiovascular research project that will include event adjudication with modern criteria for acute myocardial infarction (MI) subtypes (i.e., type 1 versus type 2 MI), as well as accounting for all non-ischemic myocardial injury events. Despite different prevalence, pathobiology, and prognosis, all NHLBI prospective cohorts adjudicate incident acute myocardial infarction (MI) as a singular entity, as opposed to etiologically distinct MI subtypes defined by the 4th Universal Definition of MI. By adjudicating specific MI phenotypes, and defining their epidemiology, this project will directly enable more precise risk prediction, discovery of novel pathobiology-specific risk factors, and allow for the development more targeted preventive strategies (i.e., anticoagulation for those at risk for type 1 versus type 2 MI). This position will include close collaboration with the Multi-ethnic Study of Atherosclerosis (MESA), a National Institutes of Health research cohort.
The Post-Doctoral Clinical Research Fellow will be integral to myocardial injury adjudication skill acquisition and coordination of effort between study adjudicators, study advisory board, the study Program Coordinator, MESA Data Coordinating Center, MESA Proposals and Publications Committee, MESA Field Centers, statisticians, and co-investigators. The fellow will develop expertise in myocardial injury, multi-center cohort research and opportunities for independent projects will be encouraged. Minimum requirements will include a medical degree, and formal training in epidemiology/statistics, preferably a Master of Public Health or Master of Science and Clinical Research degree. Prior clinical training (residency) will be preferred. Additional course work will be encouraged to enhance the fellow’s career goal of maturing into an independently funded myocardial injury/acute MI translational researcher. The fellow will be located at Vanderbilt University in Dr. DeFilippis’ laboratory, where s/he will have office space, a computer, and administrative support. This position requires someone with excellent interpersonal and communication skills.
Please email cover letter and CV to Andrew DeFilippis, MD, MSc at andrew.defilippis@vumc.org