Faculty Appointments
Associate Professor of Biochemistry and Cancer Biology at Meharry Medical College
Adjunct Associate Professor of Surgery
Education
Ph.D., Surgery, Karolinska Institutet, Stockholm, SwedenLicentiate Diploma, Surgery, Karolinska Institutet, Stockholm, SwedenM.D., Medicine, Kharkov Medical Institute, Kharkov, Ukraine
Office Address
Vanderbilt University
Department of Surgery, Colon & Rectal Surgery
D-5248 MCN
Nashville, TN
Department of Surgery, Colon & Rectal Surgery
D-5248 MCN
Nashville, TN
Research Description
The research is focused on understanding the etiopathogenesis and pathophysiology of colorectal inflammatory bowel disease (cIBD), with particular emphasis on diagnostic methodologies and the surgical management of ulcerative colitis (UC), specifically the physiology of restorative proctocolectomy and ileal pouch-anal anastomosis (RPC-IPAA). Current research efforts are directed toward developing strategic methodologies based on matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), proteomics, and recombinant single-chain antibodies to identify peptides that can delineate disease subtypes and facilitate the development of discriminatory diagnostic tools for cIBD.
Patients with cIBD are susceptible to long-term complications related to both the disease itself and the medications used to treat it. In some cases, definitive treatment may require surgical removal of the entire colon. However, patients undergoing RPC-IPAA may subsequently develop complications such as pouchitis, cuffitis, dysplasia, strictures, and/or fistulae. The reasons why these complications affect patients with cIBD differently following RPC-IPAA have not been fully elucidated. Currently, there are no established preoperative predictors of these complications. The ability to predict such outcomes could facilitate the implementation of prophylactic measures and help prevent adverse pathological outcomes.
Therefore, future studies will focus on further elucidation and validation of the monoclonal antibodies (mAbs), and recombinant single-chain antibodies (scFvs) in larger patient cohorts to identify and characterize associated biomarkers. These biomarkers may ultimately be used to:
*Clarify proteomic differences between sporadic dysplasia and colitis-associated dysplasia.
*Predict the clinical course of indeterminate colitis (IC) and its progression toward definitive authentic UC or CC.
*Predict which patients with UC or CC are likely to develop colitis-associated colorectal cancer.
*Predict which patients with CC are likely to develop strictures and/or fistulae.
*Predict which patients with UC are likely to develop pouchitis and/or cuffitis following RPC-IPAA surgery.
*Predict which patients with UC are likely to develop de novo Crohn’s disease following RPC-IPAA surgery.
*Pre-IPAA risk stratification for safe pouch surgery (RPC-IPAA)
*Provide objective evidence to guide colorectal surgeons and inform patient selection before irreversible procedures such as IPAA..
Patients with cIBD are susceptible to long-term complications related to both the disease itself and the medications used to treat it. In some cases, definitive treatment may require surgical removal of the entire colon. However, patients undergoing RPC-IPAA may subsequently develop complications such as pouchitis, cuffitis, dysplasia, strictures, and/or fistulae. The reasons why these complications affect patients with cIBD differently following RPC-IPAA have not been fully elucidated. Currently, there are no established preoperative predictors of these complications. The ability to predict such outcomes could facilitate the implementation of prophylactic measures and help prevent adverse pathological outcomes.
Therefore, future studies will focus on further elucidation and validation of the monoclonal antibodies (mAbs), and recombinant single-chain antibodies (scFvs) in larger patient cohorts to identify and characterize associated biomarkers. These biomarkers may ultimately be used to:
*Clarify proteomic differences between sporadic dysplasia and colitis-associated dysplasia.
*Predict the clinical course of indeterminate colitis (IC) and its progression toward definitive authentic UC or CC.
*Predict which patients with UC or CC are likely to develop colitis-associated colorectal cancer.
*Predict which patients with CC are likely to develop strictures and/or fistulae.
*Predict which patients with UC are likely to develop pouchitis and/or cuffitis following RPC-IPAA surgery.
*Predict which patients with UC are likely to develop de novo Crohn’s disease following RPC-IPAA surgery.
*Pre-IPAA risk stratification for safe pouch surgery (RPC-IPAA)
*Provide objective evidence to guide colorectal surgeons and inform patient selection before irreversible procedures such as IPAA..
Clinical Description
Colorectal inflammatory bowel disease (cIBD) affects millions of people in the United States, and its incidence and prevalence are increasing worldwide, making it an emerging global health concern. Currently, no curative pharmacological therapy exists for cIBD, which can result in significant long-term morbidity. cIBD includes ulcerative colitis (UC) and Crohn’s disease (CD), two highly heterogeneous, chronic, relapsing-and-remitting disorders of the gastrointestinal (GI) tract.
North America, including Canada, has among the highest rates of cIBD worldwide. Timely diagnosis is central to optimal cIBD care because diagnostic ambiguity and delays are associated with adverse disease outcomes. Although the interval between symptom onset and referral by a primary care physician to a gastroenterologist is by far the greatest contributor to the overall time to diagnosis, delayed and/or incorrect diagnosis remains a common and serious unmet challenge in cIBD.
Current diagnostic methods for cIBD remain imperfect and have changed little over the past 60 years. Up to 15% of cIBD cases are classified as indeterminate colitis (IC) when established criteria for UC and Crohn’s colitis (CC) are inconclusive. In an additional 15% of cIBD cases, definitive evidence of CC is not apparent before colectomy. Thus, approximately 30% of patients with cIBD may not receive an accurate diagnosis in a timely manner.
Much of this diagnostic uncertainty arises from overlapping clinical, endoscopic, radiologic, and histopathologic features that can make CC resemble UC. Typically, intestinal wall thickening in CC is segmental, whereas inflammation in UC is generally continuous. UC primarily causes inflammation and ulceration of the mucosal and, to a lesser extent, submucosal layers of the colon and rectum. In contrast, CC may cause deeper, transmural inflammation involving all four layers of the intestinal wall and may present with skip lesions. CC can also affect adjacent organs through fistula formation. Unfortunately, during the prodromal stages of the disease, these distinguishing features may be absent or difficult to detect in approximately 30% of cases, further complicating diagnostic classification and treatment decisions.
The standard surgical treatment for medically refractory UC is RPC-IPAA, commonly referred to as pouch surgery. Crohn’s colitis is a relative contraindication to RPC-IPAA because of the higher risk of pouch-related complications and failure, even among highly selected patients. Therefore, elimination of IC to accurate authentic UC or CC is clinically important. A low-risk, minimally invasive diagnostic screening approach could facilitate accurate and timely disease classification, enable appropriate treatment selection, and ultimately improve health outcomes and quality of life while reducing medical complications, unnecessary surgeries, and healthcare costs.
North America, including Canada, has among the highest rates of cIBD worldwide. Timely diagnosis is central to optimal cIBD care because diagnostic ambiguity and delays are associated with adverse disease outcomes. Although the interval between symptom onset and referral by a primary care physician to a gastroenterologist is by far the greatest contributor to the overall time to diagnosis, delayed and/or incorrect diagnosis remains a common and serious unmet challenge in cIBD.
Current diagnostic methods for cIBD remain imperfect and have changed little over the past 60 years. Up to 15% of cIBD cases are classified as indeterminate colitis (IC) when established criteria for UC and Crohn’s colitis (CC) are inconclusive. In an additional 15% of cIBD cases, definitive evidence of CC is not apparent before colectomy. Thus, approximately 30% of patients with cIBD may not receive an accurate diagnosis in a timely manner.
Much of this diagnostic uncertainty arises from overlapping clinical, endoscopic, radiologic, and histopathologic features that can make CC resemble UC. Typically, intestinal wall thickening in CC is segmental, whereas inflammation in UC is generally continuous. UC primarily causes inflammation and ulceration of the mucosal and, to a lesser extent, submucosal layers of the colon and rectum. In contrast, CC may cause deeper, transmural inflammation involving all four layers of the intestinal wall and may present with skip lesions. CC can also affect adjacent organs through fistula formation. Unfortunately, during the prodromal stages of the disease, these distinguishing features may be absent or difficult to detect in approximately 30% of cases, further complicating diagnostic classification and treatment decisions.
The standard surgical treatment for medically refractory UC is RPC-IPAA, commonly referred to as pouch surgery. Crohn’s colitis is a relative contraindication to RPC-IPAA because of the higher risk of pouch-related complications and failure, even among highly selected patients. Therefore, elimination of IC to accurate authentic UC or CC is clinically important. A low-risk, minimally invasive diagnostic screening approach could facilitate accurate and timely disease classification, enable appropriate treatment selection, and ultimately improve health outcomes and quality of life while reducing medical complications, unnecessary surgeries, and healthcare costs.
Research Keywords
One of the greatest advances in colorectal surgery over the past four decades has been the development of RPC-IPAA for patients suffering from UC and familial adenomatous polyposis (FAP). The development and refinement of pelvic pouch surgery have made it possible to completely excise the diseased colon while maintaining transanal fecal continence. The success of RPC-IPAA is largely dependent on careful patient selection combined with meticulous surgical technique. RPC-IPAA is now the standard surgical procedure for the treatment of patients with UC and FAP.
When this procedure first became the standard of care, little was known about the metabolic consequences of the operation. We subsequently initiated several prospective studies investigating surgical complications, pouch function, the consequences of inflammation of the pouch (pouchitis) and residual rectal cuff (cuffitis), emerging trends in ileal reservoir construction, blood variable works and health-related quality-of-life (QoL) outcomes. We also developed several laboratory tests to detect possible metabolic effects of RPC-IPAA physiology (see publications).
Patients report high levels of QoL and satisfaction, and functional outcomes remain excellent, even after 20 years of pouch function (PubMed ID: 16437210). The critical challenge we continue to face is establishing an accurate diagnosis in patients with cIBD, especially at pre-IPAA stratification. An accurate diagnosis before initiating medical therapy or performing colectomy is of paramount importance for evidence-based, personalized medical therapy, surgical decision-making, and prognosis. Accurate diagnosis is also essential for distinguishing cIBD subtypes through non-invasive, simpler, more accurate, and faster screening methods.
Misdiagnosis and inappropriate treatment courses can result in morbidity from unnecessary or inappropriate surgical procedures and increased healthcare costs. This underscores the need for continued research aimed at more accurately delineating cIBD subtypes and establishing reliable diagnostic approaches.
Clinical Research Keywords
Colorectal Sciences (CS), Colorectal Inflammatory Bowel Disease (cIBD), Ulcerative colitis (UC), Crohn's colitis (CC), Indeterminate colitis (IC), Familial adenomatous polyposis (FAP), Gastrointestinal Endoscopic Medicine, Molecular Diagnostics, Colonic Ileal Metaplasia, Precision Medicine, DEFA5, HD5, Clone 1A8, Clone 4F5, Hba, Hbß, MALDI MS, mAbs, scFvs, Physiology of RPC-IPAA.
Publications
Sakwe AM, M'Koma AE, et al. Beyond Diagnostic Labels: Why Pre-IPAA Biomarker Stratification Optimizes Surgical Decision-Making in Colorectal Inflammatory Bowel Disease. JS. c2026 Sep 9/15/2026.
M'Koma AE, Johnson SM. Colorectal Inflammatory Bowel Disease in Sub-Saharan Africa: Diagnostic Challenges and Systemic Care Constraints. Am Surg. 2026 Aug 8/17/2026; 31348261471491. PMID: 42608668, DOI: 10.1177/00031348261471491, ISSN: 1555-9823.
M'Koma AE, et al. Correction: Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis. J Clin Med. 2026 Feb 2/14/2026; 15(4): 1519. Communication: Special Issue. PMID: 41375691.
M'Koma AE. Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis. J Clin Med. c2025 Nov 11/26/2025; (14): 8390. Communication , Special Issue. PMID: 41375691.
Thangaiya T, Shanker A, Ballard BR, M'Koma AE. Structural and Epitope Characterization of Anti-DEFA5 Monoclonal Antibodies for Diagnostics in Inflammatory Bowel Disease. Int J Biol Macromol. c2025 Oct 10/7/2025; 330: 148024. PMID: 41067337.
M'Koma AE. Methods for diagnosing and treating inflammatory bowel disease (IBD). Nashville, Tennessee (United States): The United States Patent and Trademark Office (USPTO); c2025 Feb 2/4/2025.The patent details further methodology for the diagnosis and treatment of IBD. It is an extension of research to identifying molecular differentiation of IBD subtypes.
Thangaiyan R, Sakwe AM, Hawkins AT, Washington MK, Ballard BR, Izban MG, Chirwa SS, Hildreth JEK, Shanker A, Blum DL, M'Koma AE. Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues. Inflamm Res. 2025 Jan 1/30/2025; 74(1): 30. PMID: 39883179.
Featured on the Cover Story of the World Journal Gastrointestinal Endoscopy, 2025. World Journal of Gastrointestinal Endoscopy. 2025 Jan 1/16/2025; 17(1) Sect. Latest Archive, 2025:100472 (col. Journal WJGE).
M'Koma AE, Sakwe AM. Targeted HD5 antibody and assay methods for diagnosing and treating inflammatory bowel disease. Washongton DC (United States): United States Patent and Trademark Office (USPTO); 2024 Dec 12/24/2024.PII: 12174200.
Thangaiyan R, Sakwe AM, Hawkins AT, Washington MK, Ballard BR, Izban MG, Chirwa SS, Hildreth JEK, Shanker A, Blum DL, M'Koma AE. Anti-DEFA5 Monoclonal Antibody Clones 1A8 and 4F5 Immunoreactive Bioassay for Diagnosing Inflammatory Bowel Disease. Inflamm Res. 2024 Aug 8/29/2024; 1-25. PMID: 39257990.
Hajri TH, Gharib MG, Fungwe FT, M'Koma AE. Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance. Am J Physiol Heart Circ Physiol. 2024 May 5/24/2024; PMID: 38787383.
Breaux WA, Bragg MA, M'Koma AE. Ubiquitous Colonic Ileal Metaplasia Consistent with the Diagnosis of Crohn's Colitis among Indeterminate Colitis Cohorts. Med Res Arch. 2023 Aug 8/1/2023; 11(8): 4188. PMID: 37854669.
Johnson JC, Geesala R, Zhang K, Lin YM, M'Koma AE, Shi XZ. Smooth muscle dysfunction in the pre-inflammation site in stenotic Crohn's-like colitis: implication of mechanical stress in bowel dysfunction in gut inflammation. Front Physiol. 2023 Jul 7/14/2023; 14(14): 1215900. PMID: 37520831.
Bragg MA, Breaux WA, M'Koma AE. Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational and Transformational Risks Posed by Exogenous Free Hemoglobin Alpha Chain, A By-Product of Extravasated Erythrocyte Macrophage Erythrophagocytosis. Medicina (Kaunas). 2023 Jul 7/1/2023; 59(7): 1-19. PMID: 37476546.
M'Koma AE, Ware JN, Nabaweesi RK, Chirwa SS. Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood. Med Res Arch. 2023 Jun 6/1/2023; 6(11): 3784.
M'Koma AE. Inflammatory Bowel Disease: Clinical Diagnosis and Pharmaceutical Management. Med Res Arch. c2023 Jan 1/31/2023; 11(1): PMID: 37089816.
M'Koma AE. Amosy M'Koma Featured on the Cover Story of World Journal of Gastrointestinal Endoscopy. World J Gastrointest Endosc (WJGE). c2023 Jan 1/16/2023; 15(1): 1. PII: 1948-5190, PII: doi: 10.4253/wjge.v15.i1.10, ISSN: ISSN 1948-5190 (online).
Featured on the Cover Story of World Journal of Gastrointestinal Endoscopy. 2023. WJGE (World Journals-Baishideng). 2023 Jan 1/1/2023.
M'Koma AE. Methods for Diagnosing and Treating Inflammatory Bowel Disease. Nashville (United States): United States Patent and Trademark Office (USPTO); 2022 Aug 8/30/2022.PII: 11427852. *Publication of US11427852B2 *Granted on 2022-08-30 *Status - Active *Adjusted expiration date - 2038-04-14.
M'Koma AE. Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview. Medicina. 2022 Apr 4/21/2022; 58(5): 567-80. PMID: 35629984.
Geesala R, Lin YM, Zhang K, M'Koma AE, Cohn S, Shi XZ. Novel Insights into the mechanism of action of exclusive enteral nutrition in Crohn's disease: Pre-clinical study in a rodent model of Crohn's-like colitis. Inflammatory Bowel Disease (IBD). c2022 Jan 1/22/2022; 28(Supplemental 1): S27-S28.
M'Koma AE, Sakwe AM. Targeted HD5 Antibody and Assay Methods for Diagnosing and Treating Inflammatory Bowel Disease. Nashville (United States): US Patent App. 16/622,269; 2021 Sep 9/9/2021.ISSN: WO2018237064A1, ISSN: United States Patent Application 20210278417.
Lin You-Min, Qiu Suimmin, M'Koma Amosy E, Powell Don W, Cohn Steven, Shi Xuan-Zheng P. Sa130 mechanical stress plays a critical role in intestinal fibrosis and smooth muscle hyperplasia in a rodent model of Crohn's disease. Gastroenterology. 2021 May 5/1/2021; 160(6): S-431.
M'Koma AE. The diagnostic potential of human alpha defensin 5 in inflammatory bowel disease. Dis Colon Rectum. c2021 May 5/1/2021; 64(5).
Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Hui N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 2021 Mar; 16(3): e0246393. PMID: 33690604, PMCID: PMC7942995, PII: PONE-D-20-32369, DOI: 10.1371/journal.pone.0246393, ISSN: 1932-6203.
Herman AM, Hawkins AT, James SD, Ballard BR, M'Koma AE. Inflammatory Bowel Disease On-Line Web-Based Guide to Health Professionals and Patients in Developing and African Nations. JJGH. 2020 Mar 3/24/2020; 3(2): 1-11.
James SD, Hawkins AT, Um JW, Ballard BR, Smoot DT, M'Koma AE. The MYTHS of De novo Crohn's Disease After Restorative Proctocolectomy with Ileal Pouch-anal Anastomosis for Ulcerative Colitis. JJGH. 2020 Mar 3/11/2020; 3(2): 1-10.
Ballard BR, M'Koma AE. Paneth Cell Physiology and Pathophysiology in Inflammatory Bowel Disease. Digestive System Diseases. Stem Cell Biology and Regenerative Medicine. 1. Switzerland: Springer; 2019 Mar.180 p. ISBN-13: 978-3-030-11965-2.. Available from: https://link.springer.com/chapter/10.1007/978-3-030-11965-2_9.
M'Koma AE. The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview. Gastrointest Disord. 2018 Oct 10/18/2018; 1(1): 75-105. DOI: https://doi.org/10.3390/gidisord1010007.
James SD, Hawkins AT, M'Koma AE. Adenocarcinoma at the Ileostomy Site After a Proctocolectomy for Ulcerative Colitis and/or Familial Adenomatous Polyposis: An Overview. Ostomy Wound Manage. 2018 Jul 7/31/2018; 64(6): 30-40. PMID: 30059346.
Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Clin Med Insights Gastroenetrol. 2017 Dec 12/13/2017; 10: 1-6. PMID: 29276421.
Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017 Dec 12/6/2017; PMID: 29211779.
M'Koma AE. Editorial Policies and Skills to Solving Diagnostic Delay in Inflammatory Bowel Disease. Gen Surg Rep. 2017 Sep 9/22/2017; 1(1): 1-2.
Williams AD, korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human Alpha Defensin-5 is a Candidate Biomarker to Delineate Inflammatory Bowel Disease. PLoS One. 2017 Aug 8/17/2017; 12(8): e0179710. PMID: 28817680.
Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Clin Med Insights Gastroenterol. 2017; 10: 1179552217746692. PMID: 29276421, PMCID: PMC5734426, PII: 10.1177_1179552217746692, DOI: 10.1177/1179552217746692, ISSN: 1179-5522.
World Journal of Surgical Procedures. Amosy M'Koma Featured on the Cover Story of World Journal of Surgical Procedures. Pleasanton (United States): Baishideng Publishing Group Inc.; 2015 Mar 3/28/2015.1-176 p. ISSN: 2219-2832.
M'Koma AE. Diagnosis of Inflammatory Bowel Disease: Potential Role of Molecular Biometrics. In: World Clinical Inflammatory Bowel Disease. 1. Pleasanton (United States): Baishideng Publishing Group Inc; 2015 Feb 2/8/2015.E-Book Chapter 1-1215; p. 1204-15. ISBN-13: 978-0-9914430-5-5.
Vaiopoulou A, Gazouli M, Papadopoulou A, Anagnostopoulos AK, Karamanolis G, Theodoropoulos GE, M'Koma A, Tsangaris GT.. Serum Protein Profiling of Adults And Children With Crohn's Disease. J Peduiatr Gastroenterol Nutr. 2015; 60(1): 42-7. PMID: 25250685.
Korolkova OY, Myers JN, Pellom ST, Wang L, M'Koma AE. Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides. Clin Med Insights Gastroenterol. 2015; (8): 29-44. PMID: 26078592.
Ballard BR, M'Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis. World J Gastrointest Endosc. 2015; 7(7): 670-4. PMID: 26140094.
Myers JN, Schaffer MW, Korolkova OY, Williams AD, Gangula PR, M'Koma AE. Implications of the Colonic Deposition of Free Hemoglobin-a Chain: A Previously Unknown Tissue By-product in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2014; 20(9): 1530-47. PMID: 25078150.
M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg. 2014; 6(11): 208-119. PMID: 25429322.
Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013 Aug; 7(7-8): 541-9. PMID: 23382084, PMCID: PMC3737405, DOI: 10.1002/prca.201200107, ISSN: 1862-8354.
Smith JC, Schaeffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas after Prophylactic Surgery for Familial Adenomatous Polyposis. J Cancer Ther. 2013; 4(1): 260-70. PMID: 23875116.
M'Koma AE. Inflammatory Bowel Disease: An Expanding Global Health Problem. Clin Med Insights Gastroenterol. 2013; 6: 33-47. PMID: 24833941.
M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment After Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2): PMID: 24817992.
M'Koma AE. Letter to the Editor, Advances in Enzyme Research. Adv Enzyme Res. 2013; 1(4): 77-8. PMID: 25664328.
M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2): PMID: 24817992, PMCID: PMC4012278, ISSN: 1941-8213.
Um JW, M'Koma AE. Dysplasie und Adenokarzinome im Ileum-Pouch nach restaurativer Proktokolektomie wegen Colitis ulcerosa. Coloproctocology. 2011; 33: 273-82. ISSN: 1615-6730, ISSN: 0174-2442.
M'Koma AE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Wise PE, Caplioli RM.. Proteomic Profiling of Mucosal and Submucosal Colonic Tissues Yields Protein Signatures that Differentiate the Inflammatory Colitides. Inflamm Bowel Dis. 2011; 17((4)): 875-83. PMID: 20806340.
Um JW, M'Koma AE. Pouch-related dysplasia and adenocarcinoma following restorative proctocolectomy for ulcerative colitis. Tech Coloproctol. 2011; 15((1)): 7-16. PMID: 21287223.
M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2011; 26((5)): 533-52. PMID: 21311893.
Amosy M'Koma. Biochemical Laboratory Data Following Restorative Proctocolectomy:Observations on Essential Biochemical Data Profile in Connection with Restorative Proctocolectomy in Humans. First. Berlin (Germany): Lambert Academic Publishing AG & Co.; 2010 Apr 4/10/2010.74 p. ISBN-13: 978-3-8383-2057-1, ISBN-13: ISBN-10: 3838320573.. Available from: https://www.amazon.com/Biochemical-Laboratory-Following-Restorative-Proctocolectomy/dp/3838320573.
M'Koma AE, Wise PE, Schwartz DA, Muldoon RL, Herline AJ.. Prevalence and Outcome of Anemia after Restorative Proctocolectomy. Clinical Literature Review. Dis Colon Rectum. 2009; 52((4)): 726-36. PMID: 19404082.
Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith Jr JA, Clark PE, Bhowmick NE. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res. 2008; 14((23)): 7790-7. PMID: 19047106.
M'Koma AE, Wise PE, Muldoon RL, Schwartz DA, Washington MK, Herline AJ. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. Int J Colorectal Dis. 2007 Oct; 22(10): 1143-63. PMID: 17576578, DOI: 10.1007/s00384-007-0331-x, ISSN: 0179-1958.
M'Koma AE, Longo WE. Postoperative liver enzyme abnormalities are related to staged restorative proctocolectomy. Int J Colorectal Dis. 2007 Mar; 22(3): 283-8. PMID: 16583192, DOI: 10.1007/s00384-006-0130-9, ISSN: 0179-1958.
M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem. Biophys. Res. Commun. 2007 Feb 2/16/2007; 353(3): 829-34. PMID: 17194448, PMCID: PMC2562600, PII: S0006-291X(06)02787-2, DOI: 10.1016/j.bbrc.2006.12.111, ISSN: 0006-291X.
M'Koma AE. Serum biochemical evaluation of patients with functional pouches ten to 20 years after restorative proctocolectomy. Int J Colorectal Dis. 2006 Oct; 21(7): 711-20. PMID: 16437210, DOI: 10.1007/s00384-005-0076-3, ISSN: 0179-1958.
M'Koma AE, et al. Advances and challenges in the diagnostic accuracy for surgical management of inflammatory bowel disease: Potential role of molecular biometrics. J Clin Cell Immunol. c2004 Sep 9/29/2004.
Swedish Government. Swedish Ministry of Heath. First. Stockholm (Sweden): Fritzes Offentliga Publikationer (SU 2004); 2004.240 p. ISBN-13: 91-38-22080-6.. Available from: http://www.regeringen.se/sb/d/189/a/3004.
M'Koma AE. Observations On Essential Biochemical Data Profile In Connection With Restorative Proctocolectomy In Humans: Vitamin B12 and Fat Absorption Cited. First. Stockholm (Sweden): Karolinska Universiry Press; 2001 Nov 11/8/2001.126 p. ISBN-13: 91-7349-007-5.. Available from: https://openarchive.ki.se/articles/thesis/Observations_on_essential_biochemical_data_profile_in_connection_with_restorative_proctocolectomy_in_humans_vitamin_B12_and_fat_absorption_cited/26908285?file=48950818.
M'Koma AE, Lindquist K, Liljeqvist L. Observations in the blood lipid profile in patients undergoing restorative proctocolectomy. Int. J. Surg. Investig. 2000; 2(3): 227-35. PMID: 12678523, ISSN: 1028-5229.
M'Koma AE, Lindquist K, Liljeqvist L. A study of plasma immunoglobulins profile in connection with restorative proctocolectomy. Int. J. Surg. Investig. 2000; 2(2): 125-31. PMID: 12678510, ISSN: 1028-5229.
M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels: a prospective study. Dis. Colon Rectum. 1999 Mar; 42(3): 398-402. PMID: 10223764, ISSN: 0012-3706.
M'Koma AE. Observations on biochemical data in connection with restorative proctocolectomy: an analysis with specific reference to lipoproteins and gastric acids. First. Stockholm (Sweden): Karolinsks University Press; 1999.74 p. ISBN-13: 91-7349-0091.. Available from: http://libris.kb.se/bib/2781394.
MKoma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels. A controlled prospective study. XVII Biennial Congress of the International Society of University Colon and Rectum Surgeons (ISUCRS), Malmo, Sweden. 1998; ((June 7-11)): PC173.
M'Koma AE. Editor: Jeanette de Putter. The State of Affairs in Europe (AIDS Mobility). [place unknown: publisher unknown]; 1998. Available from: http://www.biblio.com/details.php?dcx=105972577&aid=frg.
M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on lipid metabolism. Eur Surg Res, XXXII Congress of the European Surgical Research (ESSR), Corfu, Greece. 1997; 29 suppl 1((May 18-21)): 3.
M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels. A controlled prospective study. Eur Surg Res, XXXII Congress of the European Surgical Research (ESSR), Corfu, Greece. 1997; 29 suppl 1((May 18-21)): 4.
MKoma AE, Lindgren S.. Migration and Health (1996). Gender and HIV/AIDS awareness in the African population of Sweden [monograph]. First. Umea (Sweden): Umea University Hospital, Department of family medicine and Karolinska Nobel Institute, Huddinge University Hospital, Department of Clinical Science, Division of Obstetrics and Gynecology; 1996.Available from: http://www.umu.se/.
M'Koma AE, Lindquist K, Liljeqvist L.. Adaptive returns to normal serum electrolytes after depletion following restorative proctocolectomy and ileal-pouch anal anstomosis. A controlled, prospective study. Int J Surg Sci. 1995; ((2)): 330-4.
M'Koma AE. Institutional unawareness of immigrants competence. Swedish Daily News. 1995; ((January 21)): B16.
M'Koma AE. Follow-up results of hematology data before and after restorative proctocolectomy. Clinical outcome. Dis. Colon Rectum. 1994 Sep; 37(9): 932-7. PMID: 8076494, ISSN: 0012-3706.
M'Koma AE, Lindquist K, Liljeqvist L. Biochemical laboratory data in patients before and after restorative proctocolectomy. A study on 83 patients with a follow-up of 36 months. Ann Chir. 1994; 48(6): 525-34. PMID: 7847701, ISSN: 0003-3944.
M'Koma AE. Screening Africans in the EU borders does not prevent HIV-spread. Solution is to increase information. Swedish Daily News. 1993; ((June, 6)): A07.
M'Koma AE, Lindquist K, Liljeqvist L. Biohemical Laboratory Data in patients Undergoing Ileoanal Pouch Surgery. Annales de Chirurgie. 1992; Ileal pouch-anal anastomosis, International Symposium. Versailles, France((September 18-19)): 15:26. PMID: 7847701.
Rana T, Olga OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Nian N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Correction: Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 19(5): e0304732. PMID: 38809824.
M'Koma AE, Johnson SM, et al. Colorectal Inflammatory Bowel Disease in Sub-Saharan Africa: Diagnostic Challenges and Systemic Care Constraints. Am Surg. In Press.
M'Koma AE, Johnson SM. Colorectal Inflammatory Bowel Disease in Sub-Saharan Africa: Diagnostic Challenges and Systemic Care Constraints. Am Surg. 2026 Aug 8/17/2026; 31348261471491. PMID: 42608668, DOI: 10.1177/00031348261471491, ISSN: 1555-9823.
M'Koma AE, et al. Correction: Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis. J Clin Med. 2026 Feb 2/14/2026; 15(4): 1519. Communication: Special Issue. PMID: 41375691.
M'Koma AE. Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis. J Clin Med. c2025 Nov 11/26/2025; (14): 8390. Communication , Special Issue. PMID: 41375691.
Thangaiya T, Shanker A, Ballard BR, M'Koma AE. Structural and Epitope Characterization of Anti-DEFA5 Monoclonal Antibodies for Diagnostics in Inflammatory Bowel Disease. Int J Biol Macromol. c2025 Oct 10/7/2025; 330: 148024. PMID: 41067337.
M'Koma AE. Methods for diagnosing and treating inflammatory bowel disease (IBD). Nashville, Tennessee (United States): The United States Patent and Trademark Office (USPTO); c2025 Feb 2/4/2025.The patent details further methodology for the diagnosis and treatment of IBD. It is an extension of research to identifying molecular differentiation of IBD subtypes.
Thangaiyan R, Sakwe AM, Hawkins AT, Washington MK, Ballard BR, Izban MG, Chirwa SS, Hildreth JEK, Shanker A, Blum DL, M'Koma AE. Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues. Inflamm Res. 2025 Jan 1/30/2025; 74(1): 30. PMID: 39883179.
Featured on the Cover Story of the World Journal Gastrointestinal Endoscopy, 2025. World Journal of Gastrointestinal Endoscopy. 2025 Jan 1/16/2025; 17(1) Sect. Latest Archive, 2025:100472 (col. Journal WJGE).
M'Koma AE, Sakwe AM. Targeted HD5 antibody and assay methods for diagnosing and treating inflammatory bowel disease. Washongton DC (United States): United States Patent and Trademark Office (USPTO); 2024 Dec 12/24/2024.PII: 12174200.
Thangaiyan R, Sakwe AM, Hawkins AT, Washington MK, Ballard BR, Izban MG, Chirwa SS, Hildreth JEK, Shanker A, Blum DL, M'Koma AE. Anti-DEFA5 Monoclonal Antibody Clones 1A8 and 4F5 Immunoreactive Bioassay for Diagnosing Inflammatory Bowel Disease. Inflamm Res. 2024 Aug 8/29/2024; 1-25. PMID: 39257990.
Hajri TH, Gharib MG, Fungwe FT, M'Koma AE. Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance. Am J Physiol Heart Circ Physiol. 2024 May 5/24/2024; PMID: 38787383.
Breaux WA, Bragg MA, M'Koma AE. Ubiquitous Colonic Ileal Metaplasia Consistent with the Diagnosis of Crohn's Colitis among Indeterminate Colitis Cohorts. Med Res Arch. 2023 Aug 8/1/2023; 11(8): 4188. PMID: 37854669.
Johnson JC, Geesala R, Zhang K, Lin YM, M'Koma AE, Shi XZ. Smooth muscle dysfunction in the pre-inflammation site in stenotic Crohn's-like colitis: implication of mechanical stress in bowel dysfunction in gut inflammation. Front Physiol. 2023 Jul 7/14/2023; 14(14): 1215900. PMID: 37520831.
Bragg MA, Breaux WA, M'Koma AE. Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational and Transformational Risks Posed by Exogenous Free Hemoglobin Alpha Chain, A By-Product of Extravasated Erythrocyte Macrophage Erythrophagocytosis. Medicina (Kaunas). 2023 Jul 7/1/2023; 59(7): 1-19. PMID: 37476546.
M'Koma AE, Ware JN, Nabaweesi RK, Chirwa SS. Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood. Med Res Arch. 2023 Jun 6/1/2023; 6(11): 3784.
M'Koma AE. Inflammatory Bowel Disease: Clinical Diagnosis and Pharmaceutical Management. Med Res Arch. c2023 Jan 1/31/2023; 11(1): PMID: 37089816.
M'Koma AE. Amosy M'Koma Featured on the Cover Story of World Journal of Gastrointestinal Endoscopy. World J Gastrointest Endosc (WJGE). c2023 Jan 1/16/2023; 15(1): 1. PII: 1948-5190, PII: doi: 10.4253/wjge.v15.i1.10, ISSN: ISSN 1948-5190 (online).
Featured on the Cover Story of World Journal of Gastrointestinal Endoscopy. 2023. WJGE (World Journals-Baishideng). 2023 Jan 1/1/2023.
M'Koma AE. Methods for Diagnosing and Treating Inflammatory Bowel Disease. Nashville (United States): United States Patent and Trademark Office (USPTO); 2022 Aug 8/30/2022.PII: 11427852. *Publication of US11427852B2 *Granted on 2022-08-30 *Status - Active *Adjusted expiration date - 2038-04-14.
M'Koma AE. Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview. Medicina. 2022 Apr 4/21/2022; 58(5): 567-80. PMID: 35629984.
Geesala R, Lin YM, Zhang K, M'Koma AE, Cohn S, Shi XZ. Novel Insights into the mechanism of action of exclusive enteral nutrition in Crohn's disease: Pre-clinical study in a rodent model of Crohn's-like colitis. Inflammatory Bowel Disease (IBD). c2022 Jan 1/22/2022; 28(Supplemental 1): S27-S28.
M'Koma AE, Sakwe AM. Targeted HD5 Antibody and Assay Methods for Diagnosing and Treating Inflammatory Bowel Disease. Nashville (United States): US Patent App. 16/622,269; 2021 Sep 9/9/2021.ISSN: WO2018237064A1, ISSN: United States Patent Application 20210278417.
Lin You-Min, Qiu Suimmin, M'Koma Amosy E, Powell Don W, Cohn Steven, Shi Xuan-Zheng P. Sa130 mechanical stress plays a critical role in intestinal fibrosis and smooth muscle hyperplasia in a rodent model of Crohn's disease. Gastroenterology. 2021 May 5/1/2021; 160(6): S-431.
M'Koma AE. The diagnostic potential of human alpha defensin 5 in inflammatory bowel disease. Dis Colon Rectum. c2021 May 5/1/2021; 64(5).
Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Hui N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 2021 Mar; 16(3): e0246393. PMID: 33690604, PMCID: PMC7942995, PII: PONE-D-20-32369, DOI: 10.1371/journal.pone.0246393, ISSN: 1932-6203.
Herman AM, Hawkins AT, James SD, Ballard BR, M'Koma AE. Inflammatory Bowel Disease On-Line Web-Based Guide to Health Professionals and Patients in Developing and African Nations. JJGH. 2020 Mar 3/24/2020; 3(2): 1-11.
James SD, Hawkins AT, Um JW, Ballard BR, Smoot DT, M'Koma AE. The MYTHS of De novo Crohn's Disease After Restorative Proctocolectomy with Ileal Pouch-anal Anastomosis for Ulcerative Colitis. JJGH. 2020 Mar 3/11/2020; 3(2): 1-10.
Ballard BR, M'Koma AE. Paneth Cell Physiology and Pathophysiology in Inflammatory Bowel Disease. Digestive System Diseases. Stem Cell Biology and Regenerative Medicine. 1. Switzerland: Springer; 2019 Mar.180 p. ISBN-13: 978-3-030-11965-2.. Available from: https://link.springer.com/chapter/10.1007/978-3-030-11965-2_9.
M'Koma AE. The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview. Gastrointest Disord. 2018 Oct 10/18/2018; 1(1): 75-105. DOI: https://doi.org/10.3390/gidisord1010007.
James SD, Hawkins AT, M'Koma AE. Adenocarcinoma at the Ileostomy Site After a Proctocolectomy for Ulcerative Colitis and/or Familial Adenomatous Polyposis: An Overview. Ostomy Wound Manage. 2018 Jul 7/31/2018; 64(6): 30-40. PMID: 30059346.
Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Clin Med Insights Gastroenetrol. 2017 Dec 12/13/2017; 10: 1-6. PMID: 29276421.
Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017 Dec 12/6/2017; PMID: 29211779.
M'Koma AE. Editorial Policies and Skills to Solving Diagnostic Delay in Inflammatory Bowel Disease. Gen Surg Rep. 2017 Sep 9/22/2017; 1(1): 1-2.
Williams AD, korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human Alpha Defensin-5 is a Candidate Biomarker to Delineate Inflammatory Bowel Disease. PLoS One. 2017 Aug 8/17/2017; 12(8): e0179710. PMID: 28817680.
Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Clin Med Insights Gastroenterol. 2017; 10: 1179552217746692. PMID: 29276421, PMCID: PMC5734426, PII: 10.1177_1179552217746692, DOI: 10.1177/1179552217746692, ISSN: 1179-5522.
World Journal of Surgical Procedures. Amosy M'Koma Featured on the Cover Story of World Journal of Surgical Procedures. Pleasanton (United States): Baishideng Publishing Group Inc.; 2015 Mar 3/28/2015.1-176 p. ISSN: 2219-2832.
M'Koma AE. Diagnosis of Inflammatory Bowel Disease: Potential Role of Molecular Biometrics. In: World Clinical Inflammatory Bowel Disease. 1. Pleasanton (United States): Baishideng Publishing Group Inc; 2015 Feb 2/8/2015.E-Book Chapter 1-1215; p. 1204-15. ISBN-13: 978-0-9914430-5-5.
Vaiopoulou A, Gazouli M, Papadopoulou A, Anagnostopoulos AK, Karamanolis G, Theodoropoulos GE, M'Koma A, Tsangaris GT.. Serum Protein Profiling of Adults And Children With Crohn's Disease. J Peduiatr Gastroenterol Nutr. 2015; 60(1): 42-7. PMID: 25250685.
Korolkova OY, Myers JN, Pellom ST, Wang L, M'Koma AE. Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides. Clin Med Insights Gastroenterol. 2015; (8): 29-44. PMID: 26078592.
Ballard BR, M'Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis. World J Gastrointest Endosc. 2015; 7(7): 670-4. PMID: 26140094.
Myers JN, Schaffer MW, Korolkova OY, Williams AD, Gangula PR, M'Koma AE. Implications of the Colonic Deposition of Free Hemoglobin-a Chain: A Previously Unknown Tissue By-product in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2014; 20(9): 1530-47. PMID: 25078150.
M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg. 2014; 6(11): 208-119. PMID: 25429322.
Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013 Aug; 7(7-8): 541-9. PMID: 23382084, PMCID: PMC3737405, DOI: 10.1002/prca.201200107, ISSN: 1862-8354.
Smith JC, Schaeffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas after Prophylactic Surgery for Familial Adenomatous Polyposis. J Cancer Ther. 2013; 4(1): 260-70. PMID: 23875116.
M'Koma AE. Inflammatory Bowel Disease: An Expanding Global Health Problem. Clin Med Insights Gastroenterol. 2013; 6: 33-47. PMID: 24833941.
M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment After Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2): PMID: 24817992.
M'Koma AE. Letter to the Editor, Advances in Enzyme Research. Adv Enzyme Res. 2013; 1(4): 77-8. PMID: 25664328.
M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2): PMID: 24817992, PMCID: PMC4012278, ISSN: 1941-8213.
Um JW, M'Koma AE. Dysplasie und Adenokarzinome im Ileum-Pouch nach restaurativer Proktokolektomie wegen Colitis ulcerosa. Coloproctocology. 2011; 33: 273-82. ISSN: 1615-6730, ISSN: 0174-2442.
M'Koma AE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Wise PE, Caplioli RM.. Proteomic Profiling of Mucosal and Submucosal Colonic Tissues Yields Protein Signatures that Differentiate the Inflammatory Colitides. Inflamm Bowel Dis. 2011; 17((4)): 875-83. PMID: 20806340.
Um JW, M'Koma AE. Pouch-related dysplasia and adenocarcinoma following restorative proctocolectomy for ulcerative colitis. Tech Coloproctol. 2011; 15((1)): 7-16. PMID: 21287223.
M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2011; 26((5)): 533-52. PMID: 21311893.
Amosy M'Koma. Biochemical Laboratory Data Following Restorative Proctocolectomy:Observations on Essential Biochemical Data Profile in Connection with Restorative Proctocolectomy in Humans. First. Berlin (Germany): Lambert Academic Publishing AG & Co.; 2010 Apr 4/10/2010.74 p. ISBN-13: 978-3-8383-2057-1, ISBN-13: ISBN-10: 3838320573.. Available from: https://www.amazon.com/Biochemical-Laboratory-Following-Restorative-Proctocolectomy/dp/3838320573.
M'Koma AE, Wise PE, Schwartz DA, Muldoon RL, Herline AJ.. Prevalence and Outcome of Anemia after Restorative Proctocolectomy. Clinical Literature Review. Dis Colon Rectum. 2009; 52((4)): 726-36. PMID: 19404082.
Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith Jr JA, Clark PE, Bhowmick NE. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res. 2008; 14((23)): 7790-7. PMID: 19047106.
M'Koma AE, Wise PE, Muldoon RL, Schwartz DA, Washington MK, Herline AJ. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. Int J Colorectal Dis. 2007 Oct; 22(10): 1143-63. PMID: 17576578, DOI: 10.1007/s00384-007-0331-x, ISSN: 0179-1958.
M'Koma AE, Longo WE. Postoperative liver enzyme abnormalities are related to staged restorative proctocolectomy. Int J Colorectal Dis. 2007 Mar; 22(3): 283-8. PMID: 16583192, DOI: 10.1007/s00384-006-0130-9, ISSN: 0179-1958.
M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem. Biophys. Res. Commun. 2007 Feb 2/16/2007; 353(3): 829-34. PMID: 17194448, PMCID: PMC2562600, PII: S0006-291X(06)02787-2, DOI: 10.1016/j.bbrc.2006.12.111, ISSN: 0006-291X.
M'Koma AE. Serum biochemical evaluation of patients with functional pouches ten to 20 years after restorative proctocolectomy. Int J Colorectal Dis. 2006 Oct; 21(7): 711-20. PMID: 16437210, DOI: 10.1007/s00384-005-0076-3, ISSN: 0179-1958.
M'Koma AE, et al. Advances and challenges in the diagnostic accuracy for surgical management of inflammatory bowel disease: Potential role of molecular biometrics. J Clin Cell Immunol. c2004 Sep 9/29/2004.
Swedish Government. Swedish Ministry of Heath. First. Stockholm (Sweden): Fritzes Offentliga Publikationer (SU 2004); 2004.240 p. ISBN-13: 91-38-22080-6.. Available from: http://www.regeringen.se/sb/d/189/a/3004.
M'Koma AE. Observations On Essential Biochemical Data Profile In Connection With Restorative Proctocolectomy In Humans: Vitamin B12 and Fat Absorption Cited. First. Stockholm (Sweden): Karolinska Universiry Press; 2001 Nov 11/8/2001.126 p. ISBN-13: 91-7349-007-5.. Available from: https://openarchive.ki.se/articles/thesis/Observations_on_essential_biochemical_data_profile_in_connection_with_restorative_proctocolectomy_in_humans_vitamin_B12_and_fat_absorption_cited/26908285?file=48950818.
M'Koma AE, Lindquist K, Liljeqvist L. Observations in the blood lipid profile in patients undergoing restorative proctocolectomy. Int. J. Surg. Investig. 2000; 2(3): 227-35. PMID: 12678523, ISSN: 1028-5229.
M'Koma AE, Lindquist K, Liljeqvist L. A study of plasma immunoglobulins profile in connection with restorative proctocolectomy. Int. J. Surg. Investig. 2000; 2(2): 125-31. PMID: 12678510, ISSN: 1028-5229.
M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels: a prospective study. Dis. Colon Rectum. 1999 Mar; 42(3): 398-402. PMID: 10223764, ISSN: 0012-3706.
M'Koma AE. Observations on biochemical data in connection with restorative proctocolectomy: an analysis with specific reference to lipoproteins and gastric acids. First. Stockholm (Sweden): Karolinsks University Press; 1999.74 p. ISBN-13: 91-7349-0091.. Available from: http://libris.kb.se/bib/2781394.
MKoma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels. A controlled prospective study. XVII Biennial Congress of the International Society of University Colon and Rectum Surgeons (ISUCRS), Malmo, Sweden. 1998; ((June 7-11)): PC173.
M'Koma AE. Editor: Jeanette de Putter. The State of Affairs in Europe (AIDS Mobility). [place unknown: publisher unknown]; 1998. Available from: http://www.biblio.com/details.php?dcx=105972577&aid=frg.
M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on lipid metabolism. Eur Surg Res, XXXII Congress of the European Surgical Research (ESSR), Corfu, Greece. 1997; 29 suppl 1((May 18-21)): 3.
M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels. A controlled prospective study. Eur Surg Res, XXXII Congress of the European Surgical Research (ESSR), Corfu, Greece. 1997; 29 suppl 1((May 18-21)): 4.
MKoma AE, Lindgren S.. Migration and Health (1996). Gender and HIV/AIDS awareness in the African population of Sweden [monograph]. First. Umea (Sweden): Umea University Hospital, Department of family medicine and Karolinska Nobel Institute, Huddinge University Hospital, Department of Clinical Science, Division of Obstetrics and Gynecology; 1996.Available from: http://www.umu.se/.
M'Koma AE, Lindquist K, Liljeqvist L.. Adaptive returns to normal serum electrolytes after depletion following restorative proctocolectomy and ileal-pouch anal anstomosis. A controlled, prospective study. Int J Surg Sci. 1995; ((2)): 330-4.
M'Koma AE. Institutional unawareness of immigrants competence. Swedish Daily News. 1995; ((January 21)): B16.
M'Koma AE. Follow-up results of hematology data before and after restorative proctocolectomy. Clinical outcome. Dis. Colon Rectum. 1994 Sep; 37(9): 932-7. PMID: 8076494, ISSN: 0012-3706.
M'Koma AE, Lindquist K, Liljeqvist L. Biochemical laboratory data in patients before and after restorative proctocolectomy. A study on 83 patients with a follow-up of 36 months. Ann Chir. 1994; 48(6): 525-34. PMID: 7847701, ISSN: 0003-3944.
M'Koma AE. Screening Africans in the EU borders does not prevent HIV-spread. Solution is to increase information. Swedish Daily News. 1993; ((June, 6)): A07.
M'Koma AE, Lindquist K, Liljeqvist L. Biohemical Laboratory Data in patients Undergoing Ileoanal Pouch Surgery. Annales de Chirurgie. 1992; Ileal pouch-anal anastomosis, International Symposium. Versailles, France((September 18-19)): 15:26. PMID: 7847701.
Rana T, Olga OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Nian N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Correction: Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 19(5): e0304732. PMID: 38809824.
M'Koma AE, Johnson SM, et al. Colorectal Inflammatory Bowel Disease in Sub-Saharan Africa: Diagnostic Challenges and Systemic Care Constraints. Am Surg. In Press.