Gianni Castiglione, Ph.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Biological Sciences
Ph.D., University of Toronto, Toronto, CanadaB.Sc., University of Toronto, Toronto, Canada
Research Description
Molecular Biology
Cell Biology
Research Keywords
Biochemistry Evolution Molecular Biology Cell Biology Ophthalmology
Castiglione GM, Zhou L, Xu Z, Neiman Z, Hung CF, Duh EJ. Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2. PLoS Biol. 2021 Dec; 19(12): e3001510. PMID: 34932561, PMCID: PMC8730403, PII: PBIOLOGY-D-21-00553, DOI: 10.1371/journal.pbio.3001510, ISSN: 1545-7885.

Lam B, Kung YJ, Lin J, Tseng SH, Tsai YC, He L, Castiglione G, Egbert E, Duh EJ, Bloch EM, Tobian AAR, Milstone AM, Roden RBS, Wu TC, Hung CF. In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential. Cell Rep [print-electronic]. 2021 Oct 10/19/2021; 37(3): 109838. PMID: 34648735, PMCID: PMC8491932, PII: S2211-1247(21)01302-4, DOI: 10.1016/j.celrep.2021.109838, ISSN: 2211-1247.

Van Nynatten A, Castiglione GM, de A Gutierrez E, Lovejoy NR, Chang BSW. Recreated Ancestral Opsin Associated with Marine to Freshwater Croaker Invasion Reveals Kinetic and Spectral Adaptation. Mol Biol Evol. 2021 May 5/4/2021; 38(5): 2076-87. PMID: 33481002, PMCID: PMC8097279, PII: 6108109, DOI: 10.1093/molbev/msab008, ISSN: 1537-1719.

Zhou L, Xu Z, Castiglione GM, Soiberman US, Eberhart CG, Duh EJ. ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. Ocul Surf [print-electronic]. 2020 Oct; 18(4): 537-44. PMID: 32544566, PMCID: PMC7293510, PII: S1542-0124(20)30104-X, DOI: 10.1016/j.jtos.2020.06.007, ISSN: 1937-5913.

Castiglione GM, Xu Z, Zhou L, Duh EJ. Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. Nat Commun. 2020 May 5/18/2020; 11(1): 2476. PMID: 32424161, PMCID: PMC7234996, PII: 10.1038/s41467-020-16129-4, DOI: 10.1038/s41467-020-16129-4, ISSN: 2041-1723.

Castiglione GM, Chang BS. Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision. Elife. 2018 Oct 10/26/2018; 7: PMID: 30362942, PMCID: PMC6203435, PII: 35957, DOI: 10.7554/eLife.35957, ISSN: 2050-084X.

Gutierrez EA, Castiglione GM, Morrow JM, Schott RK, Loureiro LO, Lim BK, Chang BSW. Functional Shifts in Bat Dim-Light Visual Pigment Are Associated with Differing Echolocation Abilities and Reveal Molecular Adaptation to Photic-Limited Environments. Mol Biol Evol. 2018 Oct 10/1/2018; 35(10): 2422-34. PMID: 30010964, PII: 5054325, DOI: 10.1093/molbev/msy140, ISSN: 1537-1719.

Castiglione GM, Schott RK, Hauser FE, Chang BSW. Convergent selection pressures drive the evolution of rhodopsin kinetics at high altitudes via nonparallel mechanisms. Evolution. 2018 Jan; 72(1): 170-86. PMID: 29143302, DOI: 10.1111/evo.13396, ISSN: 1558-5646.

Hauser FE, Ilves KL, Schott RK, Castiglione GM, López-Fernández H, Chang BSW. Accelerated Evolution and Functional Divergence of the Dim Light Visual Pigment Accompanies Cichlid Colonization of Central America. Mol Biol Evol. 2017 Oct 10/1/2017; 34(10): 2650-64. PMID: 28957507, PII: 3976051, DOI: 10.1093/molbev/msx192, ISSN: 1537-1719.

Castiglione GM, Hauser FE, Liao BS, Lujan NK, Van Nynatten A, Morrow JM, Schott RK, Bhattacharyya N, Dungan SZ, Chang BSW. Evolution of nonspectral rhodopsin function at high altitudes. Proc Natl Acad Sci U S A [print-electronic]. 2017 Jul 7/11/2017; 114(28): 7385-90. PMID: 28642345, PMCID: PMC5514753, PII: 1705765114, DOI: 10.1073/pnas.1705765114, ISSN: 1091-6490.

Morrow JM, Castiglione GM, Dungan SZ, Tang PL, Bhattacharyya N, Hauser FE, Chang BSW. An experimental comparison of human and bovine rhodopsin provides insight into the molecular basis of retinal disease. FEBS Lett [print-electronic]. 2017 Jun; 591(12): 1720-31. PMID: 28369862, DOI: 10.1002/1873-3468.12637, ISSN: 1873-3468.

Hauser FE, Schott RK, Castiglione GM, Van Nynatten A, Kosyakov A, Tang PL, Gow DA, Chang BS. Comparative sequence analyses of rhodopsin and RPE65 reveal patterns of selective constraint across hereditary retinal disease mutations. Vis Neurosci. 2016; 33: e002. PMID: 26750628, PII: S0952523815000322, DOI: 10.1017/S0952523815000322, ISSN: 1469-8714.

Peek J, Castiglione G, Shi T, Christendat D. Isolation and molecular characterization of the shikimate dehydrogenase domain from the Toxoplasma gondii AROM complex. Mol Biochem Parasitol [print-electronic]. 2014 Mar; 194(1-2): 16-9. PMID: 24731949, PII: S0166-6851(14)00041-3, DOI: 10.1016/j.molbiopara.2014.04.002, ISSN: 1872-9428.