Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Peking University, Beijing, ChinaM.D., Binzhou Medical College, Binzhou, China
Publications
Riehm JJ, Wang L, Ghadge G, Teng M, Correa AM, Marks JD, Roos RP, Allen MJ. Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS. Neurobiol Dis [print-electronic]. 2018 Jul; 115: 115-26. PMID: 29627580, PMCID: PMC5943144, PII: S0969-9961(18)30093-7, DOI: 10.1016/j.nbd.2018.03.014, ISSN: 1095-953X.
Wang L, et al. Neuromuscular disease diagnosis in the era of next-generation sequencing. In: Next-generation sequencing based clinical molecular diagnosis of human genetic disorders. AG: Springer International Publishing; 2017.
Wang L, et al. Next-generation sequencing in primary immunodeficiency diseases. In: Next-generation sequencing based clinical molecular diagnosis of human genetic disorders. AG: Springer International Publishing; 2017.
Holle JR, Marsh RA, Holdcroft AM, Davies SM, Wang L, Zhang K, Jordan MB. Hemophagocytic lymphohistiocytosis in a female patient due to a heterozygous XIAP mutation and skewed X chromosome inactivation. Pediatr Blood Cancer [print-electronic]. 2015 Jul; 62(7): 1288-90. PMID: 25801017, DOI: 10.1002/pbc.25483, ISSN: 1545-5017.
Valencia CA, Husami A, Holle J, Johnson JA, Qian Y, Mathur A, Wei C, Indugula SR, Zou F, Meng H, Wang L, Li X, Fisher R, Tan T, Hogart Begtrup A, Collins K, Wusik KA, Neilson D, Burrow T, Schorry E, Hopkin R, Keddache M, Harley JB, Kaufman KM, Zhang K. Clinical Impact and Cost-Effectiveness of Whole Exome Sequencing as a Diagnostic Tool: A Pediatric Center's Experience. Front Pediatr. 2015; 3: 67. PMID: 26284228, PMCID: PMC4522872, DOI: 10.3389/fped.2015.00067, ISSN: 2296-2360.
Wang L, Popko B, Tixier E, Roos RP. Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. Neurobiol Dis [print-electronic]. 2014 Nov; 71: 317-24. PMID: 25134731, PMCID: PMC4179984, PII: S0969-9961(14)00241-1, DOI: 10.1016/j.nbd.2014.08.010, ISSN: 1095-953X.
Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. J Biol Chem [print-electronic]. 2013 Jul 7/26/2013; 288(30): 21606-17. PMID: 23760509, PMCID: PMC3724620, PII: S0021-9258(20)45461-4, DOI: 10.1074/jbc.M113.487231, ISSN: 1083-351X.
Wang L, Pytel P, Feltri ML, Wrabetz L, Roos RP. Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice. Neurobiol Dis [print-electronic]. 2012 Oct; 48(1): 52-7. PMID: 22668777, PII: S0969-9961(12)00200-8, DOI: 10.1016/j.nbd.2012.05.014, ISSN: 1095-953X.
Wang L, Popko B, Roos RP. The unfolded protein response in familial amyotrophic lateral sclerosis. Hum Mol Genet [print-electronic]. 2011 Mar 3/1/2011; 20(5): 1008-15. PMID: 21159797, PMCID: PMC3033190, PII: ddq546, DOI: 10.1093/hmg/ddq546, ISSN: 1460-2083.
Wang L, Gutmann DH, Roos RP. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice. Hum Mol Genet [print-electronic]. 2011 Jan 1/15/2011; 20(2): 286-93. PMID: 20962037, PII: ddq463, DOI: 10.1093/hmg/ddq463, ISSN: 1460-2083.
Wang L, Grisotti G, Roos RP. Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons. J Neurochem [print-electronic]. 2010 Apr; 113(1): 166-74. PMID: 20132483, PMCID: PMC2913968, PII: JNC6594, DOI: 10.1111/j.1471-4159.2010.06594.x, ISSN: 1471-4159.
Wang L, Sharma K, Grisotti G, Roos RP. The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis. Neurobiol Dis [print-electronic]. 2009 Aug; 35(2): 234-40. PMID: 19442735, PMCID: PMC2706919, PII: S0969-9961(09)00100-4, DOI: 10.1016/j.nbd.2009.05.002, ISSN: 1095-953X.
Wang L, Deng HX, Grisotti G, Zhai H, Siddique T, Roos RP. Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum Mol Genet [print-electronic]. 2009 May 5/1/2009; 18(9): 1642-51. PMID: 19233858, PMCID: PMC2667291, PII: ddp085, DOI: 10.1093/hmg/ddp085, ISSN: 1460-2083.
Wang L, Sharma K, Deng HX, Siddique T, Grisotti G, Liu E, Roos RP. Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology. Neurobiol Dis [print-electronic]. 2008 Mar; 29(3): 400-8. PMID: 18054242, PII: S0969-9961(07)00236-7, DOI: 10.1016/j.nbd.2007.10.004, ISSN: 1095-953X.
Ghadge GD, Wang L, Sharma K, Monti AL, Bindokas V, Stevens FJ, Roos RP. Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord. Neurobiol Dis [print-electronic]. 2006 Jan; 21(1): 194-205. PMID: 16084730, PII: S0969-9961(05)00200-7, DOI: 10.1016/j.nbd.2005.07.006, ISSN: 0969-9961.
Lu YY, Wang LJ, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I. Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport. Neurosci Res. 2003 Jan; 45(1): 33-40. PMID: 12507722, PII: S0168010202001955, DOI: 10.1016/s0168-0102(02)00195-5, ISSN: 0168-0102.
Muramatsu S, Wang L, Ikeguchi K, Fujimoto K, Nakano I, Okada T, Mizukami H, Hanazono Y, Kume A, Nakano I, Ozawa K. Adeno-associated viral vectors for Parkinson's disease. Int Rev Neurobiol. 2003; 55: 205-22. PMID: 12968538, DOI: 10.1016/s0074-7742(03)01009-2, ISSN: 0074-7742.
Muramatsu S, Wang L, Ikeguchi K, Fujimoto K, Nakano I, Ozawa K. Recombinant adeno-associated viral vectors bring gene therapy for Parkinson's disease closer to reality. J Neurol. 2002 Sep; 249 Suppl 2: II36-40-II40. PMID: 12375062, DOI: 10.1007/s00415-002-1207-1, ISSN: 0340-5354.
Wang LJ, Lu YY, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I. Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J Neurosci. 2002 Aug 8/15/2002; 22(16): 6920-8. PMID: 12177190, PMCID: PMC6757879, PII: 22/16/6920, DOI: 10.1523/JNEUROSCI.22-16-06920.2002, ISSN: 1529-2401.
Wang L, Muramatsu S, Lu Y, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Hanazono Y, Kume A, Urano F, Ichinose H, Nagatsu T, Nakano I, Ozawa K. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease. Gene Ther. 2002 Mar; 9(6): 381-9. PMID: 11960314, DOI: 10.1038/sj.gt.3301682, ISSN: 0969-7128.
Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K. Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther. 2002 Feb 2/10/2002; 13(3): 345-54. PMID: 11860702, DOI: 10.1089/10430340252792486, ISSN: 1043-0342.
Wang L, et al. Neuromuscular disease diagnosis in the era of next-generation sequencing. In: Next-generation sequencing based clinical molecular diagnosis of human genetic disorders. AG: Springer International Publishing; 2017.
Wang L, et al. Next-generation sequencing in primary immunodeficiency diseases. In: Next-generation sequencing based clinical molecular diagnosis of human genetic disorders. AG: Springer International Publishing; 2017.
Holle JR, Marsh RA, Holdcroft AM, Davies SM, Wang L, Zhang K, Jordan MB. Hemophagocytic lymphohistiocytosis in a female patient due to a heterozygous XIAP mutation and skewed X chromosome inactivation. Pediatr Blood Cancer [print-electronic]. 2015 Jul; 62(7): 1288-90. PMID: 25801017, DOI: 10.1002/pbc.25483, ISSN: 1545-5017.
Valencia CA, Husami A, Holle J, Johnson JA, Qian Y, Mathur A, Wei C, Indugula SR, Zou F, Meng H, Wang L, Li X, Fisher R, Tan T, Hogart Begtrup A, Collins K, Wusik KA, Neilson D, Burrow T, Schorry E, Hopkin R, Keddache M, Harley JB, Kaufman KM, Zhang K. Clinical Impact and Cost-Effectiveness of Whole Exome Sequencing as a Diagnostic Tool: A Pediatric Center's Experience. Front Pediatr. 2015; 3: 67. PMID: 26284228, PMCID: PMC4522872, DOI: 10.3389/fped.2015.00067, ISSN: 2296-2360.
Wang L, Popko B, Tixier E, Roos RP. Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. Neurobiol Dis [print-electronic]. 2014 Nov; 71: 317-24. PMID: 25134731, PMCID: PMC4179984, PII: S0969-9961(14)00241-1, DOI: 10.1016/j.nbd.2014.08.010, ISSN: 1095-953X.
Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. J Biol Chem [print-electronic]. 2013 Jul 7/26/2013; 288(30): 21606-17. PMID: 23760509, PMCID: PMC3724620, PII: S0021-9258(20)45461-4, DOI: 10.1074/jbc.M113.487231, ISSN: 1083-351X.
Wang L, Pytel P, Feltri ML, Wrabetz L, Roos RP. Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice. Neurobiol Dis [print-electronic]. 2012 Oct; 48(1): 52-7. PMID: 22668777, PII: S0969-9961(12)00200-8, DOI: 10.1016/j.nbd.2012.05.014, ISSN: 1095-953X.
Wang L, Popko B, Roos RP. The unfolded protein response in familial amyotrophic lateral sclerosis. Hum Mol Genet [print-electronic]. 2011 Mar 3/1/2011; 20(5): 1008-15. PMID: 21159797, PMCID: PMC3033190, PII: ddq546, DOI: 10.1093/hmg/ddq546, ISSN: 1460-2083.
Wang L, Gutmann DH, Roos RP. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice. Hum Mol Genet [print-electronic]. 2011 Jan 1/15/2011; 20(2): 286-93. PMID: 20962037, PII: ddq463, DOI: 10.1093/hmg/ddq463, ISSN: 1460-2083.
Wang L, Grisotti G, Roos RP. Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons. J Neurochem [print-electronic]. 2010 Apr; 113(1): 166-74. PMID: 20132483, PMCID: PMC2913968, PII: JNC6594, DOI: 10.1111/j.1471-4159.2010.06594.x, ISSN: 1471-4159.
Wang L, Sharma K, Grisotti G, Roos RP. The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis. Neurobiol Dis [print-electronic]. 2009 Aug; 35(2): 234-40. PMID: 19442735, PMCID: PMC2706919, PII: S0969-9961(09)00100-4, DOI: 10.1016/j.nbd.2009.05.002, ISSN: 1095-953X.
Wang L, Deng HX, Grisotti G, Zhai H, Siddique T, Roos RP. Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum Mol Genet [print-electronic]. 2009 May 5/1/2009; 18(9): 1642-51. PMID: 19233858, PMCID: PMC2667291, PII: ddp085, DOI: 10.1093/hmg/ddp085, ISSN: 1460-2083.
Wang L, Sharma K, Deng HX, Siddique T, Grisotti G, Liu E, Roos RP. Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology. Neurobiol Dis [print-electronic]. 2008 Mar; 29(3): 400-8. PMID: 18054242, PII: S0969-9961(07)00236-7, DOI: 10.1016/j.nbd.2007.10.004, ISSN: 1095-953X.
Ghadge GD, Wang L, Sharma K, Monti AL, Bindokas V, Stevens FJ, Roos RP. Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord. Neurobiol Dis [print-electronic]. 2006 Jan; 21(1): 194-205. PMID: 16084730, PII: S0969-9961(05)00200-7, DOI: 10.1016/j.nbd.2005.07.006, ISSN: 0969-9961.
Lu YY, Wang LJ, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I. Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport. Neurosci Res. 2003 Jan; 45(1): 33-40. PMID: 12507722, PII: S0168010202001955, DOI: 10.1016/s0168-0102(02)00195-5, ISSN: 0168-0102.
Muramatsu S, Wang L, Ikeguchi K, Fujimoto K, Nakano I, Okada T, Mizukami H, Hanazono Y, Kume A, Nakano I, Ozawa K. Adeno-associated viral vectors for Parkinson's disease. Int Rev Neurobiol. 2003; 55: 205-22. PMID: 12968538, DOI: 10.1016/s0074-7742(03)01009-2, ISSN: 0074-7742.
Muramatsu S, Wang L, Ikeguchi K, Fujimoto K, Nakano I, Ozawa K. Recombinant adeno-associated viral vectors bring gene therapy for Parkinson's disease closer to reality. J Neurol. 2002 Sep; 249 Suppl 2: II36-40-II40. PMID: 12375062, DOI: 10.1007/s00415-002-1207-1, ISSN: 0340-5354.
Wang LJ, Lu YY, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I. Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J Neurosci. 2002 Aug 8/15/2002; 22(16): 6920-8. PMID: 12177190, PMCID: PMC6757879, PII: 22/16/6920, DOI: 10.1523/JNEUROSCI.22-16-06920.2002, ISSN: 1529-2401.
Wang L, Muramatsu S, Lu Y, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Hanazono Y, Kume A, Urano F, Ichinose H, Nagatsu T, Nakano I, Ozawa K. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease. Gene Ther. 2002 Mar; 9(6): 381-9. PMID: 11960314, DOI: 10.1038/sj.gt.3301682, ISSN: 0969-7128.
Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K. Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther. 2002 Feb 2/10/2002; 13(3): 345-54. PMID: 11860702, DOI: 10.1089/10430340252792486, ISSN: 1043-0342.