Faculty Appointments
Assistant Professor of Biochemistry
Education
Ph.D., Molecular Genetis, Georgia Institute of Technology, Atlanta, Georgia
Research Keywords
Biochemistry, Biological Sciences, Computational Biology, Computational Genetics, Gene Therapy, Microbiology, Molecular Biology, Molecular Genetics, RNA Biology, Evolution
Publications
Keller MR, McKinney MG, Sen AK, Guagliardo FG, Hellwarth EB, Islam KN, Kaplan NA, Gibbons WJ, Kemmerly GE, Meers C, Wang X, Jones JA. Psilocybin biosynthesis enhancement through gene source optimization. Metab Eng [print-electronic]. 2025 Sep; 91: 119-29. PMID: 40250599, PII: S1096-7176(25)00067-9, DOI: 10.1016/j.ymben.2025.04.003, ISSN: 1096-7184.
Hoffmann FT, Wiegand T, Palmieri AI, Glass-Klaiber J, Xiao R, Tang S, Le H, Meers C, Lampe GD, Chang L, Sternberg SH. Exapted CRISPR-Cas12f homologs drive RNA-guided transcription. BioRxiv. 2025 Jun 6/10/2025; PMID: 40661409, PMCID: PMC12259090, PII: 2025.06.10.658865, DOI: 10.1101/2025.06.10.658865, ISSN: 2692-8205.
Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH. Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. Nat Microbiol [print-electronic]. 2025 Jan; 10(1): 20-7. PMID: 39747689, PMCID: PMC11930352, PII: 10.1038/s41564-024-01889-2, DOI: 10.1038/s41564-024-01889-2, ISSN: 2058-5276.
Jeon Y, Lu Y, Ferrari MM, Channagiri T, Xu P, Meers C, Zhang Y, Balachander S, Park VS, Marsili S, Pursell ZF, Jonoska N, Storici F. RNA-mediated double-strand break repair by end-joining mechanisms. Nat Commun. 2024 Sep 9/11/2024; 15(1): 7935. PMID: 39261460, PMCID: PMC11390984, PII: 10.1038/s41467-024-51457-9, DOI: 10.1038/s41467-024-51457-9, ISSN: 2041-1723.
Žedaveinyte R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH. Antagonistic conflict between transposon-encoded introns and guide RNAs. Science [print-electronic]. 2024 Jul 7/12/2024; 385(6705): eadm8189. PMID: 38991068, PMCID: PMC11758368, DOI: 10.1126/science.adm8189, ISSN: 1095-9203.
Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH. TnpB homologues exapted from transposons are RNA-guided transcription factors. Nature [print-electronic]. 2024 Jul; 631(8020): 439-48. PMID: 38926585, PMCID: PMC11702177, PII: 10.1038/s41586-024-07598-4, DOI: 10.1038/s41586-024-07598-4, ISSN: 1476-4687.
Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH. Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. BioRxiv. 2024 Jun 6/21/2024; PMID: 38948817, PMCID: PMC11213020, PII: 2024.06.21.599552, DOI: 10.1101/2024.06.21.599552, ISSN: 2692-8205.
Kundnani DL, Yang T, Gombolay AL, Mukherjee K, Newnam G, Meers C, Verma I, Chhatlani K, Mehta ZH, Mouawad C, Storici F. Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome ortholog mutants of Saccharomyces cerevisiae. IScience. 2024 Jun 6/21/2024; 27(6): 110012. PMID: 38868188, PMCID: PMC11166700, PII: S2589-0042(24)01237-9, DOI: 10.1016/j.isci.2024.110012, ISSN: 2589-0042.
Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH. Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases. BioRxiv. 2023 Nov 11/30/2023; PMID: 38076855, PMCID: PMC10705468, PII: 2023.11.30.569447, DOI: 10.1101/2023.11.30.569447, ISSN: 2692-8205.
Žedaveinyte R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH. Antagonistic conflict between transposon-encoded introns and guide RNAs. BioRxiv. 2023 Nov 11/20/2023; PMID: 38045383, PMCID: PMC10690162, PII: 2023.11.20.567912, DOI: 10.1101/2023.11.20.567912, ISSN: 2692-8205.
Kundnani DL, Yang T, Gombolay AL, Mukherjee K, Newnam G, Meers C, Mehta ZH, Mouawad C, Storici F. Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of Saccharomyces cerevisiae. BioRxiv. 2023 Oct 10/2/2023; PMID: 37873120, PMCID: PMC10592897, PII: 2023.10.02.560505, DOI: 10.1101/2023.10.02.560505, ISSN: 2692-8205.
Meers C, Le HC, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Tang S, Sternberg SH. Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Nature [print-electronic]. 2023 Oct; 622(7984): 863-71. PMID: 37758954, PMCID: PMC11758364, PII: 10.1038/s41586-023-06597-1, DOI: 10.1038/s41586-023-06597-1, ISSN: 1476-4687.
Meers C, Le H, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Sternberg SH. Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance. BioRxiv. 2023 Mar 3/29/2023; PMID: 36993599, PMCID: PMC10055086, PII: 2023.03.14.532601, DOI: 10.1101/2023.03.14.532601, ISSN: 2692-8205.
Hoffmann FT, Wiegand T, Palmieri AI, Glass-Klaiber J, Xiao R, Tang S, Le H, Meers C, Lampe GD, Chang L, Sternberg SH. Exapted CRISPR-Cas12f homologs drive RNA-guided transcription. BioRxiv. 2025 Jun 6/10/2025; PMID: 40661409, PMCID: PMC12259090, PII: 2025.06.10.658865, DOI: 10.1101/2025.06.10.658865, ISSN: 2692-8205.
Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH. Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. Nat Microbiol [print-electronic]. 2025 Jan; 10(1): 20-7. PMID: 39747689, PMCID: PMC11930352, PII: 10.1038/s41564-024-01889-2, DOI: 10.1038/s41564-024-01889-2, ISSN: 2058-5276.
Jeon Y, Lu Y, Ferrari MM, Channagiri T, Xu P, Meers C, Zhang Y, Balachander S, Park VS, Marsili S, Pursell ZF, Jonoska N, Storici F. RNA-mediated double-strand break repair by end-joining mechanisms. Nat Commun. 2024 Sep 9/11/2024; 15(1): 7935. PMID: 39261460, PMCID: PMC11390984, PII: 10.1038/s41467-024-51457-9, DOI: 10.1038/s41467-024-51457-9, ISSN: 2041-1723.
Žedaveinyte R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH. Antagonistic conflict between transposon-encoded introns and guide RNAs. Science [print-electronic]. 2024 Jul 7/12/2024; 385(6705): eadm8189. PMID: 38991068, PMCID: PMC11758368, DOI: 10.1126/science.adm8189, ISSN: 1095-9203.
Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH. TnpB homologues exapted from transposons are RNA-guided transcription factors. Nature [print-electronic]. 2024 Jul; 631(8020): 439-48. PMID: 38926585, PMCID: PMC11702177, PII: 10.1038/s41586-024-07598-4, DOI: 10.1038/s41586-024-07598-4, ISSN: 1476-4687.
Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH. Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. BioRxiv. 2024 Jun 6/21/2024; PMID: 38948817, PMCID: PMC11213020, PII: 2024.06.21.599552, DOI: 10.1101/2024.06.21.599552, ISSN: 2692-8205.
Kundnani DL, Yang T, Gombolay AL, Mukherjee K, Newnam G, Meers C, Verma I, Chhatlani K, Mehta ZH, Mouawad C, Storici F. Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome ortholog mutants of Saccharomyces cerevisiae. IScience. 2024 Jun 6/21/2024; 27(6): 110012. PMID: 38868188, PMCID: PMC11166700, PII: S2589-0042(24)01237-9, DOI: 10.1016/j.isci.2024.110012, ISSN: 2589-0042.
Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH. Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases. BioRxiv. 2023 Nov 11/30/2023; PMID: 38076855, PMCID: PMC10705468, PII: 2023.11.30.569447, DOI: 10.1101/2023.11.30.569447, ISSN: 2692-8205.
Žedaveinyte R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH. Antagonistic conflict between transposon-encoded introns and guide RNAs. BioRxiv. 2023 Nov 11/20/2023; PMID: 38045383, PMCID: PMC10690162, PII: 2023.11.20.567912, DOI: 10.1101/2023.11.20.567912, ISSN: 2692-8205.
Kundnani DL, Yang T, Gombolay AL, Mukherjee K, Newnam G, Meers C, Mehta ZH, Mouawad C, Storici F. Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of Saccharomyces cerevisiae. BioRxiv. 2023 Oct 10/2/2023; PMID: 37873120, PMCID: PMC10592897, PII: 2023.10.02.560505, DOI: 10.1101/2023.10.02.560505, ISSN: 2692-8205.
Meers C, Le HC, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Tang S, Sternberg SH. Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Nature [print-electronic]. 2023 Oct; 622(7984): 863-71. PMID: 37758954, PMCID: PMC11758364, PII: 10.1038/s41586-023-06597-1, DOI: 10.1038/s41586-023-06597-1, ISSN: 1476-4687.
Meers C, Le H, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Sternberg SH. Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance. BioRxiv. 2023 Mar 3/29/2023; PMID: 36993599, PMCID: PMC10055086, PII: 2023.03.14.532601, DOI: 10.1101/2023.03.14.532601, ISSN: 2692-8205.