Faculty Appointments
Assistant Professor of Medicine
Assistant Professor of Pathology, Microbiology and ImmunologyAssistant Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Institute of Experimental Medicine, St. Petersburg, RussiaM.S., St. Petersburg State University, St. Petersburg, RussiaB.S., St. Petersburg State University, St. Petersburg, Russia
Research Description
Our research focuses on how obesity and aging reshape immune responses and lead to inflammatory diseases and tumor development. Immune cells are sensitive to their metabolic environment, which affects intracellular metabolism and signaling and fine-tune immune functions. We are interested in understanding how metabolic cues regulate communication between immune cells, focusing on dendritic cells and T cells. Our Lab studies how obesity and aging disturb the immune and metabolic balance and lead to excessive inflammation and impaired immune responses. We decode molecular mechanisms that link immune cell metabolism to immune functions by combining experimental and systems immunology approaches.
Research Keywords
Immunology
Metabolism
Molecular Biology
Systems Biology
Computational Biology
Cancer Biology
Obesity
Aging
Immunometabolism
Publications
Roux-en-Y gastric bypass induces hepatic transcriptomic signatures and plasma metabolite changes indicative of improved cholesterol homeostasis. J Hepatol. 2023 May; PMID: 37230231.
Systems Immunology Approaches to Metabolism. Annu Rev Immunol. 2023 Apr; 41: 317-42. PMID: 37126419.
Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes. Cell Rep. 2023 Jan; 42: PMID: 36708514.
Immune ageing at single-cell resolution. Nat Rev Immunol. 2022 Aug; 22: 484-98. PMID: 34815556.
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. 2021 Jul; 373: PMID: 34083450.
Itaconate confers tolerance to late NLRP3 inflammasome activation. Cell Rep. 2021 Mar; 34: PMID: 33691097.
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging. Immunity. 2021 Jan; 54: 99-115. PMID: 33271118.
Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution. Nat Metab. 2019 Jun; 1: 604-14. PMID: 31701087.
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019 May; 177: 1201-16. PMID: 31031005.
Systems Immunology Approaches to Metabolism. Annu Rev Immunol. 2023 Apr; 41: 317-42. PMID: 37126419.
Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes. Cell Rep. 2023 Jan; 42: PMID: 36708514.
Immune ageing at single-cell resolution. Nat Rev Immunol. 2022 Aug; 22: 484-98. PMID: 34815556.
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. 2021 Jul; 373: PMID: 34083450.
Itaconate confers tolerance to late NLRP3 inflammasome activation. Cell Rep. 2021 Mar; 34: PMID: 33691097.
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging. Immunity. 2021 Jan; 54: 99-115. PMID: 33271118.
Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution. Nat Metab. 2019 Jun; 1: 604-14. PMID: 31701087.
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019 May; 177: 1201-16. PMID: 31031005.