Faculty Appointments
Associate Professor of Medicine
Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Microbiology, Yale University, New Haven, ConnecticutM.P.H., Infectious Diseases, University of California, Berkeley, CaliforniaB.S., Biological Sciences, University of California, Irvine, California
Research Description
The Watson lab is interested in understanding how cellular metabolism controls innate immunity and inflammation. Mutations in genes involved in mitochondrial function are associated with a variety of chronic diseases including Parkinson's and Crohn's, cancer, and importantly for us, mycobacterial infection. Our lab leverages the notorious human pathogen Mycobacterium tuberculosis to study how mutations in mitochondrial genes and pathogen virulence factors alter macrophage metabolism and polarize immune responses. By using TB and comparing to other pathogens such as Salmonella, Listeria, we hope to discern what metabolic regulatory mechanisms are specific to TB and which are conserved across all infections, with the ultimate goal of identifying common axes of metabolic dysfunction that precipitate and exacerbate disease.
Research Keywords
Host-Pathogen Interaction, Innate Immunity, Metabolism, Mitochondria, Inflammation, Infection, Tuberculosis, Computa8onal Biology, Immunology, Microbiology, Proteomics, RNA Biology, Cell Biology, Biochemistry
Publications
da Silveira BP, Cohen ND, Lawhon SD, Watson RO, Bordin AI. Protective immune response against Rhodococcus equi: An innate immunity-focused review. Equine Vet J [print-electronic]. 2024 Sep 9/11/2024; PMID: 39258739, DOI: 10.1111/evj.14214, ISSN: 2042-3306.
Mabry CJ, Weindel CG, Stranahan LW, Martinez EL, VanPortfliet JJ, West AP, Patrick KL, Watson RO. Necrosis drives susceptibility to Mycobacterium tuberculosis in POLG mtDNA mutator mice. BioRxiv. 2024 Jul 7/22/2024; PMID: 39091776, PMCID: PMC11291070, PII: 2024.07.17.603991, DOI: 10.1101/2024.07.17.603991, ISSN: 2692-8205.
Weindel CG, Ellzey LM, Coleman AK, Patrick KL, Watson RO. LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia. BioRxiv. 2024 Jul 7/13/2024; PMID: 39026883, PMCID: PMC11257505, PII: 2024.07.09.602769, DOI: 10.1101/2024.07.09.602769, ISSN: 2692-8205.
Cabello AL, Wells K, Peng W, Feng HQ, Wang J, Meyer DF, Noroy C, Zhao ES, Zhang H, Li X, Chang H, Gomez G, Mao Y, Patrick KL, Watson RO, Russell WK, Yu A, Zhong J, Guo F, Li M, Zhou M, Qian X, Kobayashi KS, Song J, Panthee S, Mechref Y, Ficht TA, Qin QM, de Figueiredo P. Brucella-driven host N-glycome remodeling controls infection. Cell Host Microbe [print-electronic]. 2024 Apr 4/10/2024; 32(4): 588-605.e9-605.e9. PMID: 38531364, PII: S1931-3128(24)00083-0, DOI: 10.1016/j.chom.2024.03.003, ISSN: 1934-6069.
Scott HM, Smith MH, Coleman AK, Armijo KS, Chapman MJ, Apostalo SL, Wagner AR, Watson RO, Patrick KL. Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription. Cell Rep [print-electronic]. 2024 Mar 3/26/2024; 43(3): 113816. PMID: 38393946, PMCID: PMC11056844, PII: S2211-1247(24)00144-X, DOI: 10.1016/j.celrep.2024.113816, ISSN: 2211-1247.
Azam S, Armijo KS, Weindel CG, Chapman MJ, Devigne A, Nakagawa S, Hirose T, Carpenter S, Watson RO, Patrick KL. The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle. Proc Natl Acad Sci U S A [print-electronic]. 2024 Feb 2/27/2024; 121(9): e2312587121. PMID: 38381785, PMCID: PMC10907238, DOI: 10.1073/pnas.2312587121, ISSN: 1091-6490.
Ellzey LM, Patrick KL, Watson RO. Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection. Curr Opin Immunol [print-electronic]. 2023 Oct; 84: 102366. PMID: 37453340, PMCID: PMC10711692, PII: S0952-7915(23)00085-7, DOI: 10.1016/j.coi.2023.102366, ISSN: 1879-0372.
Weindel CG, Ellzey LM, Martinez EL, Watson RO, Patrick KL. Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis. Trends Cell Biol [print-electronic]. 2023 Sep; 33(9): 773-87. PMID: 37062616, PMCID: PMC10611448, PII: S0962-8924(23)00039-9, DOI: 10.1016/j.tcb.2023.02.007, ISSN: 1879-3088.
Scott HM, Smith MH, Coleman AK, Apostalo SL, Wagner AR, Watson RO, Patrick KL. Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7. BioRxiv. 2023 Jul 7/11/2023; PMID: 37503164, PMCID: PMC10369877, PII: 2023.05.09.540055, DOI: 10.1101/2023.05.09.540055, ISSN: 2692-8205.
Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS. Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens. PLoS Pathog. 2023 Jun; 19(6): e1011088. PMID: 37352334, PMCID: PMC10325092, PII: PPATHOGENS-D-22-02248, DOI: 10.1371/journal.ppat.1011088, ISSN: 1553-7374.
Wagner AR, Weindel CG, West KO, Scott HM, Watson RO, Patrick KL. SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX. Elife. 2022 Nov 11/21/2022; 11: PMID: 36409059, PMCID: PMC9718523, PII: 82244, DOI: 10.7554/eLife.82244, ISSN: 2050-084X.
Weindel CG, Martinez EL, Zhao X, Mabry CJ, Bell SL, Vail KJ, Coleman AK, VanPortfliet JJ, Zhao B, Wagner AR, Azam S, Scott HM, Li P, West AP, Karpac J, Patrick KL, Watson RO. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell [print-electronic]. 2022 Aug 8/18/2022; 185(17): 3214-3231.e23-3231.e23. PMID: 35907404, PMCID: PMC9531054, PII: S0092-8674(22)00790-5, DOI: 10.1016/j.cell.2022.06.038, ISSN: 1097-4172.
Vail KJ, da Silveira BP, Bell SL, Cohen ND, Bordin AI, Patrick KL, Watson RO. The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages. PLoS Pathog. 2021 Sep; 17(9): e1009888. PMID: 34473814, PMCID: PMC8443056, PII: PPATHOGENS-D-21-00708, DOI: 10.1371/journal.ppat.1009888, ISSN: 1553-7374.
Bell SL, Lopez KL, Cox JS, Patrick KL, Watson RO. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages. MBio [print-electronic]. 2021 Aug 8/31/2021; 12(4): e0187120. PMID: 34225486, PMCID: PMC8406326, DOI: 10.1128/mBio.01871-20, ISSN: 2150-7511.
Lei Y, Guerra Martinez C, Torres-Odio S, Bell SL, Birdwell CE, Bryant JD, Tong CW, Watson RO, West LC, West AP. Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Sci Adv [electronic-print]. 2021 May; 7(22): PMID: 34039599, PMCID: PMC8153723, PII: 7/22/eabe7548, DOI: 10.1126/sciadv.abe7548, ISSN: 2375-2548.
Ding S, Yang J, Feng X, Pandey A, Barhoumi R, Zhang D, Bell SL, Liu Y, da Costa LF, Rice-Ficht A, Watson RO, Patrick KL, Qin QM, Ficht TA, de Figueiredo P. Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes. IScience. 2021 Mar 3/19/2021; 24(3): 102192. PMID: 33718841, PMCID: PMC7920835, PII: S2589-0042(21)00160-7, DOI: 10.1016/j.isci.2021.102192, ISSN: 2589-0042.
Patrick KL, Watson RO. Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection. Infect Immun [electronic-print]. 2021 Mar 3/17/2021; 89(4): PMID: 33558322, PMCID: PMC8090963, PII: IAI.00687-20, DOI: 10.1128/IAI.00687-20, ISSN: 1098-5522.
Cossu D, Watson RO, Farina C. Editorial: A Microbial View of Central Nervous System Disorders: Interplay Between Microorganisms, Neuroinflammation and Behaviour [editorial]. Front Immunol. 2021; 12: 816227. PMID: 34975927, PMCID: PMC8716445, DOI: 10.3389/fimmu.2021.816227, ISSN: 1664-3224.
Wagner AR, Scott HM, West KO, Vail KJ, Fitzsimons TC, Coleman AK, Carter KE, Watson RO, Patrick KL. Global Transcriptomics Uncovers Distinct Contributions From Splicing Regulatory Proteins to the Macrophage Innate Immune Response. Front Immunol. 2021; 12: 656885. PMID: 34305890, PMCID: PMC8299563, DOI: 10.3389/fimmu.2021.656885, ISSN: 1664-3224.
Hoffpauir CT, Bell SL, West KO, Jing T, Wagner AR, Torres-Odio S, Cox JS, West AP, Li P, Patrick KL, Watson RO. TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection. J Immunol [print-electronic]. 2020 Jul 7/1/2020; 205(1): 153-67. PMID: 32404352, PMCID: PMC7313415, PII: jimmunol.1901511, DOI: 10.4049/jimmunol.1901511, ISSN: 1550-6606.
Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. Elife. 2020 Feb 2/14/2020; 9: PMID: 32057291, PMCID: PMC7159881, PII: 51071, DOI: 10.7554/eLife.51071, ISSN: 2050-084X.
West KO, Scott HM, Torres-Odio S, West AP, Patrick KL, Watson RO. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. Cell Rep. 2019 Nov 11/5/2019; 29(6): 1594-1609.e5-1609.e5. PMID: 31693898, PMCID: PMC6981299, PII: S2211-1247(19)31282-3, DOI: 10.1016/j.celrep.2019.09.078, ISSN: 2211-1247.
Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature [print-electronic]. 2019 May; 569(7758): 718-22. PMID: 31118511, PMCID: PMC6596994, PII: 10.1038/s41586-019-1228-x, DOI: 10.1038/s41586-019-1228-x, ISSN: 1476-4687.
Patrick KL, Bell SL, Weindel CG, Watson RO. Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat. Front Cell Infect Microbiol. 2019; 9: 138. PMID: 31192157, PMCID: PMC6546885, DOI: 10.3389/fcimb.2019.00138, ISSN: 2235-2988.
Patrick KL, Wojcechowskyj JA, Bell SL, Riba MN, Jing T, Talmage S, Xu P, Cabello AL, Xu J, Shales M, Jimenez-Morales D, Ficht TA, de Figueiredo P, Samuel JE, Li P, Krogan NJ, Watson RO. Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection. Cell Syst [print-electronic]. 2018 Sep 9/26/2018; 7(3): 323-338.e6-338.e6. PMID: 30077634, PMCID: PMC6160342, PII: S2405-4712(18)30277-1, DOI: 10.1016/j.cels.2018.06.010, ISSN: 2405-4712.
Patrick KL, Bell SL, Watson RO. For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses. J Mol Biol [print-electronic]. 2016 Aug 8/28/2016; 428(17): 3372-86. PMID: 27139640, PII: S0022-2836(16)30111-5, DOI: 10.1016/j.jmb.2016.04.030, ISSN: 1089-8638.
Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW, Cox JS. The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell Host Microbe [print-electronic]. 2015 Jun 6/10/2015; 17(6): 811-9. PMID: 26048136, PMCID: PMC4466081, DOI: 10.1016/j.chom.2015.05.004, ISSN: 1934-6069.
Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature [print-electronic]. 2013 Sep 9/26/2013; 501(7468): 512-6. PMID: 24005326, PMCID: PMC3886920, PII: nature12566, DOI: 10.1038/nature12566, ISSN: 1476-4687.
Watson RO, Manzanillo PS, Cox JS. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell. 2012 Aug 8/17/2012; 150(4): 803-15. PMID: 22901810, PMCID: PMC3708656, PII: S0092-8674(12)00884-7, DOI: 10.1016/j.cell.2012.06.040, ISSN: 1097-4172.
Strachan NJ, Watson RO, Novik V, Hofreuter D, Ogden ID, Galán JE. Sexual dimorphism in campylobacteriosis. Epidemiol Infect [print-electronic]. 2008 Nov; 136(11): 1492-5. PMID: 18062834, PMCID: PMC2870750, PII: S0950268807009934, DOI: 10.1017/S0950268807009934, ISSN: 0950-2688.
Watson RO, Galán JE. Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes. PLoS Pathog. 2008 Jan; 4(1): e14. PMID: 18225954, PMCID: PMC2323279, PII: 07-PLPA-RA-0409, DOI: 10.1371/journal.ppat.0040014, ISSN: 1553-7374.
Watson RO, Novik V, Hofreuter D, Lara-Tejero M, Galán JE. A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection. Infect Immun [print-electronic]. 2007 Apr; 75(4): 1994-2003. PMID: 17194808, PMCID: PMC1865720, PII: IAI.01216-06, DOI: 10.1128/IAI.01216-06, ISSN: 0019-9567.
Hofreuter D, Tsai J, Watson RO, Novik V, Altman B, Benitez M, Clark C, Perbost C, Jarvie T, Du L, Galán JE. Unique features of a highly pathogenic Campylobacter jejuni strain. Infect Immun. 2006 Aug; 74(8): 4694-707. PMID: 16861657, PMCID: PMC1539605, PII: 74/8/4694, DOI: 10.1128/IAI.00210-06, ISSN: 0019-9567.
Watson RO, Galán JE. Signal transduction in Campylobacter jejuni-induced cytokine production. Cell Microbiol. 2005 May; 7(5): 655-65. PMID: 15839895, PII: CMI498, DOI: 10.1111/j.1462-5822.2004.00498.x, ISSN: 1462-5814.
Chaussee MS, Sylva GL, Sturdevant DE, Smoot LM, Graham MR, Watson RO, Musser JM. Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes. Infect Immun. 2002 Feb; 70(2): 762-70. PMID: 11796609, PMCID: PMC127716, DOI: 10.1128/IAI.70.2.762-770.2002, ISSN: 0019-9567.
Murli S, Watson RO, Galán JE. Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells. Cell Microbiol. 2001 Dec; 3(12): 795-810. PMID: 11736992, PII: 158, DOI: 10.1046/j.1462-5822.2001.00158.x, ISSN: 1462-5814.
Chaussee MS, Watson RO, Smoot JC, Musser JM. Identification of Rgg-regulated exoproteins of Streptococcus pyogenes. Infect Immun. 2001 Feb; 69(2): 822-31. PMID: 11159974, PMCID: PMC97958, DOI: 10.1128/IAI.69.2.822-831.2001, ISSN: 0019-9567.
Mabry CJ, Weindel CG, Stranahan LW, Martinez EL, VanPortfliet JJ, West AP, Patrick KL, Watson RO. Necrosis drives susceptibility to Mycobacterium tuberculosis in POLG mtDNA mutator mice. BioRxiv. 2024 Jul 7/22/2024; PMID: 39091776, PMCID: PMC11291070, PII: 2024.07.17.603991, DOI: 10.1101/2024.07.17.603991, ISSN: 2692-8205.
Weindel CG, Ellzey LM, Coleman AK, Patrick KL, Watson RO. LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia. BioRxiv. 2024 Jul 7/13/2024; PMID: 39026883, PMCID: PMC11257505, PII: 2024.07.09.602769, DOI: 10.1101/2024.07.09.602769, ISSN: 2692-8205.
Cabello AL, Wells K, Peng W, Feng HQ, Wang J, Meyer DF, Noroy C, Zhao ES, Zhang H, Li X, Chang H, Gomez G, Mao Y, Patrick KL, Watson RO, Russell WK, Yu A, Zhong J, Guo F, Li M, Zhou M, Qian X, Kobayashi KS, Song J, Panthee S, Mechref Y, Ficht TA, Qin QM, de Figueiredo P. Brucella-driven host N-glycome remodeling controls infection. Cell Host Microbe [print-electronic]. 2024 Apr 4/10/2024; 32(4): 588-605.e9-605.e9. PMID: 38531364, PII: S1931-3128(24)00083-0, DOI: 10.1016/j.chom.2024.03.003, ISSN: 1934-6069.
Scott HM, Smith MH, Coleman AK, Armijo KS, Chapman MJ, Apostalo SL, Wagner AR, Watson RO, Patrick KL. Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription. Cell Rep [print-electronic]. 2024 Mar 3/26/2024; 43(3): 113816. PMID: 38393946, PMCID: PMC11056844, PII: S2211-1247(24)00144-X, DOI: 10.1016/j.celrep.2024.113816, ISSN: 2211-1247.
Azam S, Armijo KS, Weindel CG, Chapman MJ, Devigne A, Nakagawa S, Hirose T, Carpenter S, Watson RO, Patrick KL. The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle. Proc Natl Acad Sci U S A [print-electronic]. 2024 Feb 2/27/2024; 121(9): e2312587121. PMID: 38381785, PMCID: PMC10907238, DOI: 10.1073/pnas.2312587121, ISSN: 1091-6490.
Ellzey LM, Patrick KL, Watson RO. Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection. Curr Opin Immunol [print-electronic]. 2023 Oct; 84: 102366. PMID: 37453340, PMCID: PMC10711692, PII: S0952-7915(23)00085-7, DOI: 10.1016/j.coi.2023.102366, ISSN: 1879-0372.
Weindel CG, Ellzey LM, Martinez EL, Watson RO, Patrick KL. Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis. Trends Cell Biol [print-electronic]. 2023 Sep; 33(9): 773-87. PMID: 37062616, PMCID: PMC10611448, PII: S0962-8924(23)00039-9, DOI: 10.1016/j.tcb.2023.02.007, ISSN: 1879-3088.
Scott HM, Smith MH, Coleman AK, Apostalo SL, Wagner AR, Watson RO, Patrick KL. Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7. BioRxiv. 2023 Jul 7/11/2023; PMID: 37503164, PMCID: PMC10369877, PII: 2023.05.09.540055, DOI: 10.1101/2023.05.09.540055, ISSN: 2692-8205.
Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS. Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens. PLoS Pathog. 2023 Jun; 19(6): e1011088. PMID: 37352334, PMCID: PMC10325092, PII: PPATHOGENS-D-22-02248, DOI: 10.1371/journal.ppat.1011088, ISSN: 1553-7374.
Wagner AR, Weindel CG, West KO, Scott HM, Watson RO, Patrick KL. SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX. Elife. 2022 Nov 11/21/2022; 11: PMID: 36409059, PMCID: PMC9718523, PII: 82244, DOI: 10.7554/eLife.82244, ISSN: 2050-084X.
Weindel CG, Martinez EL, Zhao X, Mabry CJ, Bell SL, Vail KJ, Coleman AK, VanPortfliet JJ, Zhao B, Wagner AR, Azam S, Scott HM, Li P, West AP, Karpac J, Patrick KL, Watson RO. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell [print-electronic]. 2022 Aug 8/18/2022; 185(17): 3214-3231.e23-3231.e23. PMID: 35907404, PMCID: PMC9531054, PII: S0092-8674(22)00790-5, DOI: 10.1016/j.cell.2022.06.038, ISSN: 1097-4172.
Vail KJ, da Silveira BP, Bell SL, Cohen ND, Bordin AI, Patrick KL, Watson RO. The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages. PLoS Pathog. 2021 Sep; 17(9): e1009888. PMID: 34473814, PMCID: PMC8443056, PII: PPATHOGENS-D-21-00708, DOI: 10.1371/journal.ppat.1009888, ISSN: 1553-7374.
Bell SL, Lopez KL, Cox JS, Patrick KL, Watson RO. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages. MBio [print-electronic]. 2021 Aug 8/31/2021; 12(4): e0187120. PMID: 34225486, PMCID: PMC8406326, DOI: 10.1128/mBio.01871-20, ISSN: 2150-7511.
Lei Y, Guerra Martinez C, Torres-Odio S, Bell SL, Birdwell CE, Bryant JD, Tong CW, Watson RO, West LC, West AP. Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Sci Adv [electronic-print]. 2021 May; 7(22): PMID: 34039599, PMCID: PMC8153723, PII: 7/22/eabe7548, DOI: 10.1126/sciadv.abe7548, ISSN: 2375-2548.
Ding S, Yang J, Feng X, Pandey A, Barhoumi R, Zhang D, Bell SL, Liu Y, da Costa LF, Rice-Ficht A, Watson RO, Patrick KL, Qin QM, Ficht TA, de Figueiredo P. Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes. IScience. 2021 Mar 3/19/2021; 24(3): 102192. PMID: 33718841, PMCID: PMC7920835, PII: S2589-0042(21)00160-7, DOI: 10.1016/j.isci.2021.102192, ISSN: 2589-0042.
Patrick KL, Watson RO. Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection. Infect Immun [electronic-print]. 2021 Mar 3/17/2021; 89(4): PMID: 33558322, PMCID: PMC8090963, PII: IAI.00687-20, DOI: 10.1128/IAI.00687-20, ISSN: 1098-5522.
Cossu D, Watson RO, Farina C. Editorial: A Microbial View of Central Nervous System Disorders: Interplay Between Microorganisms, Neuroinflammation and Behaviour [editorial]. Front Immunol. 2021; 12: 816227. PMID: 34975927, PMCID: PMC8716445, DOI: 10.3389/fimmu.2021.816227, ISSN: 1664-3224.
Wagner AR, Scott HM, West KO, Vail KJ, Fitzsimons TC, Coleman AK, Carter KE, Watson RO, Patrick KL. Global Transcriptomics Uncovers Distinct Contributions From Splicing Regulatory Proteins to the Macrophage Innate Immune Response. Front Immunol. 2021; 12: 656885. PMID: 34305890, PMCID: PMC8299563, DOI: 10.3389/fimmu.2021.656885, ISSN: 1664-3224.
Hoffpauir CT, Bell SL, West KO, Jing T, Wagner AR, Torres-Odio S, Cox JS, West AP, Li P, Patrick KL, Watson RO. TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection. J Immunol [print-electronic]. 2020 Jul 7/1/2020; 205(1): 153-67. PMID: 32404352, PMCID: PMC7313415, PII: jimmunol.1901511, DOI: 10.4049/jimmunol.1901511, ISSN: 1550-6606.
Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. Elife. 2020 Feb 2/14/2020; 9: PMID: 32057291, PMCID: PMC7159881, PII: 51071, DOI: 10.7554/eLife.51071, ISSN: 2050-084X.
West KO, Scott HM, Torres-Odio S, West AP, Patrick KL, Watson RO. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. Cell Rep. 2019 Nov 11/5/2019; 29(6): 1594-1609.e5-1609.e5. PMID: 31693898, PMCID: PMC6981299, PII: S2211-1247(19)31282-3, DOI: 10.1016/j.celrep.2019.09.078, ISSN: 2211-1247.
Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature [print-electronic]. 2019 May; 569(7758): 718-22. PMID: 31118511, PMCID: PMC6596994, PII: 10.1038/s41586-019-1228-x, DOI: 10.1038/s41586-019-1228-x, ISSN: 1476-4687.
Patrick KL, Bell SL, Weindel CG, Watson RO. Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat. Front Cell Infect Microbiol. 2019; 9: 138. PMID: 31192157, PMCID: PMC6546885, DOI: 10.3389/fcimb.2019.00138, ISSN: 2235-2988.
Patrick KL, Wojcechowskyj JA, Bell SL, Riba MN, Jing T, Talmage S, Xu P, Cabello AL, Xu J, Shales M, Jimenez-Morales D, Ficht TA, de Figueiredo P, Samuel JE, Li P, Krogan NJ, Watson RO. Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection. Cell Syst [print-electronic]. 2018 Sep 9/26/2018; 7(3): 323-338.e6-338.e6. PMID: 30077634, PMCID: PMC6160342, PII: S2405-4712(18)30277-1, DOI: 10.1016/j.cels.2018.06.010, ISSN: 2405-4712.
Patrick KL, Bell SL, Watson RO. For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses. J Mol Biol [print-electronic]. 2016 Aug 8/28/2016; 428(17): 3372-86. PMID: 27139640, PII: S0022-2836(16)30111-5, DOI: 10.1016/j.jmb.2016.04.030, ISSN: 1089-8638.
Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW, Cox JS. The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell Host Microbe [print-electronic]. 2015 Jun 6/10/2015; 17(6): 811-9. PMID: 26048136, PMCID: PMC4466081, DOI: 10.1016/j.chom.2015.05.004, ISSN: 1934-6069.
Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature [print-electronic]. 2013 Sep 9/26/2013; 501(7468): 512-6. PMID: 24005326, PMCID: PMC3886920, PII: nature12566, DOI: 10.1038/nature12566, ISSN: 1476-4687.
Watson RO, Manzanillo PS, Cox JS. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell. 2012 Aug 8/17/2012; 150(4): 803-15. PMID: 22901810, PMCID: PMC3708656, PII: S0092-8674(12)00884-7, DOI: 10.1016/j.cell.2012.06.040, ISSN: 1097-4172.
Strachan NJ, Watson RO, Novik V, Hofreuter D, Ogden ID, Galán JE. Sexual dimorphism in campylobacteriosis. Epidemiol Infect [print-electronic]. 2008 Nov; 136(11): 1492-5. PMID: 18062834, PMCID: PMC2870750, PII: S0950268807009934, DOI: 10.1017/S0950268807009934, ISSN: 0950-2688.
Watson RO, Galán JE. Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes. PLoS Pathog. 2008 Jan; 4(1): e14. PMID: 18225954, PMCID: PMC2323279, PII: 07-PLPA-RA-0409, DOI: 10.1371/journal.ppat.0040014, ISSN: 1553-7374.
Watson RO, Novik V, Hofreuter D, Lara-Tejero M, Galán JE. A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection. Infect Immun [print-electronic]. 2007 Apr; 75(4): 1994-2003. PMID: 17194808, PMCID: PMC1865720, PII: IAI.01216-06, DOI: 10.1128/IAI.01216-06, ISSN: 0019-9567.
Hofreuter D, Tsai J, Watson RO, Novik V, Altman B, Benitez M, Clark C, Perbost C, Jarvie T, Du L, Galán JE. Unique features of a highly pathogenic Campylobacter jejuni strain. Infect Immun. 2006 Aug; 74(8): 4694-707. PMID: 16861657, PMCID: PMC1539605, PII: 74/8/4694, DOI: 10.1128/IAI.00210-06, ISSN: 0019-9567.
Watson RO, Galán JE. Signal transduction in Campylobacter jejuni-induced cytokine production. Cell Microbiol. 2005 May; 7(5): 655-65. PMID: 15839895, PII: CMI498, DOI: 10.1111/j.1462-5822.2004.00498.x, ISSN: 1462-5814.
Chaussee MS, Sylva GL, Sturdevant DE, Smoot LM, Graham MR, Watson RO, Musser JM. Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes. Infect Immun. 2002 Feb; 70(2): 762-70. PMID: 11796609, PMCID: PMC127716, DOI: 10.1128/IAI.70.2.762-770.2002, ISSN: 0019-9567.
Murli S, Watson RO, Galán JE. Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells. Cell Microbiol. 2001 Dec; 3(12): 795-810. PMID: 11736992, PII: 158, DOI: 10.1046/j.1462-5822.2001.00158.x, ISSN: 1462-5814.
Chaussee MS, Watson RO, Smoot JC, Musser JM. Identification of Rgg-regulated exoproteins of Streptococcus pyogenes. Infect Immun. 2001 Feb; 69(2): 822-31. PMID: 11159974, PMCID: PMC97958, DOI: 10.1128/IAI.69.2.822-831.2001, ISSN: 0019-9567.