Faculty Appointments
Assistant Professor of Medicine
Assistant Professor of NeurologyAssistant Professor of Pharmacology
Education
Ph.D., University of Florida, Gainesville, FloridaB.S., University of Florida, Gainesville, Florida
Office Address
1235J Light Hall
Nashville, TN 37232
Nashville, TN 37232
Research Description
My research is focused on understanding the cellular and molecular mechanisms by which cardiovascular risk factors, such as hypertension and blood pressure variability, increase the risk of dementia. One of my goals is to investigate the early mechanisms of autonomic and immune dysfunction to better understand the pathogenesis of cognitive impairment late in hypertension, with the goal of improving early detection of patients at risk and developing better treatment strategies to prevent cognitive decline. My laboratory studies these questions in various mouse models of hypertension utilizing interdisciplinary techniques including measurement of cerebral blood flow regulation, flow cytometry of neuroimmune populations, neurobehavioral testing, and single nuclei profiling of neuronal and glia populations.
Research Keywords
hypertension, dementia, neuroimmunology, cerebral blood flow, neuroscience, neurovascular, Alzheimer's disease
Publications
Iadecola C, Anfray A, Schaeffer S, Hattori Y, Santisteban M, Casey N, Wang G, Strickland M, Zhou P, Holtzman D, Anrather J, Park L. Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Res Sq. 2023 Aug 8/4/2023; PMID: 37577565, PMCID: PMC10418550, PII: rs.3.rs-3222611, DOI: 10.21203/rs.3.rs-3222611/v1.
Santisteban MM, Iadecola C, Carnevale D. Hypertension, Neurovascular Dysfunction, and Cognitive Impairment. Hypertension [print-electronic]. 2023 Jan; 80(1): 22-34. PMID: 36129176, PMCID: PMC9742151, DOI: 10.1161/HYPERTENSIONAHA.122.18085, ISSN: 1524-4563.
Glodzik L, Santisteban MM. Blood-Brain Barrier Crossing Renin-Angiotensin System Drugs: Considerations for Dementia and Cognitive Decline [editorial]. Hypertension [print-electronic]. 2021 Sep; 78(3): 644-6. PMID: 34379433, PMCID: PMC9125564, DOI: 10.1161/HYPERTENSIONAHA.121.17595, ISSN: 1524-4563.
Santisteban MM, Ahn SJ, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, Poon C, Schaeffer S, Segarra SG, Körbelin J, Anrather J, Iadecola C. Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension. Hypertension [print-electronic]. 2020 Sep; 76(3): 795-807. PMID: 32654560, PMCID: PMC7429290, DOI: 10.1161/HYPERTENSIONAHA.120.15581, ISSN: 1524-4563.
Faraco G, Hochrainer K, Segarra SG, Schaeffer S, Santisteban MM, Menon A, Jiang H, Holtzman DM, Anrather J, Iadecola C. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature [print-electronic]. 2019 Oct; 574(7780): 686-90. PMID: 31645758, PMCID: PMC7380655, PII: 10.1038/s41586-019-1688-z, DOI: 10.1038/s41586-019-1688-z, ISSN: 1476-4687.
Santisteban MM, Iadecola C. Hypertension, dietary salt and cognitive impairment. J Cereb Blood Flow Metab [print-electronic]. 2018 Dec; 38(12): 2112-28. PMID: 30295560, PMCID: PMC6282225, DOI: 10.1177/0271678X18803374, ISSN: 1559-7016.
Faraco G, Brea D, Garcia-Bonilla L, Wang G, Racchumi G, Chang H, Buendia I, Santisteban MM, Segarra SG, Koizumi K, Sugiyama Y, Murphy M, Voss H, Anrather J, Iadecola C. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nat Neurosci [print-electronic]. 2018 Feb; 21(2): 240-9. PMID: 29335605, PMCID: PMC6207376, PII: 10.1038/s41593-017-0059-z, DOI: 10.1038/s41593-017-0059-z, ISSN: 1546-1726.
Santisteban MM, Iadecola C, Carnevale D. Hypertension, Neurovascular Dysfunction, and Cognitive Impairment. Hypertension [print-electronic]. 2023 Jan; 80(1): 22-34. PMID: 36129176, PMCID: PMC9742151, DOI: 10.1161/HYPERTENSIONAHA.122.18085, ISSN: 1524-4563.
Glodzik L, Santisteban MM. Blood-Brain Barrier Crossing Renin-Angiotensin System Drugs: Considerations for Dementia and Cognitive Decline [editorial]. Hypertension [print-electronic]. 2021 Sep; 78(3): 644-6. PMID: 34379433, PMCID: PMC9125564, DOI: 10.1161/HYPERTENSIONAHA.121.17595, ISSN: 1524-4563.
Santisteban MM, Ahn SJ, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, Poon C, Schaeffer S, Segarra SG, Körbelin J, Anrather J, Iadecola C. Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension. Hypertension [print-electronic]. 2020 Sep; 76(3): 795-807. PMID: 32654560, PMCID: PMC7429290, DOI: 10.1161/HYPERTENSIONAHA.120.15581, ISSN: 1524-4563.
Faraco G, Hochrainer K, Segarra SG, Schaeffer S, Santisteban MM, Menon A, Jiang H, Holtzman DM, Anrather J, Iadecola C. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature [print-electronic]. 2019 Oct; 574(7780): 686-90. PMID: 31645758, PMCID: PMC7380655, PII: 10.1038/s41586-019-1688-z, DOI: 10.1038/s41586-019-1688-z, ISSN: 1476-4687.
Santisteban MM, Iadecola C. Hypertension, dietary salt and cognitive impairment. J Cereb Blood Flow Metab [print-electronic]. 2018 Dec; 38(12): 2112-28. PMID: 30295560, PMCID: PMC6282225, DOI: 10.1177/0271678X18803374, ISSN: 1559-7016.
Faraco G, Brea D, Garcia-Bonilla L, Wang G, Racchumi G, Chang H, Buendia I, Santisteban MM, Segarra SG, Koizumi K, Sugiyama Y, Murphy M, Voss H, Anrather J, Iadecola C. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nat Neurosci [print-electronic]. 2018 Feb; 21(2): 240-9. PMID: 29335605, PMCID: PMC6207376, PII: 10.1038/s41593-017-0059-z, DOI: 10.1038/s41593-017-0059-z, ISSN: 1546-1726.