Faculty Appointments
Dean of the School of Medicine, Basic Sciences University Distinguished Professor of Biochemistry
Mary Geddes Stahlman ChairUniversity Distinguished Professor of Chemistry
Education
Ph.D., Physical Chemistry, Massachusetts Institute of Technology, Cambridge, MassachusettsB.S., Chemistry, Juniata College, Huntingdon, Pennsylvania
Research Description
John Kuriyan’s major scientific contributions have been in understanding the regulation of eukaryotic cell signaling proteins, particularly protein kinases such as the Src-family kinases, Abelson tyrosine kinase (Abl), the epidermal growth factor receptor (EGFR) and Ca2+/calmodulin-dependent kinase II (CaMKII). By determining the structure of the cancer drug Gleevec bound to Abl, he determined the origin of Gleevec specificity and provided a framework for understanding resistance. He defined the allosteric mechanism by which the catalytic domains of the EGF receptor are activated and how activation causes subunit exchange and the spread of activation in CaMKII. He has also determined the structural mechanisms of DNA replication processivity factors, which enable high-speed genomic replication. In recent work he has mapped the sensitivity of Ras to mutation and has used electron cryomicroscopy to define the active structure of B-Raf kinase and the Epidermal Growth Factor Receptor (EGFR).
Research Keywords
"structural biology" "cancer biology" "DNA replication" evolution biochemistry oncogene "cell signaling"
Publications
Nocka LM, Eisen TJ, Iavarone AT, Groves JT, Kuriyan J. Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2. Elife. 2023 Apr 4/26/2023; 12: PMID: 37159508, PMCID: PMC10132808, PII: 82676, DOI: 10.7554/eLife.82676, ISSN: 2050-084X.
Bajaj T, Kuriyan J, Gee CL. Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis. PLoS One. 2023; 18(6): e0276413. PMID: 37310965, PMCID: PMC10263333, PII: PONE-D-22-27542, DOI: 10.1371/journal.pone.0276413, ISSN: 1932-6203.
Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT. Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proc Natl Acad Sci U S A [print-electronic]. 2022 Oct 10/4/2022; 119(40): e2210990119. PMID: 36122200, PMCID: PMC9546559, DOI: 10.1073/pnas.2210990119, ISSN: 1091-6490.
Hobbs HT, Shah NH, Shoemaker SR, Amacher JF, Marqusee S, Kuriyan J. Saturation mutagenesis of a predicted ancestral Syk-family kinase. Protein Sci. 2022 Oct; 31(10): e4411. PMID: 36173161, PMCID: PMC9601881, DOI: 10.1002/pro.4411, ISSN: 1469-896X.
Lin CW, Nocka LM, Stinger BL, DeGrandchamp JB, Lew LJN, Alvarez S, Phan HT, Kondo Y, Kuriyan J, Groves JT. A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane. Proc Natl Acad Sci U S A [print-electronic]. 2022 May 5/10/2022; 119(19): e2122531119. PMID: 35507881, PMCID: PMC9181613, DOI: 10.1073/pnas.2122531119, ISSN: 1091-6490.
Hidalgo F, Nocka LM, Shah NH, Gorday K, Latorraca NR, Bandaru P, Templeton S, Lee D, Karandur D, Pelton JG, Marqusee S, Wemmer D, Kuriyan J. A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. Elife. 2022 Mar 3/11/2022; 11: PMID: 35272765, PMCID: PMC8916776, PII: 76595, DOI: 10.7554/eLife.76595, ISSN: 2050-084X.
Hobbs HT, Shah NH, Badroos JM, Gee CL, Marqusee S, Kuriyan J. Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci [print-electronic]. 2021 Dec; 30(12): 2373-84. PMID: 34601763, PMCID: PMC8605373, DOI: 10.1002/pro.4199, ISSN: 1469-896X.
Kondo Y, Paul JW, Subramaniam S, Kuriyan J. New insights into Raf regulation from structural analyses. Curr Opin Struct Biol [print-electronic]. 2021 Dec; 71: 223-31. PMID: 34454301, PII: S0959-440X(21)00107-X, DOI: 10.1016/j.sbi.2021.07.005, ISSN: 1879-033X.
Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife. 2021 Nov 11/30/2021; 10: PMID: 34846302, PMCID: PMC8716103, PII: 73218, DOI: 10.7554/eLife.73218, ISSN: 2050-084X.
Huang WYC, Alvarez S, Kondo Y, Kuriyan J, Groves JT. Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS. Proc Natl Acad Sci U S A. 2021 Nov 11/9/2021; 118(45): PMID: 34740968, PMCID: PMC8694064, PII: 2103598118, DOI: 10.1073/pnas.2103598118, ISSN: 1091-6490.
Manford AG, Mena EL, Shih KY, Gee CL, McMinimy R, Martínez-González B, Sherriff R, Lew B, Zoltek M, Rodríguez-Pérez F, Woldesenbet M, Kuriyan J, Rape M. Structural basis and regulation of the reductive stress response. Cell [print-electronic]. 2021 Oct 10/14/2021; 184(21): 5375-5390.e16-5390.e16. PMID: 34562363, PMCID: PMC8810291, PII: S0092-8674(21)01049-7, DOI: 10.1016/j.cell.2021.09.002, ISSN: 1097-4172.
Leurs U, Klein AB, McSpadden ED, Griem-Krey N, Solbak SMØ, Houlton J, Villumsen IS, Vogensen SB, Hamborg L, Gauger SJ, Palmelund LB, Larsen ASG, Shehata MA, Kelstrup CD, Olsen JV, Bach A, Burnie RO, Kerr DS, Gowing EK, Teurlings SMW, Chi CC, Gee CL, Frølund B, Kornum BR, van Woerden GM, Clausen RP, Kuriyan J, Clarkson AN, Wellendorph P. GHB analogs confer neuroprotection through specific interaction with the CaMKIIa hub domain. Proc Natl Acad Sci U S A. 2021 Aug 8/3/2021; 118(31): PMID: 34330837, PMCID: PMC8346900, PII: 2108079118, DOI: 10.1073/pnas.2108079118, ISSN: 1091-6490.
Subramanian S, Gorday K, Marcus K, Orellana MR, Ren P, Luo XR, O'Donnell ME, Kuriyan J. Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction. Elife. 2021 Apr 4/13/2021; 10: PMID: 33847559, PMCID: PMC8121543, PII: 66181, DOI: 10.7554/eLife.66181, ISSN: 2050-084X.
Mena EL, Jevtic P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M. Structural basis for dimerization quality control. Nature [print-electronic]. 2020 Oct; 586(7829): 452-6. PMID: 32814905, PMCID: PMC8024055, PII: 10.1038/s41586-020-2636-7, DOI: 10.1038/s41586-020-2636-7, ISSN: 1476-4687.
Karandur D, Bhattacharyya M, Xia Z, Lee YK, Muratcioglu S, McAffee D, McSpadden ED, Qiu B, Groves JT, Williams ER, Kuriyan J. Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase. Elife. 2020 Sep 9/9/2020; 9: PMID: 32902386, PMCID: PMC7538161, PII: 57784, DOI: 10.7554/eLife.57784, ISSN: 2050-084X.
Cofsky JC, Karandur D, Huang CJ, Witte IP, Kuriyan J, Doudna JA. CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks. Elife. 2020 Jun 6/10/2020; 9: PMID: 32519675, PMCID: PMC7286691, PII: 55143, DOI: 10.7554/eLife.55143, ISSN: 2050-084X.
Bhattacharyya M, Karandur D, Kuriyan J. Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII). Cold Spring Harb Perspect Biol. 2020 Jun 6/1/2020; 12(6): PMID: 31653643, PMCID: PMC7263085, PII: cshperspect.a035147, DOI: 10.1101/cshperspect.a035147, ISSN: 1943-0264.
Bhattacharyya M, Lee YK, Muratcioglu S, Qiu B, Nyayapati P, Schulman H, Groves JT, Kuriyan J. Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation. Elife. 2020 Mar 3/9/2020; 9: PMID: 32149607, PMCID: PMC7141811, PII: 53670, DOI: 10.7554/eLife.53670, ISSN: 2050-084X.
Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol [print-electronic]. 2019 Nov; 20(11): 1481-93. PMID: 31611699, PMCID: PMC6858552, PII: 10.1038/s41590-019-0502-2, DOI: 10.1038/s41590-019-0502-2, ISSN: 1529-2916.
Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science [print-electronic]. 2019 Oct 10/4/2019; 366(6461): 109-15. PMID: 31604311, PMCID: PMC7007921, PII: science.aay0543, DOI: 10.1126/science.aay0543, ISSN: 1095-9203.
McSpadden ED, Xia Z, Chi CC, Susa AC, Shah NH, Gee CL, Williams ER, Kuriyan J. Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+ /calmodulin-dependent protein kinase II. Protein Sci [print-electronic]. 2019 Jun; 28(6): 1071-82. PMID: 30942928, PMCID: PMC6511747, DOI: 10.1002/pro.3614, ISSN: 1469-896X.
Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT. Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization. Proc Natl Acad Sci U S A [print-electronic]. 2019 May 5/28/2019; 116(22): 10798-803. PMID: 31076553, PMCID: PMC6561188, PII: 1819309116, DOI: 10.1073/pnas.1819309116, ISSN: 1091-6490.
Simonetta KR, Taygerly J, Boyle K, Basham SE, Padovani C, Lou Y, Cummins TJ, Yung SL, von Soly SK, Kayser F, Kuriyan J, Rape M, Cardozo M, Gallop MA, Bence NF, Barsanti PA, Saha A. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 3/29/2019; 10(1): 1402. PMID: 30926793, PMCID: PMC6441019, PII: 10.1038/s41467-019-09358-9, DOI: 10.1038/s41467-019-09358-9, ISSN: 2041-1723.
Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, Groves JT. A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS. Science [print-electronic]. 2019 Mar 3/8/2019; 363(6431): 1098-103. PMID: 30846600, PMCID: PMC6563836, PII: 363/6431/1098, DOI: 10.1126/science.aau5721, ISSN: 1095-9203.
Bandaru P, Kondo Y, Kuriyan J. The Interdependent Activation of Son-of-Sevenless and Ras. Cold Spring Harb Perspect Med. 2019 Feb 2/1/2019; 9(2): PMID: 29610148, PMCID: PMC6360870, PII: cshperspect.a031534, DOI: 10.1101/cshperspect.a031534, ISSN: 2157-1422.
Shah NH, Kuriyan J. Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation. Nat Struct Mol Biol [print-electronic]. 2019 Jan; 26(1): 25-34. PMID: 30598552, PMCID: PMC6463301, PII: 10.1038/s41594-018-0175-9, DOI: 10.1038/s41594-018-0175-9, ISSN: 1545-9985.
Shah NH, Amacher JF, Nocka LM, Kuriyan J. The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases. Crit Rev Biochem Mol Biol [print-electronic]. 2018 Oct; 53(5): 535-63. PMID: 30183386, PMCID: PMC6328253, DOI: 10.1080/10409238.2018.1495173, ISSN: 1549-7798.
Cantor AJ, Shah NH, Kuriyan J. Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites. Proc Natl Acad Sci U S A [print-electronic]. 2018 Jul 7/31/2018; 115(31): E7303-E7312-E7312. PMID: 30012625, PMCID: PMC6077704, PII: 1803598115, DOI: 10.1073/pnas.1803598115, ISSN: 1091-6490.
Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol [print-electronic]. 2018 Jul; 19(7): 733-41. PMID: 29915297, PMCID: PMC6202249, PII: 10.1038/s41590-018-0131-1, DOI: 10.1038/s41590-018-0131-1, ISSN: 1529-2916.
Amacher JF, Hobbs HT, Cantor AC, Shah L, Rivero MJ, Mulchand SA, Kuriyan J. Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates. Protein Sci [print-electronic]. 2018 May; 27(5): 923-32. PMID: 29498112, PMCID: PMC5916117, DOI: 10.1002/pro.3397, ISSN: 1469-896X.
Shah NH, Löbel M, Weiss A, Kuriyan J. Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. Elife. 2018 Mar 3/16/2018; 7: PMID: 29547119, PMCID: PMC5889215, PII: 35190, DOI: 10.7554/eLife.35190, ISSN: 2050-084X.
Karandur D, Nawrotek A, Kuriyan J, Cherfils J. Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane. Proc Natl Acad Sci U S A [print-electronic]. 2017 Oct 10/24/2017; 114(43): 11416-21. PMID: 28923919, PMCID: PMC5664517, PII: 1707970114, DOI: 10.1073/pnas.1707970114, ISSN: 1091-6490.
Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 Sep 9/27/2017; 6: PMID: 28952923, PMCID: PMC5643099, PII: 29002, DOI: 10.7554/eLife.29002, ISSN: 2050-084X.
Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A. A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. Mol Cell [print-electronic]. 2017 Aug 8/3/2017; 67(3): 498-511.e6-511.e6. PMID: 28735895, PMCID: PMC5558854, PII: S1097-2765(17)30458-6, DOI: 10.1016/j.molcel.2017.06.024, ISSN: 1097-4164.
Bandaru P, Shah NH, Bhattacharyya M, Barton JP, Kondo Y, Cofsky JC, Gee CL, Chakraborty AK, Kortemme T, Ranganathan R, Kuriyan J. Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife. 2017 Jul 7/7/2017; 6: PMID: 28686159, PMCID: PMC5538825, PII: e27810, DOI: 10.7554/eLife.27810, ISSN: 2050-084X.
Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS Discov [print-electronic]. 2017 Mar; 22(3): 324-31. PMID: 27932698, PMCID: PMC5491343, PII: S2472-5552(22)06956-8, DOI: 10.1177/1087057116681407, ISSN: 2472-5560.
Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife. 2016 Oct 10/4/2016; 5: PMID: 27700984, PMCID: PMC5089863, PII: e20105, DOI: 10.7554/eLife.20105, ISSN: 2050-084X.
Huang WY, Yan Q, Lin WC, Chung JK, Hansen SD, Christensen SM, Tu HL, Kuriyan J, Groves JT. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc Natl Acad Sci U S A [print-electronic]. 2016 Jul 7/19/2016; 113(29): 8218-23. PMID: 27370798, PMCID: PMC4961118, PII: 1602602113, DOI: 10.1073/pnas.1602602113, ISSN: 1091-6490.
Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J. Molecular basis for multimerization in the activation of the epidermal growth factor receptor. Elife. 2016 Mar 3/28/2016; 5: PMID: 27017828, PMCID: PMC4902571, PII: e14107, DOI: 10.7554/eLife.14107, ISSN: 2050-084X.
Bhattacharyya M, Stratton MM, Going CC, McSpadden ED, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee CL, Barros T, Schulman H, Williams ER, Kuriyan J. Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II. Elife. 2016 Mar 3/7/2016; 5: PMID: 26949248, PMCID: PMC4859805, PII: e13405, DOI: 10.7554/eLife.13405, ISSN: 2050-084X.
Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. J Exp Med [print-electronic]. 2016 Feb 2/8/2016; 213(2): 155-65. PMID: 26783323, PMCID: PMC4749924, PII: jem.20150888, DOI: 10.1084/jem.20150888, ISSN: 1540-9538.
Lorenz S, Bhattacharyya M, Feiler C, Rape M, Kuriyan J. Crystal Structure of a Ube2S-Ubiquitin Conjugate. PLoS One. 2016; 11(2): e0147550. PMID: 26828794, PMCID: PMC4734694, PII: PONE-D-15-33420, DOI: 10.1371/journal.pone.0147550, ISSN: 1932-6203.
Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J. Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor. Mol Cell Biol [print-electronic]. 2015 Sep 9/1/2015; 35(17): 3083-102. PMID: 26124280, PMCID: PMC4525312, PII: MCB.00248-15, DOI: 10.1128/MCB.00248-15, ISSN: 1098-5549.
Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J. Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochem J. 2015 Jun 6/1/2015; 468(2): 283-91. PMID: 25779001, PMCID: PMC5936049, PII: BJ20141492, DOI: 10.1042/BJ20141492, ISSN: 1470-8728.
Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A. The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Sci Signal. 2015 May 5/19/2015; 8(377): ra49. PMID: 25990959, PMCID: PMC4445242, DOI: 10.1126/scisignal.2005596, ISSN: 1937-9145.
Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife. 2015 Feb 2/20/2015; 4: PMID: 25699547, PMCID: PMC4384635, DOI: 10.7554/eLife.06074, ISSN: 2050-084X.
Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J. Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220). PLoS One. 2015; 10(4): e0121177. PMID: 25837374, PMCID: PMC4383440, PII: PONE-D-14-55491, DOI: 10.1371/journal.pone.0121177, ISSN: 1932-6203.
Kovacs E, Zorn JA, Huang Y, Barros T, Kuriyan J. A structural perspective on the regulation of the epidermal growth factor receptor. Annu Rev Biochem [print-electronic]. 2015; 84: 739-64. PMID: 25621509, PMCID: PMC4452390, DOI: 10.1146/annurev-biochem-060614-034402, ISSN: 1545-4509.
Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem J. 2015 Jan 1/1/2015; 465(1): 149-61. PMID: 25287889, PMCID: PMC4410814, PII: BJ20140793, DOI: 10.1042/BJ20140793, ISSN: 1470-8728.
Herzik MA, Jonnalagadda R, Kuriyan J, Marletta MA. Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc Natl Acad Sci U S A [print-electronic]. 2014 Oct 10/7/2014; 111(40): E4156-64-E4164. PMID: 25253889, PMCID: PMC4210026, PII: 1416936111, DOI: 10.1073/pnas.1416936111, ISSN: 1091-6490.
Endres NF, Barros T, Cantor AJ, Kuriyan J. Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases. Trends Biochem Sci [print-electronic]. 2014 Oct; 39(10): 437-46. PMID: 25242369, PII: S0968-0004(14)00141-8, DOI: 10.1016/j.tibs.2014.08.001, ISSN: 0968-0004.
Iversen L, Tu HL, Lin WC, Christensen SM, Abel SM, Iwig J, Wu HJ, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu CH, Stamou D, Chakraborty AK, Kuriyan J, Groves JT. Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics. Science. 2014 Jul 7/4/2014; 345(6192): 50-4. PMID: 24994643, PMCID: PMC4255705, PII: 345/6192/50, DOI: 10.1126/science.1250373, ISSN: 1095-9203.
Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP. Crenolanib is a selective type I pan-FLT3 inhibitor. Proc Natl Acad Sci U S A [print-electronic]. 2014 Apr 4/8/2014; 111(14): 5319-24. PMID: 24623852, PMCID: PMC3986131, PII: 1320661111, DOI: 10.1073/pnas.1320661111, ISSN: 1091-6490.
Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J. Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife. 2014 Feb 2/11/2014; 3: e02490. PMID: 24520169, PMCID: PMC3920281, DOI: 10.7554/eLife.02490, ISSN: 2050-084X.
Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J. Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife. 2014 Jan 1/28/2014; 3: e01610. PMID: 24473075, PMCID: PMC3901001, PII: 3/0/e01610, DOI: 10.7554/eLife.01610, ISSN: 2050-084X.
Wang Q, Zorn JA, Kuriyan J. A structural atlas of kinases inhibited by clinically approved drugs. Methods Enzymol. 2014; 548: 23-67. PMID: 25399641, PII: B978-0-12-397918-6.00002-1, DOI: 10.1016/B978-0-12-397918-6.00002-1, ISSN: 1557-7988.
Engel K, Sasaki T, Wang Q, Kuriyan J. A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation. Biochem J. 2013 Aug 8/1/2013; 453(3): 337-44. PMID: 23734957, PMCID: PMC4048812, PII: BJ20130537, DOI: 10.1042/BJ20130537, ISSN: 1470-8728.
Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife. 2013 Jul 7/30/2013; 2: e00813. PMID: 23908768, PMCID: PMC3728621, PII: 00813, DOI: 10.7554/eLife.00813, ISSN: 2050-084X.
Lorenz S, Cantor AJ, Rape M, Kuriyan J. Macromolecular juggling by ubiquitylation enzymes. BMC Biol. 2013 Jun 6/25/2013; 11: 65. PMID: 23800009, PMCID: PMC3748819, PII: 1741-7007-11-65, DOI: 10.1186/1741-7007-11-65, ISSN: 1741-7007.
Iwig JS, Kuriyan J. Fixing a hole where the Ras gets in. Cell. 2013 Jun 6/6/2013; 153(6): 1191-3. PMID: 23746837, PII: S0092-8674(13)00635-1, DOI: 10.1016/j.cell.2013.05.029, ISSN: 1097-4172.
Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol [print-electronic]. 2013 Jun; 33(11): 2188-201. PMID: 23530057, PMCID: PMC3648074, PII: MCB.01637-12, DOI: 10.1128/MCB.01637-12, ISSN: 1098-5549.
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Gibbs E, Kelman Z, Gulbis JM, O'Donnell M, Kuriyan J, Burgers PM, Hurwitz J. The influence of the proliferating cell nuclear antigen-interacting domain of p21(CIP1) on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymes. J Biol Chem. 1997 Jan 1/24/1997; 272(4): 2373-81. PMID: 8999948, PII: S0021-9258(19)78515-9, DOI: 10.1074/jbc.272.4.2373, ISSN: 0021-9258.
Kuriyan J, Cowburn D. Modular peptide recognition domains in eukaryotic signaling. Annu Rev Biophys Biomol Struct. 1997; 26: 259-88. PMID: 9241420, DOI: 10.1146/annurev.biophys.26.1.259, ISSN: 1056-8700.
Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell. 1996 Oct 10/18/1996; 87(2): 297-306. PMID: 8861913, PII: S0092-8674(00)81347-1, DOI: 10.1016/s0092-8674(00)81347-1, ISSN: 0092-8674.
Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 1996 Oct 10/15/1996; 15(20): 5616-26. PMID: 8896455, PMCID: PMC452306, ISSN: 0261-4189.
Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell. 1996 Jun 6/14/1996; 85(6): 931-42. PMID: 8681387, PII: S0092-8674(00)81276-3, DOI: 10.1016/s0092-8674(00)81276-3, ISSN: 0092-8674.
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Wilson DS, Guenther B, Desplan C, Kuriyan J. High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell. 1995 Sep 9/8/1995; 82(5): 709-19. PMID: 7671301, PII: 0092-8674(95)90468-9, DOI: 10.1016/0092-8674(95)90468-9, ISSN: 0092-8674.
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Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 2/15/1995; 3(2): 215-26. PMID: 7735837, PII: S0969-2126(01)00151-4, DOI: 10.1016/s0969-2126(01)00151-4, ISSN: 0969-2126.
Kuriyan J, Thanos D. Structure of the NF-kappa B transcription factor: a holistic interaction with DNA. Structure. 1995 Feb 2/15/1995; 3(2): 135-41. PMID: 7735829, PII: S0969-2126(01)00143-5, DOI: 10.1016/s0969-2126(01)00143-5, ISSN: 0969-2126.
Krishna TS, Kong XP, Gary S, Burgers PM, Kuriyan J. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell. 1994 Dec 12/30/1994; 79(7): 1233-43. PMID: 8001157, PII: 0092-8674(94)90014-0, DOI: 10.1016/0092-8674(94)90014-0, ISSN: 0092-8674.
Krishna TS, Fenyö D, Kong XP, Gary S, Chait BT, Burgers P, Kuriyan J. Crystallization of proliferating cell nuclear antigen (PCNA) from Saccharomyces cerevisiae. J Mol Biol. 1994 Aug 8/12/1994; 241(2): 265-8. PMID: 7914545, PII: S0022-2836(84)71495-1, DOI: 10.1006/jmbi.1994.1495, ISSN: 0022-2836.
Lee CH, Kominos D, Jacques S, Margolis B, Schlessinger J, Shoelson SE, Kuriyan J. Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure. 1994 May 5/15/1994; 2(5): 423-38. PMID: 7521735, PII: S0969-2126(00)00044-7, DOI: 10.1016/s0969-2126(00)00044-7, ISSN: 0969-2126.
Kuriyan J. First view of a tyrosine phosphatase structure. Structure. 1994 Apr 4/15/1994; 2(4): 327-8. PMID: 8087559, ISSN: 0969-2126.
Waksman G, Krishna TS, Williams CH, Kuriyan J. Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis. J Mol Biol. 1994 Feb 2/25/1994; 236(3): 800-16. PMID: 8114095, PII: S0022283684711909, ISSN: 0022-2836.
Kuriyan J, O'Donnell M. Sliding clamps of DNA polymerases. J Mol Biol. 1993 Dec 12/20/1993; 234(4): 915-25. PMID: 7903401, PII: S0022-2836(83)71644-X, DOI: 10.1006/jmbi.1993.1644, ISSN: 0022-2836.
Martin JL, Bardwell JC, Kuriyan J. Crystal structure of the DsbA protein required for disulphide bond formation in vivo. Nature. 1993 Sep 9/30/1993; 365(6445): 464-8. PMID: 8413591, DOI: 10.1038/365464a0, ISSN: 0028-0836.
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Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell. 1993 Mar 3/12/1993; 72(5): 779-90. PMID: 7680960, PII: 0092-8674(93)90405-F, DOI: 10.1016/0092-8674(93)90405-f, ISSN: 0092-8674.
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Waksman G, Kominos D, Robertson SC, Pant N, Baltimore D, Birge RB, Cowburn D, Hanafusa H, Mayer BJ, Overduin M, Resh MD, Rios CB, Silverman L, Kuriyan J. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature. 1992 Aug 8/20/1992; 358(6388): 646-53. PMID: 1379696, DOI: 10.1038/358646a0, ISSN: 0028-0836.
Kong XP, Onrust R, O'Donnell M, Kuriyan J. Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. Cell. 1992 May 5/1/1992; 69(3): 425-37. PMID: 1349852, PII: 0092-8674(92)90445-I, DOI: 10.1016/0092-8674(92)90445-i, ISSN: 0092-8674.
Henderson GB, Murgolo NJ, Kuriyan J, Osapay K, Kominos D, Berry A, Scrutton NS, Hinchliffe NW, Perham RN, Cerami A. Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. Proc Natl Acad Sci U S A. 1991 Oct 10/1/1991; 88(19): 8769-73. PMID: 1924337, PMCID: PMC52591, DOI: 10.1073/pnas.88.19.8769, ISSN: 0027-8424.
Kuriyan J, Kong XP, Krishna TS, Sweet RM, Murgolo NJ, Field H, Cerami A, Henderson GB. X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution. Proc Natl Acad Sci U S A. 1991 Oct 10/1/1991; 88(19): 8764-8. PMID: 1924336, PMCID: PMC52590, DOI: 10.1073/pnas.88.19.8764, ISSN: 0027-8424.
Kuriyan J, Krishna TS, Wong L, Guenther B, Pahler A, Williams CH, Model P. Convergent evolution of similar function in two structurally divergent enzymes. Nature. 1991 Jul 7/11/1991; 352(6331): 172-4. PMID: 2067578, DOI: 10.1038/352172a0, ISSN: 0028-0836.
Kuriyan J, Weis WI. Rigid protein motion as a model for crystallographic temperature factors. Proc Natl Acad Sci U S A. 1991 Apr 4/1/1991; 88(7): 2773-7. PMID: 2011586, PMCID: PMC51321, DOI: 10.1073/pnas.88.7.2773, ISSN: 0027-8424.
Kuriyan J, Osapay K, Burley SK, Brünger AT, Hendrickson WA, Karplus M. Exploration of disorder in protein structures by X-ray restrained molecular dynamics. Proteins. 1991; 10(4): 340-58. PMID: 1946343, DOI: 10.1002/prot.340100407, ISSN: 0887-3585.
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Kuczera K, Kuriyan J, Karplus M. Temperature dependence of the structure and dynamics of myoglobin. A simulation approach. J Mol Biol. 1990 May 5/20/1990; 213(2): 351-73. PMID: 2342112, PII: S0022-2836(05)80196-2, DOI: 10.1016/S0022-2836(05)80196-2, ISSN: 0022-2836.
Kuriyan J, Wong L, Russel M, Model P. Crystallization and preliminary x-ray characterization of thioredoxin reductase from Escherichia coli. J Biol Chem. 1989 Aug 8/5/1989; 264(22): 12752-3. PMID: 2666412, PII: S0021-9258(18)51548-9, ISSN: 0021-9258.
Kuriyan J, Brünger AT, Karplus M, Hendrickson WA. X-ray refinement of protein structures by simulated annealing: test of the method on myohemerythrin. Acta Crystallogr A. 1989 Jun 6/1/1989; 45 ( Pt 6): 396-409. PMID: 2619971, DOI: 10.1107/s0108767389000437, ISSN: 0108-7673.
Kuriyan J, Pahler A, Simon RJ, Kokubo T, Kaiser ET. The x-ray structure of flavohemoglobin. A semisynthetic hydroxylase. J Am Chem Soc. 1988 Aug 8/1/1988; 110(18): 6261-3. PMID: 22148820, DOI: 10.1021/ja00226a060, ISSN: 0002-7863.
Brünger AT, Kuriyan J, Karplus M. Crystallographic R factor refinement by molecular dynamics. Science. 1987 Jan 1/23/1987; 235(4787): 458-60. PMID: 17810339, PII: 235/4787/458, DOI: 10.1126/science.235.4787.458, ISSN: 0036-8075.
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Kuriyan J, Karplus M, Petsko GA. Estimation of uncertainties in X-ray refinement results by use of perturbed structures. Proteins. 1987; 2(1): 1-12. PMID: 3447165, DOI: 10.1002/prot.340020102, ISSN: 0887-3585.
Kuriyan J, Wilz S, Karplus M, Petsko GA. X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 A resolution. J Mol Biol. 1986 Nov 11/5/1986; 192(1): 133-54. PMID: 3820301, PII: 0022-2836(86)90470-5, DOI: 10.1016/0022-2836(86)90470-5, ISSN: 0022-2836.
Kuriyan J, Petsko GA, Levy RM, Karplus M. Effect of anisotropy and anharmonicity on protein crystallographic refinement. An evaluation by molecular dynamics. J Mol Biol. 1986 Jul 7/20/1986; 190(2): 227-54. PMID: 3795269, PII: 0022-2836(86)90295-0, DOI: 10.1016/0022-2836(86)90295-0, ISSN: 0022-2836.